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Artur Schmidtchen
Nanyang Technological University
175Publications
40H-index
5,281Citations
Publications 175
Newest
Published on Jan 1, 2019in Wound Repair and Regeneration 2.95
Maja Olsson (Nanyang Technological University), Krister Järbrink3
Estimated H-index: 3
(Nanyang Technological University)
+ 4 AuthorsJosip Car43
Estimated H-index: 43
(Imperial College London)
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Published on Jan 1, 2019in Annals of Epidemiology 2.80
Laura Martinengo1
Estimated H-index: 1
(Nanyang Technological University),
Maja Olsson (Nanyang Technological University)+ 5 AuthorsKrister Järbrink3
Estimated H-index: 3
(Nanyang Technological University)
Abstract Purpose Chronic wounds are a major public health challenge, but little is known about the true burden with studies reporting different estimates because of disparities in study designs and measurement methods. This hampers efficient resource allocation, planning, and improvement of wound care. Methods Our study aimed to pool prevalence estimates from a global perspective by systematically carrying out searches in MEDLINE, EMBASE, Cochrane, CINAHL, Global Health, and PsycINFO databases f...
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Published on Dec 10, 2018in British Journal of Dermatology 6.13
Johan Palmgren (Lund University), John Paoli4
Estimated H-index: 4
(University of Gothenburg)
+ 1 AuthorsKarim Saleh2
Estimated H-index: 2
(Lund University)
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Published on Dec 1, 2018in Tuberculosis 2.73
Erik Tenland3
Estimated H-index: 3
(Lund University),
Nitya Krishnan7
Estimated H-index: 7
(Imperial College London)
+ 12 AuthorsIzabela Glegola-Madejska2
Estimated H-index: 2
(Imperial College London)
Abstract Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant Mycobacterium tuberculosis strains complicate treatment and increases mortality rates, making the development of new drugs an urgent priority. In this study we have identified a promising candidate by screening antimicrobial peptides for their capacity to inhibit mycobacterial growth. This non-toxic peptide, NZX, is capable of inhibi...
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Published on Mar 1, 2018in Journal of Colloid and Interface Science 5.09
Randi Nordström3
Estimated H-index: 3
(Uppsala University),
Lina Nyström3
Estimated H-index: 3
(Uppsala University)
+ 5 AuthorsMartin Malmsten51
Estimated H-index: 51
(Uppsala University)
Microgels are interesting as potential delivery systems for antimicrobial peptides. In order to elucidate membrane interactions of such systems, we here investigate effects of microgel charge density on antimicrobial peptide loading and release, as well as consequences of this for membrane interactions and antimicrobial effects, using ellipsometry, circular dichroism spectroscopy, nanoparticle tracking analysis, dynamic light scattering and z-potential measurements. Anionic poly(ethyl acrylate-c...
1 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Rathi Saravanan12
Estimated H-index: 12
(Nanyang Technological University),
Daniel A. Holdbrook9
Estimated H-index: 9
(Agency for Science, Technology and Research)
+ 7 AuthorsArtur Schmidtchen40
Estimated H-index: 40
(University of Copenhagen)
Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we here determine the bound conformation of HVF18 (HVFRLKKWIQKVIDQFGE), a TCP generated by neutrophil elastase, in complex with bacterial lipopolysaccharide (LPS) and define a previously undisclosed inte...
2 Citations Source Cite
Published on Jan 1, 2018in Acta Dermato-venereologica
Roopa S. Subbaiah1
Estimated H-index: 1
,
Swat Kim Kerk1
Estimated H-index: 1
+ 5 AuthorsSunil S. Adav31
Estimated H-index: 31
1 Citations Source Cite
Published on Aug 1, 2018in Structure 4.91
Roland G. Huber6
Estimated H-index: 6
(Agency for Science, Technology and Research),
Nils A. Berglund5
Estimated H-index: 5
(University of Southampton)
+ 6 AuthorsPeter J. Bond33
Estimated H-index: 33
(Agency for Science, Technology and Research)
Summary The Gram-negative bacterial outer membrane contains lipopolysaccharide, which potently stimulates the mammalian innate immune response. This involves a relay of specialized complexes culminating in transfer of lipopolysaccharide from CD14 to Toll-like receptor 4 (TLR4) and its co-receptor MD-2 on the cell surface, leading to activation of downstream inflammatory responses. In this study we develop computational models to trace the TLR4 cascade in near-atomic detail. We demonstrate throug...
1 Citations Source Cite
Published on Nov 1, 2018in Biochimica et Biophysica Acta 3.44
Daniel A. Holdbrook9
Estimated H-index: 9
(Agency for Science, Technology and Research),
Shalini Singh10
Estimated H-index: 10
(Uppsala University)
+ 6 AuthorsRathi Saravanan12
Estimated H-index: 12
(Nanyang Technological University)
Abstract The wound environment is characterized by physiological pH changes. Proteolysis of thrombin by wound-derived proteases, such as neutrophil elastase, generates antimicrobial thrombin-derived C-terminal peptides (TCPs), such as HVF18 (HVFRLKKWIQKVIDQFGE). Presence of such TCPs in human wound fluids in vivo , as well as the occurrence of an evolutionarily conserved His residue in the primary amino acid sequence of TCPs, prompted us to investigate the pH-dependent antibacterial action of HV...
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