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Ashiya Buckels
University of Alabama at Birmingham
Receptor tyrosine kinaseMolecular biologyJanus kinase 2Tyrosine kinaseBiology
4Publications
2H-index
32Citations
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Publications 3
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#1Ashiya Buckels (UAB: University of Alabama at Birmingham)H-Index: 2
#2Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 7 authors...
Abstract Melanoma is the most aggressive skin cancer. Its aggressiveness is most commonly attributed to ERK pathway mutations leading to constitutive signaling. Though initial tumor regression results from targeting this pathway, resistance often emerges. Interestingly, interrogation of the NCI-60 database indicates high growth hormone receptor (GHR) expression in melanoma cell lines. To further characterize melanoma, we tested responsiveness to human growth hormone (GH). GH treatment resulted i...
1 CitationsSource
#1Yujun Gan (UAB: University of Alabama at Birmingham)H-Index: 6
#2Ashiya Buckels (UAB: University of Alabama at Birmingham)H-Index: 2
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 8 authors...
GH signaling yields multiple anabolic and metabolic effects. GH binds the transmembrane GH receptor (GHR) to activate the intracellular GHR-associated tyrosine kinase, Janus kinase 2 (JAK2), and downstream signals, including signal transducer and activator of transcription 5 (STAT5) activation and IGF-1 gene expression. Some GH effects are partly mediated by GH-induced IGF-1 via IGF-1 receptor (IGF-1R), a tyrosine kinase receptor. We previously demonstrated in non-human cells that GH causes form...
16 CitationsSource
#1Yujun Gan (UAB: University of Alabama at Birmingham)H-Index: 6
#2Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 10 authors...
GH is a potent anabolic and metabolic factor that binds its cell surface receptor (GHR), activating the GHR-associated tyrosine kinase, Janus kinase 2, which phosphorylates and activates the latent transcription factor, signal transducer and activator of transcription 5 (STAT5). Some GH actions are mediated by the elaboration of IGF-1, which exerts effects by binding and activating the heterotetrameric tyrosine kinase growth factor receptor, IGF-1R. In addition to this GH-GHR-IGF-1-IGF-1R scheme...
11 CitationsSource
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