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Sajjad Ahmad
Quaid-i-Azam University
35Publications
7H-index
128Citations
Publications 35
Newest
#1Rida Sajjad (QAU: Quaid-i-Azam University)
#2Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
Last.Syed Sikander Azam (QAU: Quaid-i-Azam University)H-Index: 13
view all 3 authors...
Abstract Globally, antibiotic-resistant and tolerated bacterial isolates of Acinetobacter species are imposing high financial cost on health care systems and as such, molecular targets with promising immune protection could provide substantive benefits to human healthcare. Here, we performed an in silico based proteome-wide screening for antigenic B-cell derived T-cell epitopes and their following use to design a multi-epitope peptide vaccine that can effectively engage the host immune system ag...
#1Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
#2Afifa Navid (QAU: Quaid-i-Azam University)H-Index: 1
Last.Horacio Pérez-Sánchez (Universidad Católica San Antonio de Murcia)H-Index: 17
view all 6 authors...
The emergence and dissemination of pan drug resistant clones of Klebsiella pneumoniae are great threat to public health. In this regard new therapeutic targets must be highlighted to pave the path for novel drug discovery and development. Subtractive proteomic pipeline brought forth UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC), a Zn+2 dependent cytoplasmic metalloprotein and catalyze the rate limiting deacetylation step of lipid A biosynthesis pathway. Primary sequence ana...
#1Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
#2Maimoona Gull (UoP: University of Peshawar)
Last.Muhammad Saleem Khan (Government College University)H-Index: 5
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In this study, different aerial parts of Monotheca Buxifolia were screened for their antibacterial, antifungal, and anti-oxidant activity . Extract of the fruit was most active against P. mirabilis, MSSA and M. morganii strains. Moreover, the methanolic fruit extract demonstrated good antibacterial properties against VRSA, S. aureus and Acinetobacter . Despite having good antibacterial properties, Monotheca buxifolia showed low antifungal activity. The cytotoxic activity was the highest in the p...
#1Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
#2Bilal Shaker (QAU: Quaid-i-Azam University)H-Index: 1
Last.Syed Sikander Azam (QAU: Quaid-i-Azam University)H-Index: 13
view all 5 authors...
AbstractAcinetobacter baumannii is an alarming nosocomial pathogen that is resistant to multiple drugs. The pathogen is forefront of scientific attention because of high mortality and morbidity found for its complications in the past decade. As a consequence, identification of novel drug candidates and subsequent designing of novel chemical scaffolds is an imperative need of time. In the present study, we used a recently reported structure of BfmR enzyme and performed structure based virtual scr...
#1Sohaila Andleeb (QAU: Quaid-i-Azam University)H-Index: 4
#2Imtiaz-ud-Din (QAU: Quaid-i-Azam University)H-Index: 11
Last.Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
view all 7 authors...
#1Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
#2Uzair Ali Murtaza (QAU: Quaid-i-Azam University)H-Index: 1
Last.Syed Sikander Azam (QAU: Quaid-i-Azam University)H-Index: 13
view all 4 authors...
Abstract Acinetobacter baumannii belongs to the most critical group of bacterial pathogens that are resistant to large number of antibiotics, including the highly effective carbapenems and third generation cephalosporins. Novel antibiotics targeting unique pathways of the said pathogen could reduce the mortality rate due to its infections that are impervious to the current antibiotics. Herein, we explored a library of natural compounds that was filtered first for drug-like, followed by lead-like...
#1Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
#2Kara E. Ranaghan (UoB: University of Bristol)H-Index: 15
Last.Syed Sikander Azam (QAU: Quaid-i-Azam University)H-Index: 3
view all 3 authors...
Abstract Global emergence of Tigecycline resistant Acinetobacter baumannii (TRAB) is on the horizon and poses a very serious threat to human health. There is a pressing demand for suitable therapeutics against this pathogen, particularly a vaccine to protect against TRAB infections. We present a comprehensive investigation of the complete proteome of a TRAB AB031 strain to predict promiscuous antigenic, non-allergenic, virulent B-cell derived T-cell epitopes and formulate a multi-epitope vaccine...
#1Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
#2Saad Raza (QAU: Quaid-i-Azam University)H-Index: 6
Last.Syed Sikander Azam (QAU: Quaid-i-Azam University)H-Index: 13
view all 5 authors...
KdsB (3-deoxy-manno-octulosonate cytidylyltransferase) is a highly specific and selective bacterial enzyme that catalyzes KDO (3-Deoxy-D-mano-oct-2-ulosonic acid) activation in KDO biosynthesis pat...
#1Qurat Ul Ain (QAU: Quaid-i-Azam University)H-Index: 4
#2Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
Last.Syed Sikander Azam (QAU: Quaid-i-Azam University)H-Index: 13
view all 3 authors...
Abstract Yersinia enterocolitica is the third most common cause of gastrointestinal manifestations in Europe. Statistically, every year the pathogen accounts for 640 hospitalizations, 117,000 illnesses, and 35 deaths in the United States. The associated mortality rate of the pathogen is 50% and is virtually resistant to penicillin G, ampicillin and cephalotin. The development of new and effective therapeutic procedures is urgently needed to counter the multi-drug-resistant phenotypes imposed by ...
#1Wasim Sajjad (QAU: Quaid-i-Azam University)H-Index: 1
#2Sajjad Ahmad (QAU: Quaid-i-Azam University)H-Index: 7
Last.Aamer Ali Shah (QAU: Quaid-i-Azam University)H-Index: 20
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Streptomyces genus are filamentous Gram positive bacteria, of great intrest, producing biologically active compounds. Recent market and consumer curiosity in natural products have forced scientist and industry for the development of new products with therapeutic potential. This study focuses on evaluation of antioxidant and anticancerous properties of prodigiosin from radio-resistant Streptomyces sp. strain WMA-LM31. A molecular docking approach was adopted to understand theoretical binding mech...
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