Marco Demaria
University of Groningen
SenolyticCancer researchSenescenceBiologyCell biology
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Publications 64
Abstract Treatment of testicular cancer (TC) has an exceptionally high success rate compared to other cancer types; even in case of metastasized disease, 80-90% of TC patients can be cured. Consequently, attention has been drawn to a potential downside of this treatment success: late adverse treatment effects such as the accelerated development of otherwise age-associated features like cardiovascular disease and second malignancies. Underlying mechanisms are poorly understood. Emerging data sugg...
#1Abel Soto-GamezH-Index: 1
#2Deng ChenH-Index: 1
Last. L Ykelien
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Dysregulated epidermal growth factor receptor (EGFR) is an oncogenic driver of many human cancers, promoting aberrant cell proliferation, migration, and survival. Pharmacological targeting of EGFR is often challenged by acquired mechanisms of resistance. Ligand-dependent mechanisms in EGFR wild-type cells rely on ligand or receptor overexpression, allowing cells to outcompete inhibitors and perpetuate signaling in an autocrine manner. Importantly, EGFR ligands are synthesized as membrane-bound p...
#1Christopher D. Wiley (Buck Institute for Research on Aging)H-Index: 8
#2Rishi Sharma (Buck Institute for Research on Aging)H-Index: 6
Last. Marco Demaria (Buck Institute for Research on Aging)H-Index: 26
view all 12 authors...
SummaryCellular senescence is a stress or damage response that results in a permanent proliferative arrest and secretion of numerous factors with potent biological activities. This senescence-associated secretory phenotype (SASP) has been characterized largely for secreted proteins that participate in embryogenesis, wound healing, inflammation and many age-related pathologies. By contrast, lipid components of the SASP have been understudied. We show that senescent cells activate the biosynthesis...
#2Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
Last. Marco Demaria (UMCG: University Medical Center Groningen)H-Index: 26
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Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellula...
42 CitationsSource
#1Christopher D. Wiley (Buck Institute for Research on Aging)H-Index: 8
#2Su Liu (Buck Institute for Research on Aging)H-Index: 5
Last. Pankaj Kapahi (Buck Institute for Research on Aging)H-Index: 39
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Summary Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids (SILACs) and cultured cells, we identify 343 SASP proteins that senescent human fibroblasts secrete at 2-fold or higher levels compared with quiescent cell counterparts. Bioinformatic analysis reveals that 44 of these proteins participate in hemostasi...
3 CitationsSource
#1Lina Palacio (UdeM: Université de Montréal)H-Index: 3
#2Marie-Lyn Goyer (UdeM: Université de Montréal)H-Index: 1
Last. Christian M. Beauséjour (UdeM: Université de Montréal)H-Index: 27
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Some studies show eliminating senescent cells rejuvenate aged mice and attenuate deleterious effects of chemotherapy. Nevertheless, it remains unclear whether senescence affects immune cell function. We provide evidence that exposure of mice to ionizing radiation (IR) promotes the senescent-associated secretory phenotype (SASP) and expression of p16(INK4a) in splenic cell populations. We observe splenic T cells exhibit a reduced proliferative response when cultured with allogenic cells in vitro ...
1 CitationsSource
#1Abel Soto-GamezH-Index: 1
#2Wim J. QuaxH-Index: 45
Last. Marco Demaria (D.A.R.E.: Drug Abuse Resistance Education)H-Index: 26
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Cellular senescence is a state of stable cell cycle arrest arising in response to DNA and mitochondrial damages. Senescent cells undergo morphological, structural and functional changes that are influenced by a number of variables, including time, stress, tissue, and cell type. The heterogeneity of the senescent phenotype is exemplified by the many biological properties that senescent cells can cover. The advent of innovative model organisms has demonstrated a functional role of senescent cells ...
#1Prashanti Patil (University of Pittsburgh)H-Index: 2
#2Qing Dong (University of Pittsburgh)H-Index: 7
Last. Nam Vo (University of Pittsburgh)H-Index: 24
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Author(s): Patil, Prashanti; Dong, Qing; Wang, Dong; Chang, Jianhui; Wiley, Christopher; Demaria, Marco; Lee, Joon; Kang, James; Niedernhofer, Laura J; Robbins, Paul D; Sowa, Gwendolyn; Campisi, Judith; Zhou, Daohong; Vo, Nam | Abstract: RATIONALE:Age-related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest and chronically ...
1 CitationsSource
#1Allyson K. Palmer (Mayo Clinic)H-Index: 12
#2Ming Xu (UConn: University of Connecticut)H-Index: 20
Last. James L. KirklandH-Index: 55
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Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of diabetes remains to be demonstrated. Here, we show that reducing senescent cell burden in obese mice, either by activating drug-inducible "suicide" genes driven by the p16(Ink4a) promo...
12 CitationsSource
#1Arianna Calcinotto (UMCG: University Medical Center Groningen)H-Index: 1
#2Jaskaren KohliH-Index: 2
Last. Andrea AlimontiH-Index: 23
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Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that prevent...
7 CitationsSource