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Gregory O. Clark
University of Texas Southwestern Medical Center
5Publications
4H-index
616Citations
Publications 5
Newest
#1Chandna Vasandani (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
#2Gregory O. Clark (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
Last.Abhimanyu Garg (UTSW: University of Texas Southwestern Medical Center)H-Index: 12
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OBJECTIVE To study the efficacy and safety of metreleptin therapy in patients with suboptimally controlled type 1 diabetes mellitus (T1DM). RESEARCH DESIGN AND METHODS After a baseline period of 4 weeks, five female and three male patients with T1DM (mean age 33 years, BMI 23.8 kg/m 2 ) received metreleptin (0.08 mg/kg/day in females and 0.04 mg/kg/day in males) subcutaneously twice daily for 20 weeks followed by an off-therapy period of 4 weeks. RESULTS Metreleptin therapy did not lower HbA 1c ...
9 CitationsSource
#1May-Yun Wang (UTSW: University of Texas Southwestern Medical Center)H-Index: 30
#2Xinxin Yu (UTSW: University of Texas Southwestern Medical Center)H-Index: 11
Last.Philip Raskin (UTSW: University of Texas Southwestern Medical Center)H-Index: 75
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Abstract Aims Insulin is lipogenic and may invoke inflammation. We wished to determine if well controlled human and mice with type 1 diabetes had iatrogenic hyperinsulinemia as an explanation for the increased rate of coronary artery disease (CAD) in type 1 diabetes. Methods Type 1 diabetic subjects with HbA1C less than 7.0% had plasma insulin measured before and one hour after a Boost® challenge and a dose of subcutaneously administered insulin. These levels were compared with non-diabetic huma...
17 CitationsSource
#1May-Yun WangH-Index: 30
#2Lijun Chen (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
Last.Roger H UngerH-Index: 114
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In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic state through suppression of hyperglucagonemia. Additionally, it mimics the anabolic actions of insulin monotherapy and normalizes hemoglobin A1c with far less glucose variability. We show that leptin therapy, like insulin, normalizes the levels of a wide array of hepatic intermediary metabolites in multiple chemical classes, including acylcarnitines, organic...
239 CitationsSource
#1Roger H UngerH-Index: 114
#2Gregory O. ClarkH-Index: 4
Last.Lelio Orci (University of Geneva)H-Index: 121
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Abstract In the 20th century industrialized nations have become afflicted with an unprecedented pandemic of increased adiposity. In the United States, the epicenter of the epidemic, over 2/3 of the population, is overweight and 1 of every 6 Americans carries the diagnosis of metabolic syndrome. Although genes determine susceptibility to environmental factors, the epidemic is clearly due to increased consumption of calorie-dense, highly lipogenic foods, coupled with a marked decrease in physical ...
348 CitationsSource
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