Jelena Filipović-Grčić
University of Zagreb
LiposomeChemistryChitosanChromatographyDosage form
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Publications 101
#1Monika BarbarićH-Index: 9
#2Anita MartinacH-Index: 7
Last. Branka ZorcH-Index: 19
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#1Anita MartinacH-Index: 7
Last. Ivan JalšenjakH-Index: 20
view all 3 authors...
#1Bisera Jurišić Dukovski (University of Zagreb)H-Index: 3
#2Marina Juretić (Pliva (Croatia))H-Index: 3
Last. Jasmina Lovrić (University of Zagreb)H-Index: 13
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Abstract Inflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation issues. The aim of this study was development and optimization of functional cationic nanoemulsions (NEs) for DED treatment, as a formulation approach to circumvent solubility problems, prolong drug residence at the ocular sur...
3 CitationsSource
#1Marieta Duvnjak Romić (Pliva (Croatia))H-Index: 3
#2Anja Sušac (University of Zagreb)
Last. Anita Hafner (University of Zagreb)H-Index: 13
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The aim of this study was to evaluate long-term stability and assess the wound healing potential of the innovative melatonin-loaded lipid-enriched hybrid system compared to conventional melatonin-loaded chitosan microspheres. The hybrid system contained nanostructured lipid carrier incorporated in the chitosan matrix, in order to modify melatonin release and alter physicochemical characteristics of the delivery system. Stability testing was performed during a six-month period under two condition...
#1Marieta Duvnjak Romić (Pliva (Croatia))H-Index: 3
#2Drago Špoljarić (Pliva (Croatia))H-Index: 2
Last. Anita Hafner (University of Zagreb)H-Index: 13
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Abstract The aim of this study was to develop nanostructured lipid carrier (NLC)-loaded chitosan-based microspheres as innovative dry powder wound dressing, with melatonin incorporated in both, NLC and chitosan matrix of the proposed hybrid system. Melatonin-loaded NLCs were prepared by a hot homogenization technique, while NLC-loaded microspheres were produced by a spray-drying method. To optimize the critical formulation and process parameters for both NLC and hybrid system, a definitive scree...
2 CitationsSource
#1Željka Vanić (University of Zagreb)H-Index: 10
#1Zeljka Vanic (University of Zagreb)H-Index: 4
Last. Nataša Škalko-BasnetH-Index: 26
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Background: Efficient localized cervicovaginal antibacterial therapy, enabling the delivery of antibiotic to the site of action at lower doses while escaping systemic drug effects and reducing the risk of developing microbial resistance, is attracting considerable attention. Liposomes have been shown to allow sustained drug release into vaginal mucosa and improve delivery of antibiotics to bacterial cells and biofilms. Azithromycin (AZI), a potent broad-spectrum macrolide antibiotic, has not yet...
3 CitationsSource
#1Ivona Tomić (University of Mostar)H-Index: 1
#2Marina Juretić (Pliva (Croatia))H-Index: 3
Last. Jelena Filipović-Grčić (University of Zagreb)H-Index: 24
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Abstract Azelaic acid (AZA) is a dicarboxylic acid that is topically used in the treatment of acne and rosacea since it possesses antibacterial and keratolytic activity. The primary objective of this study was to develop an AZA nanocrystal suspension. It is expected that improved solubility and dissolution rate will result in advanced biopharmaceutical properties, primarily the dermal bioavailability. Furthermore, a topical nanocrystal AZA-loaded hydrogels composed of Pluronic® F127 and hyaluron...
5 CitationsSource
#1Bisera Jurišić Dukovski (University of Zagreb)H-Index: 3
#2Lea Mrak (University of Zagreb)H-Index: 1
Last. Anita Hafner (University of Zagreb)H-Index: 13
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AbstractIn this study, we present the development of an innovative dry powder dexamethasone (Dex) nasal delivery system comprising Dex-loaded lipid/alginate nanoparticles incorporated within pectin...
4 CitationsSource
#1Zora Rukavina (University of Zagreb)H-Index: 3
#2Maja Šegvić Klarić (University of Zagreb)H-Index: 15
Last. Željka Vanić (University of Zagreb)H-Index: 10
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Abstract Antibiotic delivery via liposomal encapsulation represents a promising approach for the efficient topical treatment of skin infections. The present study aimed to investigate the potential of using different types of azithromycin (AZT)-loaded liposomes to locally treat skin infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains. Conventional liposomes (CLs), deformable liposomes (DLs), propylene glycol-containing liposomes (PGLs) and cationic liposomes (CATLs) e...
9 CitationsSource