Loïc Guillevin
Paris Descartes University
PathologyImmunologyVasculitisDiabetes mellitusMedicine
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Publications 1062
Reduction in cyclophosphamide cumulative dose and introduction of newer immunosuppressive drugs may reduce the malignant burden of systemic necrotising vasculitis (SNV).1 2 This study aimed to describe malignancies recorded in five randomised controlled trials in SNV conducted by the French Vasculitis Study Group and to identify predictive factors. CHUSPAN, CHUSPAN 2, WEGENT, CORTAGE and MAINRITSAN trials evaluated different therapeutic strategies, summarised in online supplementary table S1, fo...
#2B. Dunogué (Paris V: Paris Descartes University)H-Index: 12
Last. Christian Roux (Paris V: Paris Descartes University)H-Index: 75
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#1Benjamin ChaigneH-Index: 4
#1B. Chaigne (French Institute of Health and Medical Research)H-Index: 1
Last. Luc Mouthon (CNRS: Centre national de la recherche scientifique)H-Index: 34
view all 12 authors...
Abstract Introduction Little is known about systemic sclerosis (SSc)-associated myopathy (SScAM) treatment. Herein we evaluated the use of intravenous immunoglobulin (IVIg) in SScAM. Methods We conducted a retrospective study of patients with SScAM in the Internal medicine department of Cochin University Hospital between 1993 and 2017. Results Fifty-two patients were included comprising 18 (34.6%) with limited SSc and 34 (65.4%) with diffuse SSc. SScAM occurred at a median [interquartile range (...
Abstract Background Progressive fibrosing interstitial lung disease (ILD) is rarely associated with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). This study focused on the outcomes of ILD patients with associated AAV (AAV–ILD). Methods AAV–ILD (cases: microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) with ILD) were compared to AAV patients without ILD (controls). ILD was defined as a usual interstitial pneumonia (UIP) or non-specific interstitial pn...
#1Yann Nguyen (Paris V: Paris Descartes University)H-Index: 1
#2Loïc Guillevin (Paris V: Paris Descartes University)H-Index: 94
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg–Strauss syndrome, a systemic necrotizing vasculitis of small- and medium-sized vessels, is characterized by asthma and blood eosinophilia, and anti-myeloperoxidase (MPO) anti-neutrophil cytoplasm antibodies (ANCA) in one-third of the patients. Its pathophysiology is complex, with several mechanisms being involved. EGPA typically occurs in previously asthmatic patients, and involves the skin, lungs, and peripheral nerves....
#1Raphael LhoteH-Index: 2
#2Marie Chilles (University of Paris)
Last. Colas TcherakianH-Index: 11
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Objective To report on a large series of patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) and bronchiectasis, with a specific focus on the timeline of occurrence of both features. Methods Retrospective nationwide multicentric study of patients diagnosed with both AAV and bronchiectasis. Results Sixty-one patients were included among which 27 (44.25 %) had microscopic polyangiitis (MPA), 27 (44.25%) had granulomatosis with polyangiitis and 7 (11.5%) had eosin...
#2Adrien Joseph (French Institute of Health and Medical Research)
Last. B. Terrier (Paris V: Paris Descartes University)H-Index: 3
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#1Paul A. LyonsH-Index: 42
#2James E. PetersH-Index: 8
Last. Kenneth G. C. SmithH-Index: 66
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#1Loïc Guillevin (Paris V: Paris Descartes University)H-Index: 94
#2Arnaud HotH-Index: 11
Last. Benjamin Terrier (Paris V: Paris Descartes University)H-Index: 38
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