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Alejandro Hoberman
University of Pittsburgh
SurgeryIntensive care medicineVesicoureteral refluxMedicineUrinary system
140Publications
37H-index
5,591Citations
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Publications 145
Newest
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Timothy R. Shope (University of Pittsburgh)H-Index: 11
Last. Howard E. Rockette (University of Pittsburgh)H-Index: 53
view all 20 authors...
BACKGROUND To evaluate the efficacy of adjuvant systemic corticosteroids in reducing kidney scarring. A previous study suggested that use of adjuvant systemic corticosteroids reduces kidney scarring in children radiologically confirmed to have extensive pyelonephritis. Efficacy of corticosteroids for children with febrile urinary tract infection (UTI) has not been studied. METHODS Children aged 2 months to 6 years with their first febrile UTI were randomized to corticosteroids or placebo for 3 d...
Source
#1Sonika Bhatnagar (University of Pittsburgh)H-Index: 3
#2Alejandro Hoberman (University of Pittsburgh)H-Index: 37
Last. Nader Shaikh (University of Pittsburgh)H-Index: 24
view all 7 authors...
Source
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Judith M. Martin (University of Pittsburgh)H-Index: 19
Last. Timothy R. Shope (University of Pittsburgh)H-Index: 11
view all 16 authors...
Background The specificity of the leukocyte esterase test (87%) is suboptimal. The objective of this study was to identify more specific screening tests that could reduce the number of children who unnecessarily receive antimicrobials to treat a presumed urinary tract infection (UTI).
1 CitationsSource
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Vinod Rajakumar (Boston Children's Hospital)H-Index: 1
Last. Alejandro Hoberman (University of Pittsburgh)H-Index: 37
view all 14 authors...
Objective: Antimicrobial prophylaxis for children with vesicoureteral reflux (VUR) reduces recurrences of urinary tract infection (UTI) but requires daily antimicrobials for extended periods. We used a cost-utility model to evaluate whether the benefits of antimicrobial prophylaxis outweigh its risks and, if so, to investigate whether the benefits and risks vary according to grade of VUR. Methods: We compared the cost per quality-adjusted life-year (QALY) gained in four treatment strategies in c...
1 CitationsSource
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Mary Ann Haralam (University of Pittsburgh)H-Index: 14
Last. Alejandro Hoberman (University of Pittsburgh)H-Index: 37
view all 4 authors...
Importance Although prior studies have suggested that the risk of renal scarring gradually increases with each febrile urinary tract infection (UTI), recent and detailed data are lacking. Objective To evaluate how the risk of renal scarring is associated with the number of febrile UTIs. Design, Setting, and Participants A post hoc analysis was performed from June 2018 to April 2019 of data collected in the context of 2 multicenter prospective studies (RIVUR [Randomized Intervention for Children ...
5 CitationsSource
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Marcia Kurs-Lasky (University of Pittsburgh)H-Index: 35
Last. Alejandro Hoberman (University of Pittsburgh)H-Index: 37
view all 3 authors...
Abstract Objective To modify a parent-reported scale we developed to follow symptoms of young children with acute otitis media (AOM-SOS) with the aim of improving its psychometric properties. Study design We modified version 4.0 of the scale by increasing the number of response options from 3 to 6. We compared the distribution of scores, internal reliability, construct validity, and responsiveness of versions 4.0 and 5.0 in children diagnosed with acute otitis media (AOM) in 2 studies. For Versi...
Source
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Judith M. Martin (University of Pittsburgh)H-Index: 19
Last. Timothy R. Shope (University of Pittsburgh)H-Index: 11
view all 20 authors...
Objective To determine whether treatment for urinary tract infections in children could be individualized using biomarkers for acute pyelonephritis. Study design We enrolled 61 children with febrile urinary tract infections, collected blood and urine samples, and performed a renal scan within 2 weeks of diagnosis to identify those with pyelonephritis. Renal scans were interpreted centrally by 2 experts. We measured inflammatory proteins in blood and urine using LUMINEX or an enzyme-linked immuno...
Source
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Ellen R. Wald (UW: University of Wisconsin-Madison)H-Index: 65
Last. Alejandro Hoberman (University of Pittsburgh)H-Index: 37
view all 11 authors...
Objective To develop a parent-reported Pediatric Rhinosinusitis Symptom Scale (PRSS) that could be used to monitor symptoms of young children with acute sinusitis in response to therapy. Study design We developed an 8-item symptom severity scale and evaluated its internal reliability, construct validity, and responsiveness in children 2-12 years of age with acute sinusitis. Parents of 258 children with acute sinusitis completed the PRSS at the time of diagnosis, as a diary at home, and at the fo...
Source
Oct 1, 2018 in ICIP (International Conference on Image Processing)
#1Manuel Martinello (Ricoh)H-Index: 1
#2Leonidas Spinoulas (Ricoh)H-Index: 9
Last. Alejandro Hoberman (Boston Children's Hospital)H-Index: 37
view all 9 authors...
Bulging is a medical characteristic of the eardrum that is crucial for the diagnosis of acute otitis media. This work proposes a novel classification method for distinguishing bulged eardrums from non-bulged ones. The method uses novel key features extracted from 3D data of the tympanic membrane, captured using a new type of otoscope, the light-field otoscope, capable of non-invasive 3D imaging of the middle ear. We first introduce a variety of geometrical and statistical descriptors (based on i...
1 CitationsSource
#1Nader Shaikh (University of Pittsburgh)H-Index: 24
#2Alejandro Hoberman (University of Pittsburgh)H-Index: 37
Last. Timothy R. Shope (University of Pittsburgh)H-Index: 11
view all 8 authors...
Importance Accurately estimating the probability of urinary tract infection (UTI) in febrile preverbal children is necessary to appropriately target testing and treatment. Objective To develop and test a calculator (UTICalc) that can first estimate the probability of UTI based on clinical variables and then update that probability based on laboratory results. Design, Setting, and Participants Review of electronic medical records of febrile children aged 2 to 23 months who were brought to the eme...
6 CitationsSource
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