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Jun Zhang
Southern Medical University
13Publications
5H-index
66Citations
Publications 13
Newest
#1Jun Zhang (Southern Medical University)H-Index: 5
#2Tingting Jiang (Southern Medical University)H-Index: 1
Last.Xun Tang (Southern Medical University)H-Index: 4
view all 10 authors...
Epithelial-to-mesenchymal transition (EMT) and injury of tubular cells play critical roles in the pathogenesis of diabetic nephropathy (DN). lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to be involved in DN progression. However, whether MALAT1 induces EMT and injury in tubular cells is unclear. Here, we investigated the effects of MALAT1 on human proximal tubular cells (HK-2 cells) and the underlying mechanism. We performed qPCR to detect MALAT1, E-cadher...
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#1Jin Xiang (Southern Medical University)H-Index: 1
#2Tingting JiangH-Index: 1
Last.Jun Zhang (Southern Medical University)H-Index: 5
view all 6 authors...
Abstract Recent studies have shown that autophagy exhibits a protective role in acute kidney injury (AKI), and the accumulation of advanced oxidation protein products (AOPP) participates in the progression of kidney diseases. Our previous study indicated that AOPP induced injury in renal tubular epithelial cells (RTECs) through autophagy inhibition. Besides, we found that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) enhanced autophagy in AOPP-treated RTECs, but the underlying m...
1 CitationsSource
#1Jun Zhang (Southern Medical University)H-Index: 5
#2Xiaohong Xiang (Southern Medical University)H-Index: 1
Last.Xun Tang (Southern Medical University)H-Index: 4
view all 10 authors...
1 CitationsSource
#1Xiujie Liang (Southern Medical University)H-Index: 4
#2Na Duan (Southern Medical University)H-Index: 3
Last.Jun Zhang (Southern Medical University)H-Index: 5
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Abstract Endothelial-to-mesenchymal transition (EndMT) in renal glomerular endothelial cells plays a critical role in the pathogenesis of diabetic nephropathy (DN). Furthermore, advanced oxidation protein products (AOPPs) have been shown to contribute to the progression of DN. However, whether AOPPs induce EndMT in renal glomerular endothelial cells remains unclear. Thus, we investigated the effect of AOPPs on human renal glomerular endothelial cells (HRGECs) and the mechanisms underlying the ef...
9 CitationsSource
#1Guang Rong (Southern Medical University)H-Index: 3
#2Xun Tang (Southern Medical University)H-Index: 4
Last.Xiujie Liang (Southern Medical University)H-Index: 4
view all 8 authors...
Although podocyte apoptosis has been shown to be induced by the accumulation of advanced oxidation protein products (AOPPs), the mechanisms through which AOPPs trigger apoptosis in these cells remain unclear. In this study, we investigated the role of endoplasmic reticulum (ER) stress in AOPP-induced podocyte apoptosis. AOPP treatment induced overexpression of glucose-regulated protein 78 and CCAAT/enhancer-binding protein-homologous protein (CHOP) in podocytes, indicating that AOPPs induced ER ...
15 CitationsSource
#1Xun Tang (Southern Medical University)H-Index: 4
#2Xiujie Liang (Southern Medical University)H-Index: 4
Last.Jun Zhang (Southern Medical University)H-Index: 5
view all 10 authors...
Advanced oxidation protein products (AOPPs) accelerate the progression of chronic kidney disease. We previously demonstrated that AOPPs induce hypertrophy and epithelial-to-mesenchymal transition (EMT) in human proximal tubular cells (HK-2 cells) through induction of endoplasmic reticulum (ER) stress. However, which pathway of unfolded protein response (UPR) induced by ER stress plays crucial roles in this process remains unclear. In this study, we investigated the roles of the protein kinase RN...
9 CitationsSource
#1Xun TangH-Index: 4
#2Guang RongH-Index: 3
Last.Xiujie LiangH-Index: 4
view all 7 authors...
Background: In chronic kidney disease (CKD), the accumulation of advanced oxidation protein products (AOPPs) is prevalent. Hypertrophy and epithelial-to-mesenchymal transition (EMT) of tubular cells are associated with the pathogenesis of CKD. However, whether AOPPs induce tubular-cell hypertrophy and EMT is unclear. In this study, we investigated the effect of AOPPs on human proximal tubular cells (HK-2 cells) and the mechanisms underlying tubular-cell hypertrophy and EMT in vitro. Methods: The...
16 CitationsSource
#1Jun Zhang (Southern Medical University)H-Index: 5
#2Qiu MH-Index: 2
Last.Tang XH-Index: 2
view all 6 authors...
Objective To investigate the effects of advanced oxidation protein products(AOPP) on epithelial-to-mesenchymal transition(EMT) in cultured human proximal tubular epithelial cells(HK-2) and explore the mechanism.Methods HK-2 cells treated with 50,100,200,and 400 μg/ml AOPP or 50 μg/m bovine serum albumin(BSA) for 24 h,or with 200 μg/ml AOPP for 0.5,1,3,6,12,and 24 h were examined for the protein expression of α- SMA and E- cadherin.In cells pretreated with diphenyleneiodonium(DPI) or cytoplasmic ...
4 Citations
#1Jun Zhang (Southern Medical University)H-Index: 5
#2Liu CH-Index: 1
Objective To introduce a training model for laparoscopic dismembered pyeloplasty. Methods The model of ureteropelvic junction obstruction was simulated using pig kidney and chicken crop. With the model placed in a training box,8 residents without laparoscopic experience but with basic technical training performed 10 rounds of anastomosis according to the standard operation procedures. For each resident, the operating time and quality of the operation were recorded and assessed. Results All the 8...
1 Citations
#1Jun Zhang (Southern Medical University)H-Index: 5
#2Guo TtH-Index: 1
Last.Tang XH-Index: 1
view all 7 authors...
Objective To study the effect of arctiin on mouse podocyte epithelial-mesenchymal transition(EMT) induced by advanced oxidation protein products(AOPP).Methods Mouse podocytes were stimulated by 200 μg/ml AOPP for 24 h in the presence of 50,100,200,and 400 μmol/L arctiin.The expressions of α-smooth muscle actin,Grp78 and CHOP were detected using Western blotting.Result The expressions of α-SMA,Grp78 and CHOP were inhibited by arctiin,showing a dose-dependent effect within a given range of arctiin...
5 Citations
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