Cédric Delevoye
Centre national de la recherche scientifique
Publications 37
#1Cédric Delevoye (CNRS: Centre national de la recherche scientifique)H-Index: 17
#2Michael S. Marks (UPenn: University of Pennsylvania)H-Index: 52
Last.Graça Raposo (CNRS: Centre national de la recherche scientifique)H-Index: 95
view all 3 authors...
Unique functions of specialised cells such as those of the immune and haemostasis systems, skin, blood vessels, lung, and bone require specialised compartments, collectively referred to as lysosome-related organelles (LROs), that share features of endosomes and lysosomes. LROs harbour unique morphological features and cell type-specific contents, and most if not all undergo regulated secretion for diverse functions. Ongoing research, largely driven by analyses of inherited diseases and their mod...
3 CitationsSource
#1Lia Domingues (PSL Research University)H-Index: 4
#2Ilse Hurbain (PSL Research University)H-Index: 20
Last.Cédric Delevoye (PSL Research University)H-Index: 17
view all 13 authors...
Tissue homeostasis requires regulation of cell-cell communication, which relies on signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete specific factors transduced by melanocytes into signaling cues to promote their pigmentation and dendrite outgrowth, while melanocytes transfer melanin pigments to keratinocytes to convey skin photoprotection. How epidermal cells integrate these functions remains poorly characterized. Here, we found that caveolae polarize in melanocyte...
1 CitationsSource
#1Justin Findinier (University of Paris)H-Index: 2
#2Cédric Delevoye (CNRS: Centre national de la recherche scientifique)H-Index: 17
Last.Mickael M. Cohen (University of Paris)H-Index: 6
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Large GTPases of the Dynamin Related Proteins (DRP) family shape lipid bilayers through membrane fission or fusion processes. Despite the highly organized photosynthetic membranes of thylakoids, a single DRP is known to be targeted inside the chloroplast. Fzl from the land plant Arabidopsis thaliana is inserted in the inner envelope and thylakoid membranes to regulate their morphology. Fzl may promote the fusion of thylakoids but this remains to be proven. Moreover, the physiological requirement...
3 CitationsSource
#1Saurabh Shakya (IISc: Indian Institute of Science)H-Index: 1
#2Prerna Sharma (IISc: Indian Institute of Science)H-Index: 9
Last.Subba Rao Gangi Setty (IISc: Indian Institute of Science)H-Index: 4
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Abstract Recycling endosomes (REs) are transient endosomal tubular intermediates of early/sorting endosomes (E/SEs) that function in cargo recycling to the cell surface and deliver the cell type‐specific cargo to lysosome‐related organelles such as melanosomes in melanocytes. However, the mechanism of RE biogenesis is largely unknown. In this study, by using an endosomal Rab‐specific RNAi screen, we identified Rab22A as a critical player during RE biogenesis. Rab22A‐knockdown results in reduced ...
4 CitationsSource
#1Sudeshna Nag (IISc: Indian Institute of Science)H-Index: 1
#2Shikha Rani (IISc: Indian Institute of Science)H-Index: 1
Last.Subba Rao Gangi Setty (IISc: Indian Institute of Science)H-Index: 4
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Sorting endosomes (SEs) are the regulatory hubs for sorting cargo to multiple organelles, including lysosome-related organelles such as melanosomes in melanocytes. In parallel, melanosome biogenesis is initiated from SEs with the processing and sequential transport of melanocyte-specific proteins toward maturing melanosomes. However, the mechanism of cargo segregation on SEs is largely unknown. RNAi screening in melanocytes revealed that knockdown of Rab4A results in defective melanosome maturat...
1 CitationsSource
#1Léa Ripoll (CNRS: Centre national de la recherche scientifique)H-Index: 2
#2Xavier Heiligenstein (CNRS: Centre national de la recherche scientifique)H-Index: 5
Last.Cédric Delevoye (CNRS: Centre national de la recherche scientifique)H-Index: 17
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Vesicular and tubular transport intermediates regulate organellar cargo dynamics. Transport carrier release involves local and profound membrane remodeling before fission. Pinching the neck of a budding tubule or vesicle requires mechanical forces, likely exerted by the action of molecular motors on the cytoskeleton. Here, we show that myosin VI, together with branched actin filaments, constricts the membrane of tubular carriers that are then released from melanosomes, the pigment containing lys...
10 CitationsSource
Melanocytes are specialized cells that generate unique organelles called melanosomes in which melanin is synthesized and stored. Melanosome biogenesis and melanocyte pigmentation require the transport and delivery of melanin synthesizing enzymes, such as tyrosinase and related proteins (e.g., TYRP1), from endosomes to maturing melanosomes. Among the proteins controlling endosome-melanosome transport, AP-1 together with KIF13A coordinates the endosomal sorting and trafficking of TYRP1 to melanoso...
1 CitationsSource
#1Ana Ramos-Nascimento (MHH: Hannover Medical School)H-Index: 2
#2Bárbara KellenH-Index: 2
Last.Maria Joao Amorim (IGC: Instituto Gulbenkian de Ciência)H-Index: 13
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ABSTRACT Influenza A is a rapidly evolving virus that is successful in provoking periodic epidemics and occasional pandemics in humans. Viral assembly is complex as the virus incorporates an eight-partite genome of RNA (in the form of viral ribonucleoproteins, vRNPs), and viral genome assembly − with its implications to public health − is not completely understood. It has previously been reported that vRNPs are transported to the cell surface on Rab11-containing vesicles by using microtubules bu...
7 CitationsSource
#1Anand Patwardhan (PSL Research University)H-Index: 3
#2Sabine Bardin (PSL Research University)H-Index: 13
Last.Cédric Delevoye (PSL Research University)H-Index: 17
view all 7 authors...
The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.
17 CitationsSource