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Jun Zhang
Southern Medical University
Molecular biologyEndoplasmic reticulumCancer researchEpithelial–mesenchymal transitionBiology
23Publications
5H-index
98Citations
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Publications 18
Newest
#1Minhui Li (Southern Medical University)H-Index: 1
#2Tingting JiangH-Index: 2
Last. Jun Zhang (Southern Medical University)H-Index: 5
view all 7 authors...
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#1Ying Li (Southern Medical University)H-Index: 2
#2Jun Zhang (Southern Medical University)H-Index: 5
Last. Zhe Wang (Southern Medical University)
view all 11 authors...
Polycystic ovary syndrome (PCOS) causes anovulatory infertility in women of reproductive age, but etiopathogenesis of PCOS remains undetermined. Taurine up-regulated 1 (TUG1), an evolutionarily con...
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#1Xing-Yu Zhou (Southern Medical University)H-Index: 5
#2Ying Li (Southern Medical University)H-Index: 2
Last. Shi-Ling Chen (Southern Medical University)H-Index: 14
view all 9 authors...
Aim: To identify the expression profiles and potential functions of circular RNAs (circRNAs) in granulosa cells (GCs) from women with biochemical premature ovarian insufficiency (bPOI). Patients & methods: CircRNAs microarray analysis was performed to GCs from 8 patients with bPOI and 8 control women, followed by qRT-PCR in 15 paired samples. CircRNA-miRNA networks and the prediction of their enriched signaling pathways were conducted by bioinformatics analysis. Results: A total of 133 upregulat...
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#1Jing Zhe (Southern Medical University)H-Index: 2
#2De-Sheng Ye (Southern Medical University)H-Index: 7
Last. Shi-Ling Chen (Southern Medical University)H-Index: 14
view all 8 authors...
Premature ovarian insufficiency (POI) is a highly heterogeneous ovarian disorder. Genetic factors account for the cause of POI. We aimed to analyze the genetic alterations in two affected sisters diagnosed with POI and their parents from a highly consanguineous Chinese Han family. Whole-exome sequencing was performed, and bioinformatics analysis was used to determine the potential genetic cause of POI in this family. A SYCE1 deletion was verified by Sanger sequencing. A homozygous deletion in SY...
1 CitationsSource
#1Ying Li (Southern Medical University)H-Index: 2
#2Yu-Dong Liu (Southern Medical University)H-Index: 6
Last. Ying-Xue Chen (Southern Medical University)H-Index: 1
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Abstract Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in reproductive-aged women; however, its etiology remains poorly understood. This study aimed to reveal the role of miR-29a in PCOS. MiR-29a levels were measured in the granulosa cells (GCs) of forty-seven PCOS patients and forty-seven controls. A receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of miR-29a in non-hyperandrogenism PCOS. MiR-29a was overexpressed in...
3 CitationsSource
#1Jun Zhang (Southern Medical University)H-Index: 5
Last. Shi-Ling Chen (Southern Medical University)H-Index: 14
view all 8 authors...
OBJECTIVE: To compare the effects of cetrorelix and ganirelix in gonadotropin-releasing hormone antagonist (GnRH-ant) cycles for preventing premature luteinizing hormone (LH) surges and on clinical outcomes of IVF-ET cycles. METHODS: We retrospectively analyzed 2572 GnRH-ant cycles of in vitro fertilization and embryo transfer from January, 2013 to December, 2016, including 1368 cycles with cetrorelix treatment and 1204 cycles with ganirelix treatment. The baseline characteristics of the patient...
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#1Jun Zhang (Southern Medical University)H-Index: 5
#2Tingting Jiang (Southern Medical University)H-Index: 2
Last. Xun Tang (Southern Medical University)H-Index: 5
view all 10 authors...
Epithelial-to-mesenchymal transition (EMT) and injury of tubular cells play critical roles in the pathogenesis of diabetic nephropathy (DN). lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to be involved in DN progression. However, whether MALAT1 induces EMT and injury in tubular cells is unclear. Here, we investigated the effects of MALAT1 on human proximal tubular cells (HK-2 cells) and the underlying mechanism. We performed qPCR to detect MALAT1, E-cadher...
4 CitationsSource
#1Jing Zhe (Southern Medical University)H-Index: 2
Last. Xiaomin Wu (Southern Medical University)
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OBJECTIVE: To explore the causes of oocyte vitrification and its application in assisted reproduction. METHODS: We retrospectively analyzed the data of 26 patients with 27 cycles of oocyte vitrification cryopreservation undergoing intracytoplasmic sperm injection (ICSI) and embryo transfer between January, 2008 and October, 2018. The causes of oocyte vitrification and the outcomes of ICSI and clinical pregnancy were analyzed. RESULTS: The causes of oocytes vitrification included mainly azoosperm...
Source
#1Jing Zhe (Southern Medical University)H-Index: 2
#2Shi-Ling Chen (Southern Medical University)H-Index: 14
Last. Jun Zhang (Southern Medical University)H-Index: 1
view all 7 authors...
Background Premature ovarian insufficiency (POI) leads to early loss of ovarian function in women aged < 40 years and is highly heterogeneous in etiology. The genetic etiology of this disorder remains unknown in most women with POI.
2 CitationsSource
#1Jin Xiang (Southern Medical University)H-Index: 1
#2Tingting JiangH-Index: 2
Last. Jun Zhang (Southern Medical University)H-Index: 5
view all 6 authors...
Abstract Recent studies have shown that autophagy exhibits a protective role in acute kidney injury (AKI), and the accumulation of advanced oxidation protein products (AOPP) participates in the progression of kidney diseases. Our previous study indicated that AOPP induced injury in renal tubular epithelial cells (RTECs) through autophagy inhibition. Besides, we found that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) enhanced autophagy in AOPP-treated RTECs, but the underlying m...
5 CitationsSource
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