Olivier Neyrolles
University of Toulouse
ImmunologyMycobacterium tuberculosisTuberculosisBiologyMicrobiology
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Publications 144
#2Olivier NeyrollesH-Index: 41
Last. Yoann RomboutsH-Index: 21
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#1Florence Levillain (University of Toulouse)H-Index: 11
#2Hongmin Kim (Yonsei University)H-Index: 9
Last. Olivier Neyrolles (University of Toulouse)H-Index: 41
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Abstract Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgently needed. One of the challenges for novel TB vaccines is to protect against all Mycobacterium tuberculosis lineages, including the most virulent ones, such as the Beijing lineage. Here we developed a live attenuated M. tuberculosis mutant derived from GC1237, a Beijing strain responsible for tuberculosis outbreaks in the Canary Islands. The mutant strain is inactivated both in the Rv150...
#1Yves-Marie Boudehen (University of Toulouse)H-Index: 1
#2Maximilian Wallat (University of Toulouse)
Last. Claude Gutierrez (University of Toulouse)H-Index: 9
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Xer-cise is a technique using antibiotic resistance cassettes flanked by dif sites allowing spontaneous and accurate excision from bacterial chromosomes with a high frequency through the action of ...
#1Martina Pirro (LUMC: Leiden University Medical Center)
#2Yoann Rombouts (University of Toulouse)H-Index: 21
Last. Paul J. Hensbergen (LUMC: Leiden University Medical Center)H-Index: 30
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Abstract Background The Ca2+-dependent C-type lectin receptor Macrophage Galactose-type Lectin (MGL) is highly expressed by tolerogenic dendritic cells (DC) and macrophages. MGL exhibits a high binding specificity for terminal alpha- and beta-linked GalNAc residues found in Tn, sTn and LacdiNAc antigens. These glycan epitopes are often overexpressed in colorectal cancer (CRC), and, as such, MGL can be used to discriminate tumor from the corresponding healthy tissues. Moreover, the high expressio...
#1Giulia Trimaglio (University of Toulouse)
#2Anne-Françoise Tilkin-Mariamé (French Institute of Health and Medical Research)H-Index: 6
Last. Christel Devaud (French Institute of Health and Medical Research)
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Background: Immunotherapies have achieved clinical benefit in many types of cancer but remain limited to a subset of patients in colorectal cancer (CRC). Resistance to immunotherapy can be attributed in part to tissue-specific factors constraining antitumor immunity. Thus, a better understanding of how the colon microenvironment shapes the immune response to CRC is needed to identify mechanisms of resistance to immunotherapies and guide the development of novel therapeutics. Methods: In an ortho...
#1Melanie Genoula (Academia Nacional de Medicina)H-Index: 1
#2José Luis Marin Franco (Academia Nacional de Medicina)H-Index: 1
Last. Luciana Balboa (Academia Nacional de Medicina)H-Index: 12
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The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM). Indeed, FM are favorable to Mtb. The activation state of macrophages is tightly associated to different metabolic pathways, such as lipid metabolism, but whether differentiation towards FM differs between the macrophage activation profiles remains unclear. Here, we aimed to elucidate if distinct macrophag...
#1Christel Vérollet (University of Toulouse)H-Index: 14
#2Maeva Dupont (University of Toulouse)H-Index: 3
Last. Geanncarlo Lugo-Villarino (University of Toulouse)H-Index: 19
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While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis worsens HIV-1 pathogenesis remain poorly understood. Recently, we showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. To identify factors associated with TNT, we performed a transcriptome analysis in these macrophages, and revealed the up-regulation of Siglec-1. We demonstrate Siglec-...
#1Shanti SouriantH-Index: 4
#2Maeva DupontH-Index: 3
Last. Christel VérolletH-Index: 14
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#1Davie Cappoen (University of Antwerp)H-Index: 7
#2Eveline Torfs (University of Antwerp)H-Index: 2
Last. Paul Cos (University of Antwerp)H-Index: 39
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Abstract Tuberculosis (TB) still has a major impact on public health. In order to efficiently eradicate this life-threatening disease, the exploration of novel anti-TB drugs is of paramount importance. As part of our program to design new 2-azaanthraquinones with anti-mycobacterial activity, various “out-of-plane” tetrahydro- and octahydrobenzo[ j ]phenanthridinediones were synthesized. In this study, the scaffold of the most promising hits was further optimized in an attempt to improve the bioa...
#1Miguel Palomino-Segura (USI: University of Lugano)H-Index: 2
#2Laurent Perez (USI: University of Lugano)H-Index: 15
Last. Santiago F. Gonzalez (USI: University of Lugano)H-Index: 21
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The early phase of influenza infection occurs in the upper respiratory tract and the trachea, but little is known about the initial events of virus recognition and control of viral dissemination by the immune system. Here, we report that inflammatory dendritic cells (IDCs) are recruited to the trachea shortly after influenza infection through type I interferon-mediated production of the chemokine CCL2. We further show that recruited IDCs express the C-type lectin receptor SIGN-R1, which mediates...
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