Khalid Al-Rasadi
Sultan Qaboos University
EndocrinologyCardiologyCholesterolDiabetes mellitusMedicine
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Publications 90
#1Sajad Dehnavi (Ahvaz Jundishapur University of Medical Sciences)H-Index: 1
#2Nasrollah Sohrabi (Kermanshah University of Medical Sciences)H-Index: 3
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 68
view all 8 authors...
HMG-CoA reductase inhibitors, or statins, are potent plasma LDL-cholesterol (LDL-c) lowering agents. Since the introduction of the first statin, lovastatin, in 1987, accumulating evidence showed that non-cholesterol lowering effects play an important role in their efficacy to reduce atherosclerotic cardiovascular disease (ASCVD). Thus, these non-LDL-c lowering properties could benefit patients with immune-mediated diseases. Statins and their associated immune-modulating roles have recently recei...
#1Fatemeh Zahedipour (MUMS: Mashhad University of Medical Sciences)
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 68
view all 8 authors...
Coronavirus disease 2019 (COVID-19) outbreak is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with considerable mortality worldwide. The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. Curcumin, a natural polyphenolic compou...
#1Khadijeh Koushki (MUMS: Mashhad University of Medical Sciences)H-Index: 2
#2Sanaz Keshavarz Shahbaz (MUMS: Mashhad University of Medical Sciences)H-Index: 2
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 68
view all 10 authors...
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome and TLRs. Some of the statins lead to activation of the inflammasome and subsequently cause...
2 CitationsSource
#1Željko Reiner (University Hospital Centre Zagreb)H-Index: 54
#1Zeljko ReinerH-Index: 1
Last. Amirhossein SahebkarH-Index: 68
view all 9 authors...
Introduction: No proven drug and no immunisation are yet available for COVID-19 disease. The SARS-CoV-2 main protease (Mpro), a key coronavirus enzyme, which is a potential drug target, has been successfully crystallised. There is evidence suggesting that statins exert anti-viral activity and may block the infectivity of enveloped viruses. The aim of this study was to assess whether statins are potential COVID-19 Mpro inhibitors, using a molecular docking study. Material and methods: Molecular d...
7 CitationsSource
#1Lieven Annemans (UGent: Ghent University)H-Index: 38
#2Joseph Azuri (TAU: Tel Aviv University)H-Index: 9
Last. Nicolas DanchinH-Index: 59
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BACKGROUND: Few recent large-scale studies have examined healthcare consumption associated with dyslipidemia in countries outside Western Europe and North America. METHODS: This analysis, from a cross-sectional observational study conducted in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America, evaluated avoidable healthcare consumption (defined as >/=1 hospitalization for cardiovascular reasons or >/=1 visit to the emergency room for any reason in the previous 12 mo...
#2Akshaya Srikanth Bhagavathula (United Arab Emirates University)H-Index: 9
#3Abdulla Shehab (College of Health Sciences, Bahrain)H-Index: 10
Last. Saif Al-Shamsi (United Arab Emirates University)H-Index: 2
view all 5 authors...
AIM: We investigated the incidence of adverse drug reactions (ADRs) in patients treated with statins for cardiovascular (CV) risk among the United Arab Emirates (UAE) population. METHODS: This is a retrospective cohort study conducted among statin users attending 2 tertiary care centres: Al Ain and Tawam hospitals in Al Ain city, UAE. We retrieved the clinical profile of all the patients taking statins from January 2011 to January 2015 using our electronic database (Cerner®). RESULTS: Among 556 ...
#2Katherine WilemonH-Index: 11
Last. Samuel S. GiddingH-Index: 60
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Importance Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated genetic disorder that leads to premature morbidity and mortality due to atherosclerotic cardiovascular disease. Familial hypercholesterolemia affects 1 in 200 to 250 people around the world of every race and ethnicity. The lack of general awareness of FH among the public and medical community has resulted in only 10% of the FH population being diagnosed and adequately treated. The World Health Organization recogn...
9 CitationsSource
#1Abdulla Shehab (United Arab Emirates University)H-Index: 10
#2Akshaya Srikanth Bhagavathula (United Arab Emirates University)H-Index: 9
Last. Ridha MustafaH-Index: 1
view all 7 authors...
BACKGROUND: The prevalence of traditional risk factors such as diabetes mellitus (DM) and obesity are increasing in patients with acute coronary syndrome (ACS). Furthermore, outcomes after ACS are worse in patients with DM. The high prevalence of DM and an early age at onset of ACS have been described in prior publications from the Gulf Coast Database. AIM: We aimed to define the effect of DM on total mortality following ACS presentation at 30-days and 1 year based on the Gulf COAST registry dat...
#1Khalid Al-Rasadi (Sultan Qaboos University)H-Index: 19
#2Khalid F. AlHabib (KSU: King Saud University)H-Index: 25
Last. Hani Altaradi (KSU: King Saud University)H-Index: 3
view all 23 authors...
AIM: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region. METHOD: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. In Phase 1, suspected FH patients (category 1) were collected according to the lipid profile and clinical data obtained through hospital record sy...
#1Armita Mahdavi Gorabi (Tehran University of Medical Sciences)H-Index: 5
#2Saeideh Hajighasemi (QUMS: Qazvin University of Medical Sciences)H-Index: 2
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 68
view all 7 authors...
Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, which produce high amounts of extracellular matrix (ECM) proteins leading, in turn, to excessive deposition of ECM in cardiac tissue. The excessive accumulation of ECM elements causes heart stiffness, tissue scarring, electrical conduction disruption a...
2 CitationsSource