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Agata Hanna Bryk
Jagiellonian University Medical College
EndocrinologyCardiologyType 2 diabetesDiabetes mellitusMedicine
16Publications
3H-index
41Citations
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Publications 15
Newest
Abstract Background The post-translational protein modification via lysine residues can significantly alter its function. α2-antiplasmin, a key inhibitor of fibrinolysis, contains 19 lysine residues. Aim We sought to identify sites of glycation and acetylation in human α2-antiplasmin and test whether the competition might occur on the lysine residues of α2-antiplasmin. Methods We analyzed human α2-antiplasmin (1) untreated; (2) incubated with increasing concentrations of β- d -glucose (0, 5, 10,...
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#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 7 authors...
Abstract Background Type 2 diabetes mellitus (T2DM) is associated with hypofibrinolysis and increased factor XIII-mediated α2-antiplasmin incorporation into the fibrin clot. It is unclear whether there are sex-related differences in α2-antiplasmin incorporation in relation to impaired clot lysis in T2DM. Aim We investigated α2-antiplasmin incorporation into fibrin clots as a determinant of clot lysability in patients of both sexes with T2DM. Methods In a group of 113 T2DM patients, 54 (47.8%) of...
1 CitationsSource
#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Shannon M. Prior (UVM: University of Vermont)H-Index: 3
Last. Anetta Undas (Jan Kochanowski University)H-Index: 41
view all 8 authors...
Background Type 2 diabetes mellitus (T2DM) is associated with a hypercoagulable state and increased neutrophil extracellular traps formation (NETosis). We investigated predictors of NETosis and cell death markers in circulating blood and their association with a prothrombotic state in T2DM.
1 CitationsSource
#1Agnieszka Janion-Sadowska (Jan Kochanowski University)H-Index: 6
#2Marcin Sadowski (Jan Kochanowski University)H-Index: 9
Last. Anetta UndasH-Index: 41
view all 14 authors...
Background: The Jessa AF Knowledge Questionnaire (JAKQ) was successfully used to assess knowledge gaps in patients with atrial fibrillation (AF) . Aim: To evaluate regional differences in the patient awareness considering AF diagnosis and oral anticoagulation use in Poland. Methods: A total of 1583 patients with AF at a median age of 72 (IQR 66-79) years completed the JAKQ in three cardiology centres (centre I Krakow, centre II Torun, centre III Kielce) from January 2017 to June 2018. The final ...
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#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Konieczyńska MH-Index: 5
Last. Anetta Undas (Jan Kochanowski University)H-Index: 41
view all 7 authors...
Objective We investigated clinical and laboratory determinants of plasma protein oxidation and its associations with clot fibrinolysis in type 2 diabetes patients. Materials and Methods Our cross-sectional study consisted of 246 type 2 diabetic patients, 143 (58%) with concomitant cardiovascular disease (CVD), including 41 (17%) with previous myocardial infarction (MI). We measured total protein carbonylation (PC), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (T...
2 CitationsSource
#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Piotr Mazur (Jagiellonian University Medical College)H-Index: 6
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 8 authors...
1 CitationsSource
#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Konieczyńska MH-Index: 5
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 4 authors...
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#1Konieczyńska MH-Index: 5
#2Ewa Sobieraj (Jagiellonian University Medical College)H-Index: 1
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 11 authors...
Background: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used for stroke prevention in patients with atrial fibrillation (AF) worldwide. Few articles have compared current understanding of AF patients about the disease and anticoagulant therapy in relation to the medications used. Aim: We sought to compare the knowledge of AF and anticoagulation between AF patients treated with NOACs and those on vitamin K antagonists (VKAs). Methods: We used the Jessa AF Knowledge Quest...
3 CitationsSource
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#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Krzysztof PlensH-Index: 4
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 3 authors...
Background: The SAMe-TT2R2 (sex female, age, medical history, treatment, tobacco use, race) score was developed in patients with atrial fibrillation (AF) on warfarin. The present study aimed to 1) compare the anticoagulation quality and management of AF patients treated with warfarin with those on acenocoumarol and 2) optimize the SAMe-TT2R2 score to detect AF patients at high risk of unstable anticoagulation with acenocoumarol and warfarin. Methods: In a single-center retrospective study, 320 p...
2 CitationsSource
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