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Yanling Zhou
Guangzhou Medical University
28Publications
4H-index
81Citations
Publications 28
Newest
#1Weijian Liu (Guangzhou Medical University)H-Index: 2
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 0 authors...
Abstract Background Recent studies have suggested that neurocognition is changed after repeated infusions of ketamine in patients with treatment-resistant depression (TRD). The objective of this study was to investigate whether differences existed in the neurocognitive effect of six ketamine infusions in patients with anxious and nonanxious TRD and to determine the association between baseline neurocognition and changes in symptoms after the infusions. Method Patients with anxious (n = 30) and n...
#1Wei Zheng (Guangzhou Medical University)H-Index: 110
#2Wei Zheng (Guangzhou Medical University)H-Index: 11
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 9 authors...
Objective:Single-dose intravenous ketamine has rapid but time-limited antidepressant effects. We aimed to examine the sustained effects of six consecutive ketamine infusions in Chinese patients wit...
#1Weijian Liu (Southern Medical University)
#2Yanling Zhou (Guangzhou Medical University)H-Index: 4
Last.Yuping Ning (Southern Medical University)
view all 9 authors...
Abstract Background Major depressive disorder (MDD) is associated with neurocognitive impairment and reduced social-occupational function. However, neurocognition and social-occupational function in patients with anxious depression have been under-investigated. An increasing number of studies have demonstrated that neurocognition plays an important role in social-occupational function. The objective of this study was to investigate the association of severity of symptoms, neurocognition and soci...
#1Wei Zheng (Guangzhou Medical University)H-Index: 110
#2Wei Zheng (Guangzhou Medical University)H-Index: 11
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 9 authors...
Abstract Objective Ketamine has demonstrated a rapid antidepressant and antisuicidal effect in patients with major depressive disorder (MDD), but the neurocognitive effects of ketamine are relatively unknown. This study aims to examine the neurocognitive effects of six ketamine infusions and the association of baseline neurocognitive function and the change in severity of depressive symptoms after the last infusions. Methods Sixty-four patients with MDD completed six intravenous infusions of ket...
#1Yanling Zhou (Guangzhou Medical University)H-Index: 4
#2Wei Zheng (Guangzhou Medical University)H-Index: 110
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 8 authors...
Abstract Objective Cognitive impairment is common among patients with major depressive disorder (MDD), but its pathological mechanism is complex and not fully understood. Evidence suggests that the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression, but few studies have explored the association between the KYN pathway and cognitive impairment in MDD. Our aim was to examine the relationship between cognitive impairment and KYN pathway metabolites in patients with MDD....
#1Yujie Wu (Guangzhou Medical University)H-Index: 1
#2Naikeng Mai (Guangzhou Medical University)H-Index: 2
Last.Yuping Ning (Guangzhou Medical University)H-Index: 11
view all 12 authors...
Abstract Kynurenine pathway (KP) activation is associated with many neuropsychiatric diseases, such as major depressive disorder (MDD) and Alzheimer's disease (AD). Investigations conducted on MDD seldom shed light on KP changes in late-life depression (LLD), though memory deficit (MD) in patients with LLD is a predictable sign of AD. Thus, we aimed to investigate whether tryptophan (TRP) metabolism and kynurenine (KYN) metabolism were imbalanced in patients with LLD with MD and in patients with...
#1Xiaoyin Ke (Guangzhou Medical University)H-Index: 1
#2Yi Ding (Guangzhou Medical University)H-Index: 4
Last.Ni Fan (Guangzhou Medical University)H-Index: 6
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Abstract The aim of this study was to examine the cognitive function in chronic ketamine users. Factors correlated to cognition impairments were analyzed. Sixty-three chronic ketamine users and 65 healthy subjects were recruited. Cognitive function was assessed by using immediate/delayed visual reproduction (IVR/DVR) tasks, immediate/delayed logical memory (ILM/DLM) tasks, Stroop test, Wisconsin card sorting test (WCST), and continuous performance test (CPT). Psychopathological symptoms were ass...
#1Minling Zhang (Guangzhou Medical University)H-Index: 4
#2Robert A. Rosenheck (Yale University)H-Index: 94
Last.Hongbo He (Guangzhou Medical University)H-Index: 8
view all 9 authors...
Abstract Background Electroconvulsive therapy (ECT) is a rapid acting and effective treatment for both major depressive disorder (MDD) and bipolar disorder (BP). Both propofol and ketamine are commonly used anesthetic agents but recent clinical studies suggest that ketamine has rapid-acting antidepressant properties, itself, at sub-anesthetic doses. Methods A total of 77 inpatients (41 MDD and 36 BP) were randomly assigned to receive ECT with propofol (1 mg/kg) anesthesia or with ketamine (0.5 m...
#1Xingbing Huang (Guangzhou Medical University)H-Index: 2
#2Xiong Huang (Guangzhou Medical University)H-Index: 2
Last.Xiang Yang Zhang (PKU: Peking University)H-Index: 40
view all 8 authors...
Abstract The neurotrophic hypothesis of depression is supported by consistent findings of lower serum BDNF levels in depressed patients. Increasing evidence shows different clinical characteristics of patients with psychotic major depression versus nonpsychotic major depression. However, the possible association between BDNF and psychotic symptoms in depression has not been investigated. We recruited 90 treatment-resistant depression (TRD) patients and 90 gender- and age-matched healthy control ...
#1Yanling Zhou (Guangzhou Medical University)H-Index: 4
#2Robert A. Rosenheck (Yale University)H-Index: 94
Last.Hongbo He (Guangzhou Medical University)H-Index: 8
view all 5 authors...
Abstract Medication discontinuation is a major risk factor for relapse in schizophrenic patients. The present study investigated the rate and clinical correlates of complete medication discontinuation in the year after hospital discharge. Data collected from 236 schizophrenia patients who were prescribed anti-psychotics documented socio-demographic characteristics, symptom severity, insight, and attitudes towards medication in the week before their discharge and the experience of caregiver burde...
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