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Jae Cheol Lee
Sungkyunkwan University
CancerPathologyLung cancerCancer researchMedicine
121Publications
23H-index
1,687Citations
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Publications 126
Newest
#1Sang Ah Yi (SKKU: Sungkyunkwan University)H-Index: 5
#2Dong Hoon Lee (Yonsei University)H-Index: 7
Last. 이지은 ( Ji Eun Lee ) (SKKU: Sungkyunkwan University)H-Index: 13
view all 18 authors...
E6 oncoprotein derived from high-risk human papillomavirus (HPV) drives the development of cervical cancer through p53 degradation. Because cervical cancer therapies to inactivate HPV or E6 protein are not available, alternative strategies are required. Here, we show that HPV-mediated nuclear export of human heterochromatin protein 1γ (HP1γ) reduces the stability of p53 through UBE2L3-mediated p53 polyubiquitination during cervical cancer progression. In general, HP1 plays a key role in heteroch...
Source
#1Kyung-Tae Kim (SKKU: Sungkyunkwan University)H-Index: 4
Last. Jae Cheol LeeH-Index: 23
view all 6 authors...
Ginsenoside Rg3, one of the major components in Panax ginseng, has been reported to possess several therapeutic effects including anti-obesity properties. However, its effect on the browning of mature white adipocytes as well as the underlying mechanism remains poorly understood. In this study, we suggested a novel role of Rg3 in the browning of mature 3T3-L1 adipocytes by upregulating browning-related gene expression. The browning effects of Rg3 on differentiated 3T3-L1 adipocytes were evaluate...
1 CitationsSource
#1Seoung Rak Lee (SKKU: Sungkyunkwan University)H-Index: 9
#2Sang Ah Yi (SKKU: Sungkyunkwan University)H-Index: 5
Last. Yang Soo Kim (SKKU: Sungkyunkwan University)H-Index: 99
view all 7 authors...
Abstract Two-spotted cricket Gryllus bimaculatus is one of many cricket species, and it is widely used as a food source for insectivorous animals. Moreover, this species is one of the edible insects approved by the Korea Food and Drug Administration (KFDA). (±)-Kituramides A (1) and B (2), which are pairs of novel enantiomeric dopamine dimers possessing a formamide group, were isolated from the two-spotted cricket, together with four other known biosynthetically related compounds (3–6). The chem...
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#1Sang Ah YiH-Index: 5
#2Ki Hong NamH-Index: 3
Last. Jae Cheol LeeH-Index: 23
view all 8 authors...
Vulpinic acid, a naturally occurring methyl ester of pulvinic acid, has been reported to exert anti-fungal, anti-cancer, and anti-oxidative effects. However, its metabolic action has not been implicated yet. Here, we show that vulpinic acid derived from a mushroom, Pulveroboletus ravenelii controls the cell fate of mesenchymal stem cells and preadipocytes by inducing the acetylation of histone H3 and α-tubulin, respectively. The treatment of 10T1/2 mesenchymal stem cells with vulpinic acid incre...
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#1Su Cheol BaekH-Index: 1
#2Ki Hong NamH-Index: 3
Last. Yang Soo KimH-Index: 99
view all 8 authors...
Garlic (Allium sativum L.) is utilized worldwide for culinary and medicinal use and has diverse health benefits. As part of our ongoing research to identify bioactive components from natural resources, phytochemical analysis of the methanolic extract of garlic led to the isolation and characterization of six compounds: Three eugenol diglycosides (1–3) and three β-carboline alkaloids (4–6). In particular, the absolute configurations of β-carboline alkaloids (5 and 6) were established by gauge-inc...
1 CitationsSource
#1Haodi Wu (Stanford University)H-Index: 20
#2Huaxiao Yang (Stanford University)H-Index: 10
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 13 authors...
5 CitationsSource
#1Seoung Rak Lee (SKKU: Sungkyunkwan University)H-Index: 9
#2Sang Ah Yi (SKKU: Sungkyunkwan University)H-Index: 5
Last. Yang Soo Kim (SKKU: Sungkyunkwan University)H-Index: 99
view all 6 authors...
Amanita pantherina is a poisonous mushroom that causes muscle cramps, insanity, and audiovisual disorders. As part of our systematic study on Korean mushrooms, a chemical investigation of A. pantherina fruiting bodies resulted in the isolation and structural identification of three new fatty acid derivatives, pantheric acids A–C (1–3), and a known compound, 1,10-dimethyl ester-2-decenedioic acid (4). Although 1,10-dimethyl ester-2-decenedioic acid (4) was previously reported as a synthetic produ...
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#1Ki Hong Nam (SKKU: Sungkyunkwan University)H-Index: 3
#2Sang Ah Yi (SKKU: Sungkyunkwan University)H-Index: 5
Last. Jeung-Whan Han (SKKU: Sungkyunkwan University)H-Index: 27
view all 13 authors...
The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a synergistic anti-tumor effect with conventional chemotherapy agents. In this study, we identified a novel S6K1 inhibitor, rosmarinic acid methyl ester (RAME) for the use of therapeutic agent against cervical cancer. Combined structure- and ligand-based virtual screening was employed to iden...
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#1Tomoya Kitani (Stanford University)H-Index: 4
#2Sang-Ging Ong (UIC: University of Illinois at Chicago)H-Index: 2
Last. Joseph C. Wu (Stanford University)H-Index: 91
view all 14 authors...
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#1Jae Cheol LeeH-Index: 23
#2Vittavat Termglinchan (Cardiovascular Institute of the South)H-Index: 9
Last. Joseph C. Wu (Cardiovascular Institute of the South)H-Index: 91
view all 24 authors...
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we modelled the LMNA-related DCM in vitro using patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Electrophysiological studies showed that the mutant iPSC-CMs displayed aberrant calcium homeostasis that led to arrhyt...
5 CitationsSource
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