David F. Ransohoff
University of North Carolina at Chapel Hill
Publications 196
#1Paulina WieszczyH-Index: 4
#2Michal F. Kaminski (Oslo University Hospital)H-Index: 17
Last.Urszula WojciechowskaH-Index: 5
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Abstract: Background & Aims Recommendation of surveillance colonoscopy should be based on risk of colorectal cancer and death after adenoma removal. We aimed to develop risk classification system based on colorectal cancer incidence and mortality following adenoma removal. Methods We performed a multicenter population-based cohort study of 236,089 individuals (median patient age, 56 years; 37.8% male) undergoing screening colonoscopies with adequate bowel cleansing and cecum intubation at 132 ce...
#1Suhas Vasaikar (BCM: Baylor College of Medicine)H-Index: 8
#2Chen Huang (BCM: Baylor College of Medicine)
Last.Zhiao Shi (BCM: Baylor College of Medicine)
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Summary We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens. Proteogenomic integration not only prioritized genomically inferred targets, such as copy-number drivers and mutation-derived neoantigens, but ...
#1M. J. Gunter (IARC: International Agency for Research on Cancer)H-Index: 43
#2S AlhomoudH-Index: 1
Last.Robert N. Hoover (NIH: National Institutes of Health)H-Index: 119
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#1Henriette C. Jodal (University of Oslo)H-Index: 1
#2Magnus Løberg (University of Oslo)H-Index: 14
Last.Mette Kalager (Harvard University)H-Index: 19
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Background & Aims Endoscopic screening for colorectal cancer (CRC) is performed at longer time intervals than the fecal occult blood test or screenings for breast or prostate cancer. This causes concerns about interval cancers, which have been proposed to progress more rapidly. We compared outcomes of patients with interval CRCs after sigmoidoscopy screening vs outcomes of patients with CRC who had not been screened. Methods We performed a secondary analysis of a randomized sigmoidoscopy screeni...
#1David L. DeMets (UW: University of Wisconsin-Madison)H-Index: 72
#2Thomas R. Fleming (UW: University of Washington)H-Index: 71
Last.David F. Ransohoff (UNC: University of North Carolina at Chapel Hill)H-Index: 60
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When there have been substantial failures by institutional leadership in their oversight responsibility to protect research integrity, the public should demand that these be recognized and addressed by the institution itself, or the funding bodies. This commentary discusses a case of research failures in developing genomic predictors for cancer risk assessment and treatment at a leading university. In its review of this case, the Office of Research Integrity, an agency within the US Department o...
#1Thomas F. Imperiale (IU: Indiana University)H-Index: 42
#2David F. Ransohoff (UNC: University of North Carolina at Chapel Hill)H-Index: 60
#1Thomas F. Imperiale (IU: Indiana University)H-Index: 42
#2Menggang Yu (IU: Indiana University)H-Index: 29
Last.David F. Ransohoff (UNC: University of North Carolina at Chapel Hill)H-Index: 60
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#1Nicholas J. ShaheenH-Index: 62
#2David F. RansohoffH-Index: 60
Context Gastroesophageal reflux disease (GERD) is a risk factor for adenocarcinoma of the esophagus, a rare cancer whose incidence is increasing. Adenocarcinoma may develop from Barrett esophagus, a metaplastic change of the esophageal epithelium from squamous to intestinalized columnar mucosa, which is associated with chronic reflux. Some have recommended that patients with chronic reflux symptoms undergo upper endoscopy to assess for Barrett esophagus and to screen for cancer. Objectives To re...