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Xuan Zhou
University of South Australia
Circadian rhythmPsychologySleep deprivationPsychomotor vigilance taskSleep restriction
29Publications
13H-index
456Citations
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Publications 29
Newest
#1Buu Truong (Pham Ngoc Thach University of Medicine)H-Index: 1
#2Xuan Zhou (UniSA: University of South Australia)H-Index: 13
Last. S. Hong Lee (UniSA: University of South Australia)H-Index: 18
view all 7 authors...
Polygenic risk scores are emerging as a potentially powerful tool to predict future phenotypes of target individuals, typically using unrelated individuals, thereby devaluing information from relatives. Here, for 50 traits from the UK Biobank data, we show that a design of 5,000 individuals with first-degree relatives of target individuals can achieve a prediction accuracy similar to that of around 220,000 unrelated individuals (mean prediction accuracy = 0.26 vs. 0.24, mean fold-change = 1.06 (...
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#1Xuan Zhou (UniSA: University of South Australia)H-Index: 13
#2Julius H. J. van der Werf (UNE: University of New England (Australia))H-Index: 21
Last. S. Hong Lee (UniSA: University of South Australia)H-Index: 1
view all 7 authors...
Background Both genetic and nongenetic factors can predispose individuals to cardiovascular risk. Finding ways to alter these predispositions is important for cardiovascular disease prevention. Methods and Results We used a novel whole-genome approach to estimate the genetic and nongenetic effects on-and hence their predispositions to-cardiovascular risk and determined whether they vary with respect to lifestyle factors such as physical activity, smoking, alcohol consumption, and dietary intake....
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#1Xuan Zhou (UniSA: University of South Australia)H-Index: 13
#2Hae Kyung Im (U of C: University of Chicago)H-Index: 28
Last. S. Hong Lee (UniSA: University of South Australia)
view all 3 authors...
Linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) are a key variance partitioning tool, where effects of multiple sources, such as different functional genomic regions, on phenotypes are treated as random. Classic LMMs assume independence between random effects, which can cause biased estimation of variance components. Here, we relax this independence assumption by introducing a generalised GREML, called CORE GREML, that can explicitly estimate the covariance be...
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#1Guiyan Ni (UNE: University of New England (Australia))
#1Guiyan Ni (UNE: University of New England (Australia))H-Index: 4
Last. S. Hong Lee (UniSA: University of South Australia)H-Index: 18
view all 6 authors...
Female reproductive behaviours have important implications for evolutionary fitness and health of offspring. Here we used the second release of UK Biobank data (N = 220,685) to evaluate the association between five female reproductive traits and polygenic risk scores (PRS) projected from genome-wide association study summary statistics of six psychiatric disorders (N = 429,178). We found that the PRS of attention-deficit/hyperactivity disorder (ADHD) were strongly associated with age at first bi...
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#1Xuan Zhou (UniSA: University of South Australia)H-Index: 13
#2Julius H. J. van der Werf (UNE: University of New England (United States))H-Index: 21
Last. S. Hong Lee (UniSA: University of South Australia)H-Index: 1
view all 7 authors...
Abstract Both genetic and non-genetic factors can predispose individuals to cardiovascular risk. Finding ways to alter these predispositions is important for cardiovascular disease (CVD) prevention. Here, we use a novel whole-genome framework to estimate genetic and non-genetic effects on—hence their predispositions to—cardiovascular risk and determine whether they vary with respect to lifestyle factors. We performed analyses on the Atherosclerosis Risk in Communities Study (ARIC, N=6,896-7,180)...
Source
#1Guiyan Ni (UNE: University of New England (Australia))H-Index: 4
#2Julius H. J. van der Werf (UNE: University of New England (Australia))H-Index: 21
Last. S. Hong Lee (UNE: University of New England (Australia))H-Index: 18
view all 6 authors...
The genomics era has brought useful tools to dissect the genetic architecture of complex traits. Here we propose a multivariate reaction norm model (MRNM) to tackle genotype-covariate (G-C) correlation and interaction problems. We apply MRNM to the UK Biobank data in analysis of body mass index using smoking quantity as a covariate, finding a highly significant G-C correlation, but only weak evidence for G-C interaction. In contrast, G-C interaction estimates are inflated in existing methods. It...
4 CitationsSource
#1Guiyan Ni (UniSA: University of South Australia)H-Index: 4
#2Azmeraw T. AmareH-Index: 45
Last. S. Hong Lee (UniSA: University of South Australia)H-Index: 34
view all 6 authors...
Female reproductive behaviors have an important implication in evolutionary fitness and health of offspring. Previous studies have shown that age at first birth of women (AFB) is genetically associated with schizophrenia (SCZ). However, for most other psychiatric disorders and reproductive traits, the latent shared genetic architecture is largely unknown. Here we used the second wave of UK Biobank data (N=220,685) to evaluate the association between five female reproductive traits and polygeneti...
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#1Yoojae Maeng (WMU: Wenzhou Medical College)H-Index: 1
#2Kyoung Tae Kim (WMU: Wenzhou Medical College)H-Index: 2
Last. Xiaokun Li (WMU: Wenzhou Medical College)H-Index: 51
view all 12 authors...
: Horse oil contains linoleic, palmitoleic and unsaturated fatty acids that are similar to those in human skin, and may therefore be an ideal substance from which to isolate biosurfactants for cosmetic products to improve human skin quality. Herein, an innovative approach was developed to synthesise sophorolipids from horse oil by hydrolysis, followed by fermentation using the yeast Candida bombicola. The yield of sophorolipids from direct fermentation of horse oil and hydrolysed horse oil was 4...
2 CitationsSource
#1Guiyan Ni (UniSA: University of South Australia)H-Index: 4
#2Julius H. J. van der Werf (UNE: University of New England (United States))H-Index: 21
Last. S. Hong Lee (UniSA: University of South Australia)H-Index: 34
view all 6 authors...
The genomics era has brought useful tools to dissect the genetic architecture of complex traits. We propose a reaction norm model (RNM) to tackle genotype-environment correlation and interaction problems in the context of genome-wide association analyses of complex traits. In our approach, an environmental risk factor affecting the trait of interest can be modeled as dependent on a continuous covariate that is itself regulated by genetic as well as environmental factors. Our multivariate RNM app...
4 CitationsSource
#1Gregory D. Roach (Central Queensland University)H-Index: 30
#2Xuan Zhou (Central Queensland University)H-Index: 13
Last. Charli Sargent (Central Queensland University)H-Index: 24
view all 6 authors...
Abstract The aim of this study was to compare the quantity/quality of sleep obtained by people living on split and consolidated sleep–wake schedules. The study had a between-groups design, with 13 participants in a consolidated condition (all males, mean age of 22.5 yr) and 16 participants in a split condition (all males, mean age of 22.6 yr). Both conditions employed forced desynchrony protocols with the activity:rest ratio set at 2:1, but the consolidated condition had one sleep–wake cycle eve...
5 CitationsSource
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