Ihab Ansari
Hebrew University of Jerusalem
CancerTranscriptomeDNA methylationEpigeneticsColorectal cancer
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Publications 2
#1Ihab Ansari (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Günter Raddatz (DKFZ: German Cancer Research Center)H-Index: 11
Last. Eran Elinav (Weizmann Institute of Science)H-Index: 56
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Although much research has been done on the diversity of the gut microbiome, little is known about how it influences intestinal homeostasis under normal and pathogenic conditions. Epigenetic mechanisms have recently been suggested to operate at the interface between the microbiota and the intestinal epithelium. We performed whole-genome bisulfite sequencing on conventionally raised and germ-free mice, and discovered that exposure to commensal microbiota induced localized DNA methylation changes ...
6 CitationsSource
#1Monther Abu-Remaileh (HUJI: Hebrew University of Jerusalem)H-Index: 14
#2Sebastian Bender (DKFZ: German Cancer Research Center)H-Index: 23
Last. Frank LykoH-Index: 52
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Chronic inflammation represents a major risk factor for tumor formation, but the underlying mechanisms have remained largely unknown. Epigenetic mechanisms can record the effects of environmental challenges on the genome level and could therefore play an important role in the pathogenesis of inflammation-associated tumors. Using single-base methylation maps and transcriptome analyses of a colitis-induced mouse colon cancer model, we identified a novel epigenetic program that is characterized by ...
42 CitationsSource