Hu Häring
University of Tübingen
EndocrinologyInsulin resistanceInsulinDiabetes mellitusMedicine
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Publications 1116
#1Stephanie Kullmann (University of Tübingen)H-Index: 25
#2Vera Valenta (University of Tübingen)
Last. Martin Heni (University of Tübingen)H-Index: 30
view all 9 authors...
Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain insulin resistant. How brain insulin responsiveness affects long-term weight and body fat composition in humans is still unknown. Here we show that high brain insulin sensitivity before lifestyle intervention associates with a more pronounced reduction in total and visceral fat during the program. High brain insulin sensitivity is also associated with less regain of fat mass d...
#1Chunxiu Hu (DICP: Dalian Institute of Chemical Physics)H-Index: 17
#2Miriam HoeneH-Index: 16
Last. Cora Weigert (University of Tübingen)H-Index: 37
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CONTEXT: The liver is crucial to maintain energy homeostasis during exercise. Skeletal muscle-derived metabolites can contribute to the regulation of hepatic metabolism. OBJECTIVE: We aim to elucidate which metabolites are released from the working muscles and taken up by the liver in exercising humans and their potential influence on hepatic function. METHODS: In two separate studies, young healthy men fasted overnight and then performed an acute bout of exercise. Arterial-to-venous differences...
1 CitationsSource
#1Florian Härtig (University of Tübingen)H-Index: 7
#2Sven Poli (University of Tübingen)H-Index: 18
Last. Sebastian Hörber (University of Tübingen)H-Index: 3
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The direct oral anticoagulant dabigatran does not require therapeutic drug monitoring, however emergency measurements are gaining importance. Current assays feature good performance at intermediate and high dabigatran concentrations but show limited accuracy at low concentrations. This area requires more attention as clinical decision threshold values currently lie at 30 and 50 ng/ml. The objective of the study was to evaluate and compare diagnostic performance of dabigatran assays at these thre...
#1Sebastian Hörber (University of Tübingen)H-Index: 3
#2Angela Lehn-Stefan (University of Tübingen)H-Index: 7
Last. Elko Randrianarisoa (University of Tübingen)H-Index: 6
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Background Type 2 diabetes mellitus (T2DM) promotes the development of atherosclerosis and is a major risk factor for cardiovascular disease. High-sensitivity cardiac troponin I (hs-cTnI) assays fundamentally improved the diagnosis of myocardial injury and even enable the prediction of future cardiovascular events in the general population. However, data about the association of hs-cTnI with cardiovascular risk factors and carotid intima media thickness (cIMT) as a marker of atherosclerosis are ...
#1Hany F. Sobhi (Coppin State University)H-Index: 4
#2Xin-JieZhao (DICP: Dalian Institute of Chemical Physics)H-Index: 32
Last. Sean H. Adams (University of Arkansas for Medical Sciences)H-Index: 34
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Little is known about xenometabolites in human metabolism, particularly under exercising conditions. Previously, an exercise-modifiable, likely xenometabolite derivative, cis-3,4-methylene-heptanoy...
#1Susanne NeschenH-Index: 28
#2Moya WuH-Index: 4
Last. Tina Sartorius (University of Tübingen)H-Index: 14
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Aims and Methods Glucose homeostasis and energy balance are under control by peripheral and brain processes. Especially insulin signaling in the brain seems to impact whole body glucose homeostasis and interacts with fatty acid signaling. In humans circulating saturated fatty acids are negatively associated with brain insulin action while animal studies suggest both positive and negative interactions of fatty acids and insulin brain action. This apparent discrepancy might reflect a difference be...
#1Haliza Mat Husin (University of Tübingen)H-Index: 1
#2Franziska Schleger (University of Tübingen)H-Index: 7
Last. Hubert PreisslH-Index: 44
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OBJECTIVE: Prepregnancy obesity and extensive weight gain can lead to diseases in the offspring later in life. The aim of this study was to evaluate the effect of anthropometric and metabolic factors on the fetal autonomic nervous system (ANS) in uncomplicated pregnancies. METHODS: A total of 184 pregnant women in the second or third trimester were included, and for 104 women, maternal insulin sensitivity (ISI) was determined. Fetal heart rate (HR) and heart rate variability (HRV) were determine...
2 CitationsSource
#1Francesco Volta (TUM: Technische Universität München)H-Index: 2
Last. Jantje GerdesH-Index: 5
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Diabetes mellitus affects one in eleven adults worldwide. Most suffer from Type 2 Diabetes which features elevated blood glucose levels and an inability to adequately secrete or respond to insulin. Insulin producing β-cells have primary cilia which are implicated in the regulation of glucose metabolism, insulin signaling and secretion. To better understand how β-cell cilia affect glucose handling, we ablate cilia from mature β-cells by deleting key cilia component Ift88. Here we report that gluc...
2 CitationsSource
#1Martin HeniH-Index: 30
#2Robert WagnerH-Index: 17
Last. Andreas FritscheH-Index: 72
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