Sebastian Gidlöf
Karolinska Institutet
Publications 17
#1Martin Solders (KI: Karolinska Institutet)H-Index: 5
#2Laia Gorchs (KI: Karolinska Institutet)H-Index: 2
Last.Helen Kaipe (KI: Karolinska Institutet)H-Index: 6
view all 10 authors...
The intervillous space of the placenta is a part of the fetal-maternal interface, where maternal blood enters to provide nutrients and gas exchange. Little is known about the maternal immune cells at this site, which are in direct contact with fetal tissues. We have characterized the T cell composition and chemokine profile in paired intervillous and peripheral blood samples from healthy mothers giving birth following term pregnancies. Mucosal-associated invariant T (MAIT) cells and effector mem...
#1Dorina Ujvari (KI: Karolinska Institutet)H-Index: 6
#2Ivika Jakson (KI: Karolinska Institutet)H-Index: 1
Last.Angelica Lindén Hirschberg (KI: Karolinska Institutet)H-Index: 34
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Prokineticin 1 (PROK1), a hypoxia-regulated angiogenic factor, has emerged as a crucial regulator of embryo implantation and placentation. Dysregulation of PROK1 has been linked to recurrent pregna ...
#1Fawaz Abomaray (KI: Karolinska Institutet)H-Index: 6
#2Sebastian Gidlöf (KI: Karolinska Institutet)H-Index: 7
Last.Cecilia Götherström (KI: Karolinska Institutet)H-Index: 21
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Endometriosis is an inflammatory disease marked by ectopic growth of endometrial cells. Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases. Therefore, the aim herein was to examine effects of allogeneic MSC on endometriosis-derived cells in vitro as a potential therapy for endometriosis. MSC from allogeneic adipose tissue (Ad-MSC) and stromal cells from endometrium (ESCendo) and endometriotic ovarian cysts (ESCcyst)...
#1Martin Solders (Karolinska University Hospital)H-Index: 5
#2Laia Gorchs (Karolinska University Hospital)H-Index: 2
Last.Helen Kaipe (Karolinska University Hospital)H-Index: 6
view all 9 authors...
During pregnancy, the maternal immune system must tolerate the developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on the MR1 molecule, but their presence and function at the foetal-maternal interface is not known. We here isolated mononuclear cells from paired samples of peripheral blood (PB), intervillous blood (IVB), and decidua parietalis (DP) following...
#1Martin Solders (Karolinska University Hospital)H-Index: 5
#2Laia Gorchs (Karolinska University Hospital)H-Index: 2
Last.Helen Kaipe (Karolinska University Hospital)H-Index: 6
view all 6 authors...
The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly characterized in the two anatomically different decidual tissues, basalis and parietalis. We examined immune cells from decidua basalis and parietalis from term placentas () with f...