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Artur Schmidtchen
University of Copenhagen
179Publications
41H-index
5,438Citations
Publications 179
Newest
Published on May 24, 2019in Experimental Dermatology 2.61
Bani Kaur Suri (Nanyang Technological University), Artur Schmidtchen41
Estimated H-index: 41
(University of Copenhagen),
Navin Kumar Verma19
Estimated H-index: 19
(Nanyang Technological University)
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Published on May 1, 2019in British Journal of Dermatology 6.13
Johan Palmgren (Lund University), John Paoli19
Estimated H-index: 19
(University of Gothenburg)
+ 1 AuthorsKarim Saleh3
Estimated H-index: 3
(Lund University)
BACKGROUND: Diagnosis of a surgical site infection (SSI) in dermatologic surgery can be entirely based on a subjective assessment according to the 4th criterion of the most common definition of an SSI, which was established by the US Centers for Disease Control (CDC).OBJECTIVES: To investigate the interobserver agreement between dermatologists in their diagnosis of SSI of dermatosurgical wounds.METHODS: An international electronic photographic survey with eight photographs of wounds 1 week after...
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Published on May 1, 2019in British Journal of Dermatology 6.13
J. Palmgren , John Paoli19
Estimated H-index: 19
+ 1 AuthorsKarim Saleh3
Estimated H-index: 3
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Published on May 1, 2019in ACS Applied Materials & Interfaces 8.10
Sara Malekkhaiat Häffner1
Estimated H-index: 1
,
Lina Nyström3
Estimated H-index: 3
(Uppsala University)
+ 5 AuthorsMartin Malmsten51
Estimated H-index: 51
(Uppsala University)
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Published on Jan 1, 2019in Annals of Epidemiology 2.80
Laura Martinengo1
Estimated H-index: 1
(Nanyang Technological University),
Maja Olsson1
Estimated H-index: 1
(Nanyang Technological University)
+ 5 AuthorsKrister Järbrink3
Estimated H-index: 3
(Nanyang Technological University)
Abstract Purpose Chronic wounds are a major public health challenge, but little is known about the true burden with studies reporting different estimates because of disparities in study designs and measurement methods. This hampers efficient resource allocation, planning, and improvement of wound care. Methods Our study aimed to pool prevalence estimates from a global perspective by systematically carrying out searches in MEDLINE, EMBASE, Cochrane, CINAHL, Global Health, and PsycINFO databases f...
1 Citations Source Cite
Published on Jan 1, 2019in Wound Repair and Regeneration 2.95
Maja Olsson1
Estimated H-index: 1
(Nanyang Technological University),
Krister Järbrink3
Estimated H-index: 3
(Nanyang Technological University)
+ 4 AuthorsJosip Car45
Estimated H-index: 45
(Imperial College London)
Chronic wounds are a health problem that have devastating consequences for patients and contribute major costs to healthcare systems and societies. To understand the magnitude of this health issue, a systematic review was undertaken. Searches were conducted in MEDLINE, EMBASE, EBM Reviews and Cochrane library, CINAHL, EBSCO, PsycINFO, and Global Health databases for articles published between 2000 and 2015. Included publications had to target adults (≥18 years of age), state wound chronicity (≥3...
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Published on Dec 1, 2018in Tuberculosis 2.73
Erik Tenland3
Estimated H-index: 3
(Lund University),
Nitya Krishnan7
Estimated H-index: 7
(Imperial College London)
+ 12 AuthorsIzabela Glegola-Madejska2
Estimated H-index: 2
(Imperial College London)
Abstract Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant Mycobacterium tuberculosis strains complicate treatment and increases mortality rates, making the development of new drugs an urgent priority. In this study we have identified a promising candidate by screening antimicrobial peptides for their capacity to inhibit mycobacterial growth. This non-toxic peptide, NZX, is capable of inhibi...
1 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Rathi Saravanan12
Estimated H-index: 12
(Nanyang Technological University),
Daniel A. Holdbrook10
Estimated H-index: 10
(Agency for Science, Technology and Research)
+ 7 AuthorsArtur Schmidtchen41
Estimated H-index: 41
(University of Copenhagen)
Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we here determine the bound conformation of HVF18 (HVFRLKKWIQKVIDQFGE), a TCP generated by neutrophil elastase, in complex with bacterial lipopolysaccharide (LPS) and define a previously undisclosed inte...
3 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Sunil S. Adav31
Estimated H-index: 31
(Nanyang Technological University),
Roopa Shree Subbaiaih1
Estimated H-index: 1
(Nanyang Technological University)
+ 5 AuthorsArtur Schmidtchen41
Estimated H-index: 41
(University of Copenhagen)
Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and disease. Human hair proteins were extracted by detergent and detergent-free techniques. We adopted a shotgun proteomics approach, which demonstrated a large extractability and variety of hair proteins after detergent extraction. We found an enrichm...
2 Citations Source Cite
Published on Nov 1, 2018in Biochimica et Biophysica Acta 3.44
Daniel A. Holdbrook10
Estimated H-index: 10
(Agency for Science, Technology and Research),
Shalini Singh6
Estimated H-index: 6
(Uppsala University)
+ 6 AuthorsRathi Saravanan12
Estimated H-index: 12
(Nanyang Technological University)
Abstract The wound environment is characterized by physiological pH changes. Proteolysis of thrombin by wound-derived proteases, such as neutrophil elastase, generates antimicrobial thrombin-derived C-terminal peptides (TCPs), such as HVF18 (HVFRLKKWIQKVIDQFGE). Presence of such TCPs in human wound fluids in vivo , as well as the occurrence of an evolutionarily conserved His residue in the primary amino acid sequence of TCPs, prompted us to investigate the pH-dependent antibacterial action of HV...
1 Citations Source Cite
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