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Matthew J. Nolan
Royal Veterinary College
VirologyDigeneaGeneticsBiologyZoology
52Publications
23H-index
1,383Citations
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Publications 57
Newest
#1Michael D. Hammond (RMIT: RMIT University)H-Index: 2
#2Thomas H. Cribb (UQ: University of Queensland)H-Index: 34
Last. Nathan J. Bott (RMIT: RMIT University)H-Index: 16
view all 4 authors...
Abstract We surveyed 14 individuals of Tylosurus crocodilus Peron & Lesueur 1821 (Belonidae) collected from the waters around Lizard Island and Heron Island, Great Barrier Reef, Queensland, Australia, and the waters around Moorea, French Polynesia. We describe two new species of bucephaline trematodes from them, Prosorhynchoides galaktionovi n. sp. and P. kohnae n. sp. They are morphologically distinct from existing Prosorhynchoides spp., with molecular data from 28S and ITS-2 ribosomal DNA, as ...
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#1Abi Bremner (Edin.: University of Edinburgh)
#2Sungwon Kim (Edin.: University of Edinburgh)H-Index: 11
Last. Lonneke Vervelde (Edin.: University of Edinburgh)H-Index: 30
view all 11 authors...
Eimeria maxima is a common cause of coccidiosis in chickens, a disease which has a huge economic impact on poultry production. Knowledge of immunity to E. maxima and the specific mechanisms that contribute to differing levels of resistance observed between chicken breeds and between congenic lines derived from a single breed of chickens is required. This study aimed to define differences in the kinetics of the immune response of two inbred lines of White Leghorn chickens that exhibit differentia...
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#1Kay Boulton (Edin.: University of Edinburgh)H-Index: 8
#2Matthew J. Nolan (RVC: Royal Veterinary College)H-Index: 23
Last. Androniki Psifidi (Edin.: University of Edinburgh)H-Index: 10
view all 17 authors...
Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher cost of live-attenuated vaccines, an attractive complementary strategy for control is to breed chickens with increased resistance to Eimeria parasitism. Prior infection with Eimeria maxima leads to complete immunity against challenge with homologous strains, but ...
1 CitationsSource
#1Kay Boulton (Edin.: University of Edinburgh)H-Index: 8
#2Matthew J. Nolan (RVC: Royal Veterinary College)H-Index: 23
Last. David A. Hume (Edin.: University of Edinburgh)H-Index: 101
view all 14 authors...
Coccidiosis is a major contributor to losses in poultry production. With emerging constraints on the use of in-feed prophylactic anticoccidial drugs and the relatively high costs of effective vaccines, there are commercial incentives to breed chickens with greater resistance to this important production disease. To identify phenotypic biomarkers that are associated with the production impacts of coccidiosis, and to assess their covariance and heritability, 942 Cobb500 commercial broilers were su...
4 CitationsSource
#1P. Sakkas (Newcastle University)H-Index: 7
#2Idiegberanoise Oikeh (Newcastle University)H-Index: 2
Last. Ilias Kyriazakis (Newcastle University)H-Index: 52
view all 9 authors...
Chickens exhibit varied responses to infection with Eimeria parasites. We hypothesise that broilers selected for increased growth rate will show lower resistance and tolerance to a coccidian challenge. 288 chickens of fast (F) or slow (S) growing lines were inoculated with 0 (control), 2500 (low-dose), or 7000 (high-dose) sporulated E. maxima oocysts at 13 days of age in two consecutive rounds. Gain and Intake were measured daily and their values relative to BW at the point of infection were cal...
8 CitationsSource
#1Matthew J. Nolan (RVC: Royal Veterinary College)H-Index: 23
#2Melisa Unger (RVC: Royal Veterinary College)H-Index: 1
Last. Damer P. Blake (RVC: Royal Veterinary College)H-Index: 24
view all 9 authors...
Over 60 % of human emerging infectious diseases are zoonotic, and there is growing evidence of the zooanthroponotic transmission of diseases from humans to livestock and wildlife species, with major implications for public health, economics, and conservation. Zooanthroponoses are of relevance to critically endangered species; amongst these is the mountain gorilla (Gorilla beringei beringei) of Uganda. Here, we assess the occurrence of Cryptosporidium, Cyclospora, Giardia, and Entamoeba infecting...
9 CitationsSource
#1Luke R. Thompson (UCSD: University of California, San Diego)H-Index: 21
#2Jon G. Sanders (UCSD: University of California, San Diego)H-Index: 24
Last. Hongxia ZhaoH-Index: 2
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Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Pr...
342 CitationsSource
#1Damer P. Blake (RVC: Royal Veterinary College)H-Index: 24
#2Iván Pastor-Fernández (RVC: Royal Veterinary College)H-Index: 3
Last. Fiona M. Tomley (RVC: Royal Veterinary College)H-Index: 38
view all 4 authors...
Eimeria species parasites can cause the disease coccidiosis, most notably in chickens. The occurrence of coccidiosis is currently controlled through a combination of good husbandry, chemoprophylaxis and/or live parasite vaccination; however, scalable, cost-effective subunit or recombinant vaccines are required. Many antigens have been proposed for use in novel anticoccidial vaccines, supported by the capacity to reduce disease severity or parasite replication, increase body weight gain in the fa...
10 CitationsSource
#1David WilsonH-Index: 15
#2Glen M. BoyleH-Index: 37
Last. Norelle L. DalyH-Index: 58
view all 11 authors...
Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA366, containing a hydroxyphenyl-based structure is present in the venom of several species of tarantula, and has selective toxicity against MCF-7 breast cancer cells. By contrast, a polyamine from an Australian funnel-web spider venom, which c...
4 CitationsSource
#1Sarah MacDonald (RVC: Royal Veterinary College)H-Index: 14
#2Matthew J. Nolan (RVC: Royal Veterinary College)H-Index: 23
Last. Damer P. Blake (RVC: Royal Veterinary College)H-Index: 24
view all 8 authors...
Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and production remains largely unknown, with the possible exception of Clostridium perfringens (necrotic enteritis). This study evaluated the composition and structure of the caecal microbiome in the presence or absence of a defined Eimeria tenella challenge...
13 CitationsSource
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