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Wenhai Deng
Wenzhou Medical College
ImmunologyTOR Serine-Threonine KinasesCell growthBiologymTORC1
4Publications
2H-index
48Citations
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Publications 6
Newest
#1Yun Pan (WMU: Wenzhou Medical College)H-Index: 1
#2Wenhai Deng (WMU: Wenzhou Medical College)H-Index: 2
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 12 authors...
1 CitationsSource
#1Pengcheng ChenH-Index: 2
#2Shang WangH-Index: 3
Last. Xiao-Ping ZhongH-Index: 30
view all 11 authors...
Source
#1Yun PanH-Index: 1
#2Wenhai DengH-Index: 2
Last. Xiao-Ping ZhongH-Index: 30
view all 12 authors...
Source
#1Pengcheng Chen (WMU: Wenzhou Medical College)H-Index: 2
#2Wenhai Deng (WMU: Wenzhou Medical College)H-Index: 2
Last. Jimin Gao (WMU: Wenzhou Medical College)H-Index: 8
view all 18 authors...
Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer. The influence of age on levels and functional characteristics of circulating MAIT cells have not been fully addressed. Here we have collected blood samples from a large cohort of healthy Chinese individuals from newborn (cord blood) to the elderly and assessed the levels of circulating MAIT cells as well ...
2 CitationsSource
#1Wenhai Deng (WMU: Wenzhou Medical College)H-Index: 2
#2Jialong Yang (Duke University)H-Index: 24
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 6 authors...
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did no...
9 CitationsSource
#1Jinwook ShinH-Index: 18
#2Shang Wang (WMU: Wenzhou Medical College)H-Index: 3
Last. Xiao-Ping Zhong (Duke University)H-Index: 30
view all 6 authors...
The mechanisms that control invariant natural killer T (iNKT)-cell development and function are still poorly understood. The mechanistic or mammalian target of rapamycin (mTOR) integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival. We report here that ablation of mTOR complex 1 (mTORC1) signaling by conditionally deleting Raptor causes severe defects in iNKT-cell development at early stages, leading to drastic reductions in iNKT-cell numbe...
37 CitationsSource
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