Akiyoshi Namiki
Sapporo Medical University
Publications 731
#1Yuji Kozuka (Sapporo Medical University)H-Index: 6
#2Mikito Kawamata (Shinshu University)H-Index: 22
Last.Michiaki Yamakage (Sapporo Medical University)H-Index: 9
view all 7 authors...
BackgroundAfter spinal cord injury, central neuropathic pain develops in the majority of spinal cord injury patients. Spinal hemisection in rats, which has been developed as an animal model of spinal cord injury in humans, results in hyperexcitation of spinal dorsal horn neurons soon after the hemisection and thereafter. The hyperexcitation is likely caused by permanent elimination of the descending pain systems. We examined the change in synaptic transmission of substantia gelatinosa neurons fo...
1 CitationsSource
#1Shigekazu Sugino (Penn State Milton S. Hershey Medical Center)H-Index: 1
#2Tomo Hayase (Sapporo Medical University)H-Index: 6
Last.Piotr K. Janicki (Penn State Milton S. Hershey Medical Center)H-Index: 22
view all 9 authors...
Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (OPRM1) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the OPRM1 gene, and their association with PONV during the early (first 24 h) postoperative period. We...
8 CitationsSource
#1Junzo Takeda (Keio: Keio University)H-Index: 28
#2Akiyoshi Namiki (Sapporo Medical University)H-Index: 38
Last.Baxter Blm Study Team (Baxter International)H-Index: 1
view all 19 authors...
The present study was conducted to evaluate the efficacy and safety of BLM-240 (desflurane) in comparison to sevoflurane in Japanese patients. A total of 216 patients were enrolled in this randomized comparative study at 15 medical institutions. The patients received either BLM-240 with 50–70 % N2O in O2 (n = 111), BLM-240 with 30 % O2 in air (n = 55), or sevoflurane with 50–70 % N2O in O2 (n = 50). Efficacy was evaluated by an efficacy rate based on an efficacy evaluation criteria and recovery ...
1 CitationsSource
#1N. MoriokaH-Index: 4
#2Makoto OzakiH-Index: 31
Last.Kiyoshi MoritaH-Index: 27
view all 9 authors...
Purpose: The primary aim of this study was to investigate volume effect and safety of up to 50 mL/kg BW 6% hydroxyethyl starch (HES) 130/0.4 in adult and pediatric patients undergoing major elective surgery. The need to infuse human albumin may be reduced or avoided in Japan if these large doses 6% HES 130/0.4 can be infused. Methods: The study was an uncontrolled, open-labeled, multi-center trial. Fifteen adult and 5 pediatric patients undergoing major elective surgery received 6% HES 130/0.4 (...
1 CitationsSource
#1Shigekazu Sugino (Sapporo Medical University)H-Index: 7
#2Akiyoshi Namiki (Sapporo Medical University)H-Index: 38
Last.Michiaki Yamakage (Sapporo Medical University)H-Index: 25
view all 3 authors...
Abstract Background Opioid sensitivity varies among individuals. Although opioids can act partly in the rostral ventromedial medulla (RVM), which has a major role in pain perception, individual differences in the functions of the RVM in response to opioids have not been elucidated. Pain-related behavior among inbred mouse strains may reflect individual differences in sensitivity to pain. We therefore investigated the changes in action potentials of RVM neurons in response to opioid in different ...
5 CitationsSource
32 Citations
#1Atsuhiro Sakamoto (Nippon Medical School)H-Index: 25
#2Masafumi KitakazeH-Index: 66
Last.Saichi HosodaH-Index: 31
view all 6 authors...
Background: Recent studies have suggested that esmolol is the first choice for rate control in patients with postoperative atrial fibrillation (AF) after coronary artery bypass surgery, but side-effects of esmolol such as hypotension are problematic. To overcome this problem, landiolol, an ultra-short-acting β1-blocker with a less negative inotropic effect than esmolol, has been developed. The aim of the present study was to investigate whether landiolol was effective for both rate control and c...
38 CitationsSource
#1Tomohiro Kiya (Sapporo Medical University)H-Index: 3
#2Tomoyuki Kawamata (Sapporo Medical University)H-Index: 25
Last.Michiaki Yamakage (Sapporo Medical University)H-Index: 25
view all 4 authors...
Abstract Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the in...
21 CitationsSource
POPS研究会は,術後患者のQOLを高める術後疼痛管理サービス(Post Operative Pain Service:POPS)を標準化することを目的として活動している.その一環として,術後疼痛管理の全国アンケート調査を行ったので,一部を報告する.わが国における腹部手術の術後疼痛管理は,ディスポーザブルPCA注入器を用い,持続投与0.2%ロピバカイン4ml/h・PCA 3ml/回(充填時間30~60分)・フェンタニル0.3mg/日を2.5~3日間行う硬膜外PCAか,フェンタニル持続投与25μg/h・PCA 25μg/回(充填時間10分)を2~2.5日間行うIV-PCAが平均的であることがわかった.