Match!
Makoto Shimizu
University of Tokyo
141Publications
31H-index
3,356Citations
Publications 139
Newest
#1Mika Sato (Tokyo University of Agriculture)
#2Akihiko Inaba (Tokyo University of Agriculture)
Last.Kazuo Kobayashi-Hattori (Tokyo University of Agriculture)H-Index: 13
view all 7 authors...
ABSTRACTReg3β, a lectin, displays antibacterial activity. This study investigated Reg3β-expressing cells using IL-22-stimulated enteroids. IL-22 stimulation elevated the mRNA and protein levels of ...
Source
#1Kousuke Harada (Tokyo University of Agriculture)
#2Yuria Kato (Tokyo University of Agriculture)
Last.Kazuo Kobayashi-Hattori (Tokyo University of Agriculture)H-Index: 13
view all 10 authors...
Adipose tissue is an endocrine organ and its endocrine function is closely associated with type 2 diabetes mellitus. Valeriana officinalis (Valerian) exerts some physiological effects; however, its influence on adipocytes remains unclear. We investigated the effect of methanolic Valerian root extract (Vale) on 3T3-L1 adipocytes. Vale (1, 10, and 100 μg/mL) dose-dependently promoted adipocyte differentiation with increasing lipid accumulation. In addition, Vale significantly increased the mRNA le...
Source
#1Miho Chikazawa (UTokyo: University of Tokyo)H-Index: 1
#2Makoto Shimizu (UTokyo: University of Tokyo)H-Index: 31
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 4 authors...
Abstract Muscle myogenesis is an essential step for muscle development and recovery. During muscle fusion, multiple molecules are thought to be necessary for the formation of normal myotubes. Milk fat globule-EGF factor 8 (MFG-E8) and Gas6 are phosphatidylserine-recognizing bridging molecules that are secreted mainly from immune cells. In this study, we confirmed that these molecules are expressed and secreted from C2C12 cells. Mouse muscle and satellite cells also expressed these molecules. MFG...
Source
#1Masamori Iwase (UTokyo: University of Tokyo)H-Index: 1
#2Kyoko Watanabe (Tokyo University of Agriculture)
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 7 authors...
ABSTRACTSterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthetic pathways. The present...
Source
#1Hideo Satsu (Maebashi Institute of Technology)H-Index: 24
#2Yusuke Gondo (UTokyo: University of Tokyo)H-Index: 2
Last.Makoto Shimizu (Tokyo University of Agriculture)H-Index: 27
view all 6 authors...
Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid, is a free amino acid present in high concentrations in mammalian tissues. Taurine has pivotal roles in anti-oxidation, membrane stabilization, osmoregulation, anti-inflammation, and other process. In a DNA microarray analysis, we previously found that taurine markedly increases the mRNA expression of thioredoxin interacting protein (TXNIP) in Caco-2 cells. In this study, we investigated the effect of these taurine-induced ch...
Source
#1Jun Inoue (UTokyo: University of Tokyo)H-Index: 3
#2Shingo Miyata (UTokyo: University of Tokyo)H-Index: 4
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 4 authors...
ABSTRACTSterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate a wide variety of genes involved in fatty acid and cholesterol synthesis. In the present study, we identified that isoxanthohumol (IXN) suppressed SREBP activity. Low concentrations of IXN (10 and 30 μM) reduced the amount of mature forms of SREBPs, while high concentration of IXN (100 μM) reduced both precursor and mature forms of SREBPs in Huh-7 cells. The IXN-mediated decrease in the precursor ...
3 CitationsSource
#1Ayane Kuboyama (UTokyo: University of Tokyo)H-Index: 2
#2Takashi Sasaki (UTokyo: University of Tokyo)H-Index: 34
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 5 authors...
AbstractTransmembrane protein 100 (TMEM100) comprises 134 amino acid residues and is highly conserved among vertebrates. Tmem100 has been recently reported as a key factor in angiogenesis, pain transmission, and tumor suppression. Although the importance of TMEM100 function is well supported, few studies have elucidated its expression mechanism. In the current study, we found that activating transcription factor 6α, a transcription factor activated by endoplasmic reticulum (ER) stress, enhanced ...
Source
#1Takashi SasakiH-Index: 34
#2Ayane KuboyamaH-Index: 2
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 8 authors...
3 CitationsSource
#1Miki MiyoshiH-Index: 7
#2Nobuo NishiH-Index: 18
Last.Makoto Shimizu (UTokyo: University of Tokyo)H-Index: 31
view all 6 authors...
Source
#1Ryuto Maruyama (UTokyo: University of Tokyo)H-Index: 4
#2Makoto Shimizu (UTokyo: University of Tokyo)H-Index: 31
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 6 authors...
3 CitationsSource
12345678910