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Jaecheol Lee
Stanford University
21Publications
10H-index
312Citations
Publications 21
Newest
#1Ki Hong Nam (SKKU: Sungkyunkwan University)H-Index: 3
#2Sang Ah Yi (SKKU: Sungkyunkwan University)H-Index: 6
Last.Kang Ro Lee (SKKU: Sungkyunkwan University)H-Index: 30
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The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a synergistic anti-tumor effect with conventional chemotherapy agents. In this study, we identified a novel S6K1 inhibitor, rosmarinic acid methyl ester (RAME) for the use of therapeutic agent against cervical cancer. Combined structure- and ligand-based virtual screening was employed to iden...
#1Tomoya Kitani (Stanford University)H-Index: 3
#2Sang-Ging Ong (UIC: University of Illinois at Chicago)H-Index: 1
Last.Melinda L. Telli (Stanford University)H-Index: 25
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#1Jaecheol LeeH-Index: 10
#2Vittavat Termglinchan (Cardiovascular Institute of the South)H-Index: 9
Last.Haodi Wu (Cardiovascular Institute of the South)H-Index: 18
view all 24 authors...
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we modelled the LMNA-related DCM in vitro using patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Electrophysiological studies showed that the mutant iPSC-CMs displayed aberrant calcium homeostasis that led to arrhyt...
#1Tomoya Kitani (Cardiovascular Institute of the South)H-Index: 3
#2Sang-Ging Ong (UIC: University of Illinois at Chicago)H-Index: 1
Last.Jaecheol Lee (SKKU: Sungkyunkwan University)H-Index: 10
view all 14 authors...
Background: Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their us...
#1Timon Seeger (Stanford University)H-Index: 10
#2Rajani Shrestha (Stanford University)H-Index: 3
Last.Matthew Greenhaw (Stanford University)H-Index: 1
view all 19 authors...
Background: Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in myosin-binding protein C3 (MYBPC3) resulting in a premature termination codon (PTC). The underlying mechanisms of ...
#1Jared M. ChurkoH-Index: 23
#2Priyanka Garg (Cardiovascular Institute of the South)H-Index: 5
Last.Kashish Chetal (Cincinnati Children's Hospital Medical Center)H-Index: 4
view all 17 authors...
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a powerful tool for human disease modeling and therapeutic testing. However, their use remains limited by their immaturity and heterogeneity. To characterize the source of this heterogeneity, we applied complementary single-cell RNA-seq and bulk RNA-seq technologies over time during hiPSC cardiac differentiation and in the adult heart. Using integrated transcriptomic and splicing analysis, more than half a dozen d...
#1Ki Hong Nam (SKKU: Sungkyunkwan University)H-Index: 3
#2Sang Ah Yi (SKKU: Sungkyunkwan University)H-Index: 6
Last.Jeung-Whan Han (SKKU: Sungkyunkwan University)H-Index: 27
view all 9 authors...
Abstract Eudesmin has been reported to possess diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities. However, its molecular action has not been implicated in metabolic disease. In this study, we show that treatment of mesenchymal stem cells (MSCs) with eudesmin disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibited activation and nuclear translocation of S6K1. Consequently, S6K1-mediated phosphorylation of H2B ...
#1Hyun Jung KooH-Index: 10
#2Mi-Young KimH-Index: 38
Last.Chang-Min ChoiH-Index: 13
view all 9 authors...
CT characteristics such as peripheral tumor location with vascular convergence, the presence of a pleural tag, and air bronchogram of lung lesions, at the time of rebiopsy, were significantly associated with positivity for the T790M mutation in patients with non–small cell lung cancer after first-line epidermal growth factor receptor–tyrosine kinase inhibitor therapy failure.
#1David T. Paik (Stanford University)H-Index: 6
#2Lei Tian (Stanford University)H-Index: 2
Last.Jan Willem Buikema (UU: Utrecht University)H-Index: 6
view all 14 authors...
Rationale: Human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) have risen as a useful tool in cardiovascular research, offering a wide gamut of translational and clinical applications. However, inefficiency of the currently available iPSC-EC differentiation protocol and underlying heterogeneity of derived iPSC-ECs remain as major limitations of iPSC-EC technology. Objective: Here we performed droplet-based single-cell RNA-sequencing (scRNA-seq) of the human iPSCs following i...
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