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Lucinda J. Bessa
University of Porto
39Publications
11H-index
452Citations
Publications 39
Newest
Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide. This last step takes advantage of the electrophilic feature of the MBH residue and represents a new cyclization strategy occurring. The analogues were prepared in moderate overall yields and did not show toxic effects on Staphylococcus aureus growth and were...
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#1Ana Sofia Gomes (University of Porto)
#2Lucinda J. Bessa (University of Porto)H-Index: 11
Last.Paula Gomes (University of Porto)H-Index: 33
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Antimicrobial resistance is becoming one the most serious health threats worldwide, as it not only hampers effective treatment of infectious diseases using current antibiotics, but also dramatically increases the risks of medical procedures like surgery, transplantation, bone and dental implantation, chemotherapy, or chronic wound management. To date, there are no effective measures to tackle life-threatening nosocomial infections caused by multidrug resistant bacterial species, of which Gram-ne...
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#1Andreia Leite (University of Porto)H-Index: 11
#2Lucinda J. Bessa (University of Porto)H-Index: 11
Last.Maria RangelH-Index: 19
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Abstract In this work, we report the synthesis and characterization of three novel copper(II) complexes of naphthyl derived 3-hydroxy-4-pyridinone chelators. Their antibacterial activity against several Gram-positive and Gram-negative reference strains and multidrug-resistant clinical isolates was assessed through determination of the minimum inhibitory concentration (MIC). The complex Cu(naph1pp)2 shows the highest antibacterial activity, including against multidrug-resistant isolates, nonethel...
1 CitationsSource
Pseudomonas aeruginosa and Staphylococcus aureus are two major pathogens involved in a large variety of infections. Their co-occurrence in the same site of infection has been frequently reported and is linked to enhanced virulence and difficulty of treatment. Herein, the antimicrobial and antibiofilm activities of an intragenic antimicrobial peptide (IAP), named Hs02, which was uncovered from the human unconventional myosin 1H protein, were investigated against several P. aeruginosa and S. aureu...
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#1Lucinda J. Bessa (University of Porto)H-Index: 11
#2Mariana Ferreira (University of Porto)H-Index: 6
Last.Paula Gameiro (University of Porto)H-Index: 25
view all 3 authors...
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#1Lucinda J. Bessa (University of Porto)H-Index: 11
#2Mariana Ferreira (University of Porto)H-Index: 6
Last.Paula Gameiro (University of Porto)H-Index: 25
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Abstract The data presented are related to the research article entitled “Evaluation of membrane fluidity of multidrug-resistant isolates of Escherichia coli and Staphylococcus aureus in presence and absence of antibiotics” (Bessa et al., 2018) [1]. This data article provides a dataset that includes emission spectra of Laurdan-labeled bacteria, namely of three Escherichia coli and three Staphylococcus aureus strains. Laurdan (6-dodecanoyl-2-dimethylaminonaphthalene) is a popular fluorescence pro...
3 CitationsSource
#1Ana Barbosa-Vasconcelos (University of Porto)H-Index: 3
#2Ângelo Mendes (University of Porto)H-Index: 5
Last.Lucinda J. Bessa (University of Porto)H-Index: 11
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1 CitationsSource
#1Mariana Hinzmann (University of Porto)H-Index: 6
#2Lucinda J. Bessa (University of Porto)H-Index: 11
Last.Jorge Machado (University of Porto)H-Index: 22
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ABSTRACT The populations of freshwater mussels belonging to the family Unionidae have been facing drastic changes in terms of diversity and numbers caused by constant aggressions on their natural habitat. Nevertheless, bivalves are capable of developing strategies of defense to overcome potential aggressors. The present work aimed to assess the potential antibacterial capacity of different species of unionid mussels from the north of Portugal. For this purpose, circulating cells (hemocytes), flu...
1 CitationsSource
#1Lucinda J. Bessa (University of Porto)H-Index: 11
#2Mariana Ferreira (University of Porto)H-Index: 6
Last.Paula Gameiro (University of Porto)H-Index: 25
view all 3 authors...
Abstract In the face of the serious problem of antimicrobial resistance and the global dissemination of multidrug-resistant (MDR) bacteria, it is relevant to deeply study such bacteria both genetically and phenotypically. It is well known that bacteria have the ability to modify the biophysical properties of their cytoplasmic membranes, namely fluidity, in order to survive and thrive in hostile environments. The aim of this study was to assess and compare the membrane fluidity among multidrug-re...
10 CitationsSource
#1Lucinda J. Bessa (University of Porto)H-Index: 11
#2Peter Eaton (University of Porto)H-Index: 21
Last.Paula Gameiro (University of Porto)H-Index: 25
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7 CitationsSource
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