Matthew J. McQueen
McMaster University
Publications 79
#1Hertzel C. Gerstein (Population Health Research Institute)H-Index: 93
#2Guillaume Paré (McMaster University)H-Index: 52
Last.Sibylle HessH-Index: 4
view all 7 authors...
OBJECTIVE Diabetes is a major risk factor for renal function decline and failure. The availability of multiplex panels of biochemical markers provides the opportunity to identify novel biomarkers that can better predict changes in renal function than routinely available clinical markers. RESEARCH DESIGN AND METHODS The concentration of 239 biochemical markers was measured in stored serum from participants in the biomarker substudy of Outcomes Reduction with an Initial Glargine Intervention (ORIG...
#1Hertzel C. GersteinH-Index: 93
#2Guillaume ParéH-Index: 52
Last.Sibylle HessH-Index: 4
view all 6 authors...
Diabetes is the most common cause of renal failure accounting for more than 50% of cases. Whereas HbA1c, age and albuminuria are independent risk factors for renal decline, adding novel serum biomarkers to routine clinical risk factors may help identify patients at high risk for renal decline. One ml of stored serum from 7,482 ORIGIN participants with a recorded eGFR at baseline and either the 2 year and/or final visit was assayed for 237 biomarkers using Myriad RBM’s customized human discovery ...
#1Pedrum Mohammadi-Shemirani (McMaster University)H-Index: 1
#2Jennifer Sjaarda (McMaster University)H-Index: 3
Last.Guillaume ParéH-Index: 52
view all 9 authors...
Background: Identifying markers of chronic kidney disease (CKD) that occur early in the disease process and are specific to loss of kidney function rather than other underlying causes of disease may allow earlier, more accurate identification of patients who will develop CKD. We therefore sought to identify diagnostic blood markers of early CKD that are caused by loss of kidney function by using an innovative “reverse Mendelian randomization” (MR) approach. Methods: We applied this technique to ...
1 CitationsSource
#1Adriana Nori de Macedo (McMaster University)H-Index: 3
#2Joseph Macri (McMaster University)H-Index: 25
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
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Background: A capillary electrophoresis (CE) assay was recently introduced as a new method for monitoring iodine nutrition in large-scale epidemiological studies. However, further tests revealed unanticipated matrix-dependent interferences when analyzing submicromolar levels of iodide in human urine as the predominate ionic form of dietary iodine. Herein, we describe a rigorous validation study that was used to identify sources of bias and establish modifications to the original CE method to imp...
2 CitationsSource
#1Philip J. Devereaux (McMaster University)H-Index: 74
#2Bruce M Biccard (UCT: University of Cape Town)H-Index: 27
Last.Gordon H. Guyatt (McMaster University)H-Index: 201
view all 53 authors...
Importance Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Objective To determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS (ie, myocardial injury due to ischemia associated with 30-day mortality). Design, Setting, and Participants Prospective cohort study of patients aged 45 years ...
114 CitationsSource
#1Andrew Mente (McMaster University)H-Index: 32
#2Gilles R. DagenaisH-Index: 64
Last.Koon K. Teo (McMaster University)H-Index: 82
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Abstract Background Although salt intake derived from data on urinary sodium excretion in free-living populations has been used in public policy, a population study on urinary sodium excretion has not been done in Canada. We assessed dietary sodium and potassium intake using a 24-hour urine collection in a large survey of urban and rural communities from 4 Canadian cities and determined the association of these electrolytes with blood pressure (BP). Methods One thousand seven hundred consecutive...
13 CitationsSource
Objective—Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the modulation of low-density lipoprotein metabolism. This study was conducted to evaluate the relationship between serum PCSK9 concentrations and measures of vascular health, subclinical atherosclerosis, and adverse cardiovascular events. The relationship between traditional risk factors and PCSK9 concentrations was also examined. Approach and Results—The cohort consisted of 1527 middle-aged men enrolled ...
32 CitationsSource
#1Andrew Mente (McMaster University)H-Index: 32
#2Kenneth R. Chalcraft (McMaster University)H-Index: 6
Last.Matthew J. McQueen (McMaster University)H-Index: 28
view all 10 authors...
Abstract Background Microflora-dependent trimethylamine-N-oxide (TMAO) formation, which results from intake of choline and L-carnitine-rich food, shows promise as a predictor of cardiovascular disease (CVD) risk, but these associations have not been examined in ethnically diverse populations. In a multiethnic population-based study of adults in Canada, we assessed the stability of TMAO and L-carnitine in stored serum samples and their association with intimal medial thickness, prevalent risk fac...
42 CitationsSource
#1Shirya Rashid (Dal: Dalhousie University)H-Index: 8
#2Allan D. Sniderman (McGill University)H-Index: 66
Last.Salim Yusuf Mb Bs DPhil Frcpc (McMaster University)H-Index: 214
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AimsWhy South Asians are at increased risk of premature atherosclerotic cardiovascular diseases compared with other ethnic groups is not fully understood. Atherogenic dyslipoproteinemia – hypertriglyceridemia, elevated numbers of low-density lipoprotein (LDL) particles and low high-density lipoprotein cholesterol (HDL-C) – is more common in South Asians but the mechanisms responsible have not been explicated. Here we examined whether the circulating lipid transfer protein, cholesteryl ester tran...
11 CitationsSource
#1David E. Bruns (UVA: University of Virginia)H-Index: 31
#2Carl A. Burtis (ORNL: Oak Ridge National Laboratory)H-Index: 13
Last.Jon J. Jonsson (University of Iceland)H-Index: 20
view all 6 authors...
Abstract Background Ethical considerations are increasingly important in medicine. We aimed to determine the mode and extent of teaching of ethics in training programs in clinical chemistry and laboratory medicine. Methods We developed an on-line survey of teaching in areas of ethics relevant to laboratory medicine. Reponses were invited from directors of training programs who were recruited via email to leaders of national organizations. Results The survey was completed by 80 directors from 24 ...
8 CitationsSource