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Vladimir Ilyukha
Petrozavodsk State University
8Publications
5H-index
105Citations
Publications 9
Newest
#1Hayley I. Muendlein (Tufts University)H-Index: 3
#2Joseph Sarhan (Tufts University)H-Index: 3
Last.Soroush Tahmasebi (McGill University)H-Index: 8
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Summary Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activation of MAPK signaling. However, the regulatory mechanisms underlying this kinase-dependent cytokine production remain poorly understood. In the present study, we establish that the kinase activity of RIPK1/3 regulates cytokine translation in mouse an...
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#1Joseph Sarhan (Tufts University)H-Index: 3
#2Beiyun C. Liu (Tufts University)H-Index: 6
Last.Alexander PoltorakH-Index: 18
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Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as a driver of necroptosis, a necrotic form of cell death downstream of receptor-interacting protein (RIP) kinase activation and executed by mixed lineage kinase like-domain (MLKL) protein. We found tha...
15 CitationsSource
#1Beiyun C. Liu (Tufts University)H-Index: 6
#2Joseph Sarhan (Tufts University)H-Index: 3
Last.Alexander Poltorak (Tufts University)H-Index: 18
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Summary Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture and bacteriolysis preceding caspase-11 activation. We show here that macrophage death occurred independently of microbial-induced IFN signaling and that GBPs are dispensable for pathogen vacuole rupture. Instead, the host-intrinsic IFN status sustained ...
19 CitationsSource
#1Bridget Larkin (Tufts University)H-Index: 5
#2Vladimir Ilyukha (PetrSU: Petrozavodsk State University)H-Index: 5
Last.Alexander Poltorak (Tufts University)H-Index: 18
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Stimulator of interferon genes (STING) was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. In this study, to our knowledge we provide the first evidence of STING activation in T cells, in which STING agonists not onl...
46 CitationsSource
#1Vladimir IlyukhaH-Index: 5
Last.Tatyana O. VolkovaH-Index: 4
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Last.Nikolai Tyutyunnik (RAS: Russian Academy of Sciences)
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The activity and localization of enzymes in blood leukocytes were examined in dark brown (+/+), silver-blue (p/p) and sapphire (a/a p/p) minks during several periods of postnatal development. This study was performed by morphometric and cytochemical methods using light microscopy and image analysis software “VidеoTest». Significant genotypic differences were determined in the distribution of peroxidase, naphthol AS-D chloroacetate esterase (NASDCE) and alkaline phosphatase (AP) in leukocytes. Sa...
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#1Daniel R. Ram (Tufts University)H-Index: 5
#2Vladimir Ilyukha (PetrSU: Petrozavodsk State University)H-Index: 5
Last.Alexander Poltorak (Tufts University)H-Index: 18
view all 7 authors...
cFLIP, an inhibitor of apoptosis, is a crucial regulator of cellular death by apoptosis and necroptosis; its importance in development is exemplified by the embryonic lethality in cFLIP–deficient animals. A homolog of caspase 8 (CASP8), cFLIP exists in two main isoforms: cFLIPL (long) and cFLIPR (short). Although both splice variants regulate death receptor (DR)-induced apoptosis by CASP8, the specific role of each isoform is poorly understood. Here, we report a previously unidentified model of ...
15 CitationsSource
#1Guy Surpris (Tufts University)H-Index: 2
#2Jennie Chan (UMMS: University of Massachusetts Medical School)H-Index: 10
Last.Alexander PoltorakH-Index: 18
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With the stimulator of IFN genes (STING) C terminus being extensively studied, the role of the N-terminal domain (NTD) of STING remains an important subject of investigation. In this article, we identify novel mutations in NTD of Sting of the MOLF strain in response to HSV and Listeria monocytogenes both in vitro and in vivo. These mutations are responsible for low levels of IFN-β caused by failure of MOLF STING to translocate from the endoplasmic reticulum. These data provide evidence that the ...
10 CitationsSource
#1Alexander Poltorak (Tufts University)H-Index: 18
#2Olga V. Kurmyshkina (PetrSU: Petrozavodsk State University)H-Index: 2
Last.Tatyana O. Volkova (PetrSU: Petrozavodsk State University)H-Index: 4
view all 6 authors...
The cytoplasmic protein Stimulator of Interferon Genes (STING) plays an essential role in sensing cytoplasmic DNA of intracellular pathogens and initiating IFN type I responses in myeloid cells. It can also directly bind cyclic dinucleotides produced by intracellular bacteria or by the DNA-binding cyclic GMP-AMP (cGAMP) synthase. To date, the signaling mechanisms involving STING activation has been studied in macrophages and dendritic cells. Taking into consideration the fact that STING is highl...
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