Hu Häring
University of Tübingen
Publications 1086
#1Anja Schork (University of Tübingen)H-Index: 3
Last.Ferruh Artunc (University of Tübingen)H-Index: 22
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Background SGLT2-inhibitors are potent antihyperglycemic drugs for patients with type 2 diabetes and have been shown to reduce body weight. However, it is unclear which body compartments are reduced and to what extent.
#1Katarzyna Linder (University of Tübingen)H-Index: 12
#2Caroline Willmann (University of Tübingen)
Last.Norbert Stefan (University of Tübingen)H-Index: 59
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Niacin inhibits fatty acid flux from adipose tissue to liver, reduces hepatic triglyceride synthesis and increases hepatic lipid oxidation. Thus, niacin may have a role in the regulation of liver fat content in humans. We tested if dietary intake of niacin predicts change of liver fat content during a lifestyle intervention. To this end, we estimated the composition of diet from diaries of 202 healthy subjects at risk of type 2 diabetes undergoing lifestyle intervention comprising physical activ...
#1Estela Lorza-Gil (University of Tübingen)H-Index: 2
#2F Gerst (University of Tübingen)H-Index: 8
Last.Susanne Ullrich (University of Tübingen)H-Index: 20
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Isolated human islets do not always meet the quality standards required for transplant survival and reliable functional in vitro studies. The formation of pseudoislets, i.e. the reaggregation of a defined number of islet cells after dissociation, improves insulin secretion. We present a simple method of pseudoislet formation from human islet cells and assess the transcriptome and function of isolated human islets and pseudoislets from the same organ donors. Following pseudoislet formation, insul...
#1Andras FrankoH-Index: 8
#2Sonja HartwigH-Index: 17
Last.Andreas PeterH-Index: 29
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The liver plays a pivotal role in whole-body carbohydrate, lipid, and protein metabolism. One of the key regulators of glucose and lipid metabolism are hepatokines, which are found among the liver secreted proteins, defined as liver secretome. To elucidate the composition of the human liver secretome and identify hepatokines in primary human hepatocytes (PHH), we conducted comprehensive protein profiling on conditioned medium (CM) of PHH. Secretome profiling using liquid chromatography-electrosp...
#1Xianming Wang (TUM: Technische Universität München)H-Index: 2
Last.Heiko LickertH-Index: 33
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Abstract Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic β-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method. The resulting iPSCs are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Furthermore, we show that this iPSC line can be differentiated into pancreatic lineage cells. Taken together, this iPSC line will be...
#1Lisa KapplerH-Index: 2
#2Miriam HoeneH-Index: 15
Last.Hans Zischka (TUM: Technische Universität München)H-Index: 30
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Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a syst...