David F. Meaney
University of Pennsylvania
NeuroscienceDiffuse axonal injuryTraumatic brain injuryMedicineBiology
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Publications 155
#1Kryshawna Beard (UPenn: University of Pennsylvania)H-Index: 1
#2David F. Meaney (UPenn: University of Pennsylvania)H-Index: 53
Last. David Issadore (UPenn: University of Pennsylvania)H-Index: 23
view all 3 authors...
Extracellular vesicles (EVs) have emerged as key mediators of cell-cell communication during homeostasis and in pathology. Central Nervous System (CNS)-derived EVs contain cell type-specific surface markers and intralumenal protein, RNA, DNA, and metabolite cargo that can be used to assess the biochemical and molecular state of neurons and glia during neurological injury and disease. The development of EV isolation strategies coupled with analysis of multiplexed biomarker and clinical data has t...
#1Erin D. Anderson (UPenn: University of Pennsylvania)
#2J. Sebastian Giudice (UVA: University of Virginia)H-Index: 2
Last. David F. Meaney (UPenn: University of Pennsylvania)H-Index: 53
view all 5 authors...
Concussion is a significant public health problem affecting 1.6 to 2.4 million Americans annually. An alternative to reducing the burden of concussion is to reduce its incidence with improved protective equipment and injury mitigation systems. Finite element (FE) models of the brain response to blunt trauma are often used to estimate injury potential and can lead to improved helmet designs. However, these models have yet to incorporate how the patterns of brain connectivity disruption after impa...
#1David Gabrieli (UPenn: University of Pennsylvania)H-Index: 5
#2Nicholas Vigilante (UPenn: University of Pennsylvania)
Last. David F. Meaney (UPenn: University of Pennsylvania)H-Index: 53
view all 9 authors...
With an increasing focus on long-term consequences of concussive brain injuries, there is a new emphasis on developing tools that can accurately predict the mechanical response of the brain to impact loading. Although finite element models estimate the brain response under dynamic loading, these models are not capable of delivering rapid (~seconds) estimates of the brain's mechanical response. In this study, we develop a multibody spring-mass-damper model that estimates the regional motion of th...
#1Edward Vogel (Columbia University)H-Index: 4
#2Matthew B. Panzer (UVA: University of Virginia)H-Index: 6
Last. Barclay Morrison (Columbia University)H-Index: 35
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The Veterans Health Administration determined that over 250,000 U.S. service members were diagnosed with a traumatic brain injury (TBI) between 2008 and 2018, of which a great proportion were due to blast exposure. Although the penetrating (secondary) and inertia-driven (tertiary) phases of blast-induced TBI (bTBI) have been studied thoroughly and are known to be injurious, primary blast brain injury has been less studied. We investigated the biomechanics of primary bTBI in our previously develo...
Synchronization of neural activity across brain regions is critical to processes that include perception, learning, and memory. After traumatic brain injury (TBI), neuronal degeneration is one possible effect and can alter communication between neural circuits. Consequently, synchronization between neurons may change and can contribute to both lasting changes in functional brain networks and cognitive impairment in patients. However, fundamental principles relating exactly how TBI at the cellula...
#1Anton Omelchenko (RU: Rutgers University)H-Index: 1
#2Anil B. Shrirao (RU: Rutgers University)H-Index: 5
Last. Bonnie L. Firestein (RU: Rutgers University)H-Index: 34
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Mild traumatic brain injury (mTBI) is a frequently overlooked public health concern that is difficult to diagnose and treat. Diffuse axonal injury (DAI) is a common mTBI neuropathology in which axonal shearing and stretching induces breakdown of the cytoskeleton, impaired axonal trafficking, axonal degeneration, and cognitive dysfunction. DAI is becoming recognized as a principal neuropathology of mTBI with supporting evidence from animal model, human pathology, and neuroimaging studies. As mito...
1 CitationsSource
#1V PatelMihir (RU: Rutgers University)
#2SewellEmily (UPenn: University of Pennsylvania)
Last. L FiresteinBonnie (RU: Rutgers University)
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Abstract Postsynaptic density 95 (PSD-95), the major scaffold protein at excitatory synapses, plays a major role in mediating intracellular signaling by synaptic N-methyl-d-aspartate (NMDA) type gl...
#1David Gabrieli (UPenn: University of Pennsylvania)H-Index: 5
#2Samantha N. Schumm (UPenn: University of Pennsylvania)H-Index: 1
Last. David F. Meaney (UPenn: University of Pennsylvania)H-Index: 53
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Abstract Traumatic brain injury (TBI) can lead to neurodegeneration in the injured circuitry, either through primary structural damage to the neuron or secondary effects that disrupt key cellular processes. Moreover, traumatic injuries can preferentially impact subpopulations of neurons, but the functional network effects of these targeted degeneration profiles remain unclear. Although isolating the consequences of complex injury dynamics and long-term recovery of the circuit can be difficult to...
1 CitationsSource
#1KoJina (UPenn: University of Pennsylvania)
#2HemphillMatthew (UPenn: University of Pennsylvania)
Last. IssadoreDavid (UPenn: University of Pennsylvania)
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Abstract The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in the type and severity of injuries and the multiple endophenotypes that describe each patient's ...
3 CitationsSource
#1Michelle C. LaPlaca (Georgia Institute of Technology)H-Index: 35
#2M. Christian Lessing (Georgia Institute of Technology)H-Index: 2
Last. Liying Zhang (WSU: Wayne State University)H-Index: 35
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Abstract Background An increases in plasma membrane permeability is part of the acute pathology of traumatic brain injury and may be a function of excessive membrane force. This membrane damage, or mechanoporation, allows non-specific flux of ions and other molecules across the plasma membrane, and may ultimately lead to cell death. The relationships among tissue stress and strain, membrane permeability, and subsequent cell degeneration, however, are not fully understood. Methods Fluorescent mol...
6 CitationsSource