David Baker
University of London
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Publications 1679
: Integrase strand transfer inhibitor-based antiretroviral therapy can cause weight gain. It is unknown if this is a class effect, with limited data regarding raltegravir. In 37 virologically suppressed adults (36 men, mean age 49 years) who switched from tenofovir disoproxil fumarate to raltegravir 400 mg twice daily, mean weight changes from baseline at weeks 24, 48 and 96 were not significant (maximum 0.8 kg at week 24; all P >/= 0.16). Weight gain may not occur with all integrase strand tran...
#1Hai Qiu Wu (LUMC: Leiden University Medical Center)
#2David Baker (LUMC: Leiden University Medical Center)H-Index: 156
Last. Huib Ovaa (LUMC: Leiden University Medical Center)H-Index: 51
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#1Peter ten Dijke (LUMC: Leiden University Medical Center)H-Index: 92
#2David Baker (LUMC: Leiden University Medical Center)H-Index: 156
#1Kathy Y. Wei (University of California, Berkeley)H-Index: 4
#2Danai Moschidi (UCSC: University of California, Santa Cruz)
Last. Scott E. Boyken (UW: University of Washington)H-Index: 10
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The plasticity of naturally occurring protein structures, which can change shape considerably in response to changes in environmental conditions, is critical to biological function. While computational methods have been used for de novo design of proteins that fold to a single state with a deep free-energy minimum [P.-S. Huang, S. E. Boyken, D. Baker, Nature 537, 320–327 (2016)], and to reengineer natural proteins to alter their dynamics [J. A. Davey, A. M. Damry, N. K. Goto, R. A. Chica, Nat. C...
#1Konstantinos Koussis (Francis Crick Institute)H-Index: 4
#2Chrislaine Withers-Martinez (Francis Crick Institute)H-Index: 23
Last. Michael J. Blackman (Lond: University of London)H-Index: 51
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Over recent years, a plethora of new genetic tools has transformed conditional engineering of the malaria parasite genome, allowing functional dissection of essential genes in the asexual and sexual blood stages that cause pathology or are required for disease transmission, respectively. Important challenges remain, including the desirability to complement conditional mutants with a correctly regulated second gene copy to confirm that observed phenotypes are due solely to loss of gene function a...
#1Anna Isaacs‐Ten (Norwich University)
#2Marta Echeandia (Norwich University)H-Index: 1
Last. David Baker (Norwich University)H-Index: 156
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Mounting evidence supports an association between cholestatic liver disease and changes in the composition of the microbiome. Still, the role of the microbiome in the pathogenesis of this condition remains largely undefined. To address this, we have used two experimental models, administering ANIT or feeding a 0.1%DDC diet, to induce cholestatic liver disease in germ-free mice and germ-free mice conventionalized with the microbiome from WT SPF animals. Next, we have inhibited macrophage activati...
#1Andrew H. NgH-Index: 6
#2Taylor H. Nguyen (UCSF: University of California, San Francisco)H-Index: 2
Last. David Baker (UW: University of Washington)H-Index: 156
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#1Liaqat Ali (QMUL: Queen Mary University of London)
#2Gauri Saxena (QMUL: Queen Mary University of London)H-Index: 1
Last. Angray S. Kang (QMUL: Queen Mary University of London)H-Index: 26
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Aim: The humanized anti-CD52 monoclonal antibody alemtuzumab depletes lymphocytes and is currently used to treat relapsing multiple sclerosis. During treatment, anti-alemtuzumab antibodies may deve...
#1Ryan C. Henrici (Lond: University of London)H-Index: 2
#2Rachel L. Edwards (WashU: Washington University in St. Louis)H-Index: 5
Last. Christian Flueck (Lond: University of London)H-Index: 6
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ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin encodes the μ subunit of the AP-2 adaptin trafficking complex. To elucidate the cellular role of AP-2μ in P. falciparum, we performed a conditional gene knockout, which severely disrupted schizont organization and maturation, leading to mislocalization o...
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