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Cédric Delevoye
Centre national de la recherche scientifique
39Publications
15H-index
1,101Citations
Publications 39
Newest
Published on Aug 1, 2019in Current Opinion in Cell Biology 8.23
Cédric Delevoye15
Estimated H-index: 15
(CNRS: Centre national de la recherche scientifique),
Michael S. Marks51
Estimated H-index: 51
(UPenn: University of Pennsylvania),
Graça Raposo92
Estimated H-index: 92
(CNRS: Centre national de la recherche scientifique)
Unique functions of specialised cells such as those of the immune and haemostasis systems, skin, blood vessels, lung, and bone require specialised compartments, collectively referred to as lysosome-related organelles (LROs), that share features of endosomes and lysosomes. LROs harbour unique morphological features and cell type-specific contents, and most if not all undergo regulated secretion for diverse functions. Ongoing research, largely driven by analyses of inherited diseases and their mod...
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Published on Jun 10, 2019in bioRxiv
Lia Domingues (PSL Research University), Ilse Hurbain1
Estimated H-index: 1
(PSL Research University)
+ 10 AuthorsKatell Vié3
Estimated H-index: 3
Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete specific factors transduced by melanocytes into signaling cues to promote their pigmentation and dendrite outgrowth, while melanocytes transfer melanin pigments to keratinocytes to convey skin photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we found that caveolae polarize in melanocyte...
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Published on Mar 15, 2019in PLOS Genetics 5.22
Justin Findinier1
Estimated H-index: 1
(University of Paris),
Cédric Delevoye15
Estimated H-index: 15
(CNRS: Centre national de la recherche scientifique),
Mickael M. Cohen5
Estimated H-index: 5
(University of Paris)
Large GTPases of the Dynamin Related Proteins (DRP) family shape lipid bilayers through membrane fission or fusion processes. Despite the highly organized photosynthetic membranes of thylakoids, a single DRP is known to be targeted inside the chloroplast. Fzl from the land plant Arabidopsis thaliana is inserted in the inner envelope and thylakoid membranes to regulate their morphology. Fzl may promote the fusion of thylakoids but this remains to be proven. Moreover, the physiological requirement...
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Published on Dec 1, 2018in EMBO Reports 8.38
Saurabh Shakya1
Estimated H-index: 1
(IISc: Indian Institute of Science),
Prerna Sharma8
Estimated H-index: 8
(IISc: Indian Institute of Science)
+ 3 AuthorsSubba Rao Gangi Setty4
Estimated H-index: 4
(IISc: Indian Institute of Science)
Abstract Recycling endosomes (REs) are transient endosomal tubular intermediates of early/sorting endosomes (E/SEs) that function in cargo recycling to the cell surface and deliver the cell type‐specific cargo to lysosome‐related organelles such as melanosomes in melanocytes. However, the mechanism of RE biogenesis is largely unknown. In this study, by using an endosomal Rab‐specific RNAi screen, we identified Rab22A as a critical player during RE biogenesis. Rab22A‐knockdown results in reduced ...
2 Citations Source Cite
Published on Sep 15, 2018in Journal of Cell Science 4.52
Sudeshna Nag1
Estimated H-index: 1
(IISc: Indian Institute of Science),
Shikha Rani1
Estimated H-index: 1
(IISc: Indian Institute of Science)
+ 9 AuthorsGuillaume van Niel22
Estimated H-index: 22
(PSL Research University)
Sorting endosomes (SEs) are the regulatory hubs for sorting cargo to multiple organelles, including lysosome-related organelles such as melanosomes in melanocytes. In parallel, melanosome biogenesis is initiated from SEs with the processing and sequential transport of melanocyte-specific proteins toward maturing melanosomes. However, the mechanism of cargo segregation on SEs is largely unknown. RNAi screening in melanocytes revealed that knockdown of Rab4A results in defective melanosome maturat...
1 Citations Source Cite
Published on Aug 6, 2018in Journal of Cell Biology 8.89
Léa Ripoll2
Estimated H-index: 2
(CNRS: Centre national de la recherche scientifique),
Léa Ripoll1
Estimated H-index: 1
(CNRS: Centre national de la recherche scientifique)
+ 8 AuthorsAnne Houdusse39
Estimated H-index: 39
(CNRS: Centre national de la recherche scientifique)
Vesicular and tubular transport intermediates regulate organellar cargo dynamics. Transport carrier release involves local and profound membrane remodeling before fission. Pinching the neck of a budding tubule or vesicle requires mechanical forces, likely exerted by the action of molecular motors on the cytoskeleton. Here, we show that myosin VI, together with branched actin filaments, constricts the membrane of tubular carriers that are then released from melanosomes, the pigment containing lys...
8 Citations Source Cite
Published on Feb 14, 2018in International Journal of Molecular Sciences 4.18
Cécile Campagne1
Estimated H-index: 1
,
Léa Ripoll2
Estimated H-index: 2
+ 2 AuthorsCédric Delevoye15
Estimated H-index: 15
Melanocytes are specialized cells that generate unique organelles called melanosomes in which melanin is synthesized and stored. Melanosome biogenesis and melanocyte pigmentation require the transport and delivery of melanin synthesizing enzymes, such as tyrosinase and related proteins (e.g., TYRP1), from endosomes to maturing melanosomes. Among the proteins controlling endosome-melanosome transport, AP-1 together with KIF13A coordinates the endosomal sorting and trafficking of TYRP1 to melanoso...
1 Citations Source Cite
Published on Dec 1, 2017in Journal of Cell Science 4.52
Ana Ramos-Nascimento2
Estimated H-index: 2
(MHH: Hannover Medical School),
Bárbara Kellen2
Estimated H-index: 2
+ 5 AuthorsMaria Joao Amorim13
Estimated H-index: 13
(IGC: Instituto Gulbenkian de Ciência)
Influenza A is a rapid evolving virus, successful in provoking periodic epidemics and occasional pandemics in humans. Viral assembly is complex as the virus incorporates an eight-partite segmented genome of RNA (in the form of viral ribonucleoproteins, vRNPs). Genome assembly, with implications to public health, is not completely understood. It was reported that vRNPs are transported to the cell surface on Rab11 vesicles using microtubules, but no molecular motor has been assigned to the process...
6 Citations Source Cite
Published on Jun 13, 2017in Nature Communications 11.88
Anand Patwardhan20
Estimated H-index: 20
,
Sabine Bardin12
Estimated H-index: 12
+ 4 AuthorsCédric Delevoye15
Estimated H-index: 15
The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.
10 Citations Source Cite
Published on Sep 1, 2016in Pigment Cell & Melanoma Research 4.17
Anand Patwardhan1
Estimated H-index: 1
(PSL Research University),
Cédric Delevoye15
Estimated H-index: 15
(PSL Research University)
3 Citations Source Cite
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