Zheng Dong
Central South University
ApoptosisKidneyCancer researchBiologyCell biology
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Publications 278
#1Yuxue Liu (CSU: Central South University)H-Index: 2
#2Ying Fu (CSU: Central South University)H-Index: 1
Last. Zheng Dong (Charlie Norwood VA Medical Center)H-Index: 54
view all 8 authors...
Renal ischemia-reperfusion is a major cause of acute kidney injury, a disease currently without effective treatments. Irisin was initially identified as an important factor produced by muscles to mediate the health benefits of exercise, and recent work has further suggested its protective effect against lung and liver injury. However, the role of Irisin in kidney diseases, including renal ischemia-reperfusion injury (IRI), remains unknown. In the present study, we found that the Irisin precursor...
#1Jiefu ZhuH-Index: 5
Last. Zheng DongH-Index: 54
view all 9 authors...
#1Shengmin Yan (Tulane University)
#2Bilon Khambu (Tulane University)
Last. Xiao-Ming Yin (Tulane University)
view all 6 authors...
Objective: The gut microbiota (GM) can have complicated and often undetermined interactions with the function of many organs in the body. GM is altered in a variety of liver diseases, but the significance of such changes on the liver disease is still unclear. Hepatic autophagy deficiency causes liver injury accompanied with cholestasis. Here, we investigated the impact of such hepatic changes on GM and in turn the effect of gut dysbiosis on liver injury. Design: Fecal microbiota from mice with l...
#1Charles L. Edelstein (Anschutz Medical Campus)H-Index: 59
#2Manjeri A. Venkatachalam (University of Texas Health Science Center at San Antonio)H-Index: 51
Last. Zheng Dong (Charlie Norwood VA Medical Center)H-Index: 54
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1 CitationsSource
#1Bilon Khambu (IU: Indiana University)H-Index: 11
#2Honghai Hong (IU: Indiana University)H-Index: 1
Last. Xiao-Ming Yin (IU: Indiana University)H-Index: 61
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Autophagy is an intracellular lysosomal degradative pathway important for tumor surveillance. Autophagy deficiency can lead to tumorigenesis. Autophagy is also known to be important for the aggressive growth of tumors, yet the mechanism that sustains the growth of autophagy-deficient tumors is not unclear. We previously reported that progression of hepatic tumors developed in autophagy-deficient livers required high mobility group box 1 (HMGB1), which was released from autophagy-deficient hepato...
#1Yaohui Wang (Henan University)H-Index: 3
#2Hailong Zhang (Henan University)H-Index: 8
Last. Dongmei Zhao (Henan University)H-Index: 1
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Myocardial infarction (MI) is a leading cause of death worldwide for which there is no cure. Although cardiac cell death is a well-recognized pathological mechanism of MI, therapeutic blockade of cell death to treat MI is not straightforward. Death receptor 5 (DR5) and its ligand TRAIL [tumor necrosis factor (TNF)–related apoptosis-inducing ligand] are up-regulated in MI, but their roles in pathological remodeling are unknown. Here, we report that blocking TRAIL with a soluble DR5 immunoglobulin...
1 CitationsSource
#1Jiefu Zhu (Georgia Regents University)H-Index: 1
#1Jiefu Zhu (CSU: Central South University)H-Index: 5
Last. Zheng Dong (Georgia Regents University)H-Index: 54
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BACKGROUND: Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C-delta (PKCdelta) in renal tubular injury during cisplatin nephrotoxicity and albumin-associated kidney injury, but whether PKCdelta is involved in ischemic or transplantation-associated kidney injury is unknown. METHODS: To investigate PKCdelta's potentia...
1 CitationsSource
#1Jinxian Xu (Georgia Regents University)
#2Xinglou Liu (Georgia Regents University)
Last. Ming Zhang (Georgia Regents University)H-Index: 10
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Age-related macular degeneration (AMD) is a complex, multifactorial, progressive disease, which represents a leading cause of irreversible visual impairment and blindness in older individuals. Human cytomegalovirus (HCMV), which infects 50 to 80% of humans, is usually acquired during early life and persists in a latent state for the life of the individual. In view of its previously described pro-angiogenic properties, we hypothesized that cytomegalovirus might be a novel risk factor for progress...
#1Zhixia SongH-Index: 1
#2Jiefu Zhu (CSU: Central South University)H-Index: 5
Last. Zheng Dong (Charlie Norwood VA Medical Center)H-Index: 54
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Cisplatin is a widely used chemotherapy drug with notorious nephrotoxicity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of novel anti-diabetic agents that may have other effects in kidneys besides blood glucose control. In this study, we demonstrate that canagliflozin significantly attenuated cisplatin-induced nephropathy in C57BL/6 mice and suppressed cisplatin induced renal proximal tubular cell apoptosis in vitro. The protective effect of canagliflozin was associated with th...
#1Yu Yan (CSU: Central South University)H-Index: 1
#2Zhengwei Ma (Georgia Regents University)H-Index: 1
Last. Zheng Dong (CSU: Central South University)H-Index: 54
view all 6 authors...
Disruption of mitochondrial dynamics is an important pathogenic event in both acute and chronic kidney diseases, but the underlying mechanism remains poorly understood. Here we report the regulatio...
2 CitationsSource