Gerard J. M. Martens
Radboud University Nijmegen
Publications 206
#1L van de Wijer (Radboud University Nijmegen)H-Index: 1
#2L. Pereira Garcia (Radboud University Nijmegen)H-Index: 1
Last.Judith R. Homberg (Radboud University Nijmegen)H-Index: 35
view all 12 authors...
Efavirenz is recommended as a preferred first-line drug for women of childbearing potential living with human immunodeficiency virus. Efavirenz is known for its central nervous system side effects, which are partly mediated by serotonergic actions. The neurotransmitter serotonin exerts neurotrophic effects during neurodevelopment and antenatal exposure to serotonergic agents has been linked to developmental delay. Although the teratogenic risks of efavirenz appear to be minimal, data on long-ter...
1 CitationsSource
#1Christine BusH-Index: 1
#2Christine Bus (University of Tübingen)H-Index: 2
Last.Julia C. Fitzgerald (University of Tübingen)H-Index: 8
view all 27 authors...
Mitochondrial dysfunction contributes to the pathogenesis of Parkinson9s disease but it is not clear why inherent mitochondrial defects lead specifically to the death of dopaminergic neurons of the mid brain. PINK1 is mitochondrial kinase and PINK1 mutations cause early onset Parkinson9s disease. We found that in neuronal progenitors, PINK1 regulates mitochondrial morphology, mitochondrial contact to the endoplasmic reticulum (ER) and the phosphorylation of Miro1. A compensatory metabolic shift ...
Myelination of neuronal axons is essential for proper brain functioning and requires mature myelinating oligodendrocytes (myOLs). The human OL cell lines HOG and MO3.13 have been widely used as in vitro models to study OL (dys) functioning. Here we applied a number of protocols aimed at differentiating HOG and MO3.13 cells into myOLs. However, none of the differentiation protocols led to increased expression of terminal OL differentiation or myelin-sheath formation markers. Surprisingly, the app...
#1Helena Xicoy (Radboud University Nijmegen)H-Index: 3
#2Jos F. Brouwers (UU: Utrecht University)H-Index: 34
Last.Gerard J. M. MartensH-Index: 40
view all 5 authors...
Parkinson’s disease (PD) is a highly prevalent neurodegenerative disease for which no disease-modifying treatments are available, mainly because knowledge about its pathogenic mechanism is still incomplete. Recently, a key role for lipids emerged, but lipid profiling of brain samples from human subjects is demanding. Here, we used an unbiased approach, lipidomics, to determine PD-linked changes in the lipid profile of a well-established cell model for PD, the catecholaminergic neuronal cell line...
1 CitationsSource
#1Judith R. Homberg (Radboud University Nijmegen Medical Centre)H-Index: 35
#2Peter Karel (Radboud University Nijmegen Medical Centre)H-Index: 5
Last.Michel M.M. Verheij (Radboud University Nijmegen)H-Index: 13
view all 14 authors...
Cocaine is known to increase the extracellular levels of dopamine (DA) and serotonin (5-HT) by inhibiting the neuronal reuptake of these monoamines. However, individuals with reduced monoamine reuptake transporter expression do not display a reduction in cocaine intake, suggesting that a mechanism other than inhibition of monoamine reuptake contributes to the rewarding and addictive effects of the psychostimulant. Here we report that cocaine depletes the dopaminergic and serotonergic storage ves...
#1Cassandra Sampaio-Baptista (University of Oxford)H-Index: 11
#2Astrid Valles (Radboud University Nijmegen)
Last.Heidi Johansen-Berg (University of Oxford)H-Index: 81
view all 13 authors...
White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI). However, it remains unclear which mechanisms drive or underlie WM plasticity in adulthood. Here, we combined DTI and mRNA expression analysis and examined the effects of somatosensory experience in adult rats. Somatosensory experience resulted in differences in WM and grey matter structure. C-FOS mRNA ...
#1Lidiane P. Garcia (Radboud University Nijmegen)H-Index: 1
#2Josefine S. Witteveen (Radboud University Nijmegen)H-Index: 2
Last.Sharon M. Kolk (Radboud University Nijmegen)H-Index: 10
view all 7 authors...
Proper development of the medial prefrontal cortex (mPFC), crucial for correct cognitive functioning, requires projections from, among others, the serotonergic (5-HT) and catecholaminergic systems, but it is unclear how these systems influence each other during development. Here, we describe the parallel development of the 5-HT and catecholaminergic prefrontal projection systems in rat and demonstrate a close engagement of both systems in the proximity of Cajal-Retzius cells. We further show tha...
1 CitationsSource
#1Helena XicoyH-Index: 3
#2Bé WieringaH-Index: 51
Last.Gerard J. M. MartensH-Index: 40
view all 3 authors...
Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and microgliosis. During the past decades multiple cellular pathways have been associated with PD pathology (i.e., oxidative stress, endosomal-lysosomal dysfunction, endoplasmic reticulum stress, and immune response), yet disease-modifying treatments are not available. We have recently used genetic data from familial and spo...
5 CitationsSource
#1Jacob C. Garza (Harvard University)H-Index: 10
#2Xiaoli Qi (Harvard University)H-Index: 1
Last.Tracey L. Petryshen (Harvard University)H-Index: 25
view all 7 authors...
Background Ankyrin3 has been identified as a risk gene for Bipolar Disorder (BD) and autism spectrum disorders by multiple genome-wide and targeted association studies as well as sequencing studies. Carriers of the BD risk alleles have reduced ankyrin3 expression in the brain, suggesting that ankyrin3 suppression contributes to disease. However, the mechanism through which ankyrin3 confers risk is unknown. Ankyrin3 encodes the ankyrinG protein that tethers integral membrane proteins to the cytos...
#1Jacob C. Garza (Broad Institute)H-Index: 10
#2Xiaoli Qi (Broad Institute)H-Index: 1
Last.Tracey L. Petryshen (Broad Institute)H-Index: 25
view all 13 authors...
The ankyrin 3 gene (ANK3) is a well-established risk gene for psychiatric illness, but the mechanisms underlying its pathophysiology remain elusive. We examined the molecular effects of disrupting brain-specific Ank3 isoforms in mouse and neuronal model systems. RNA sequencing of hippocampus from Ank3+/− and Ank3+/+ mice identified altered expression of 282 genes that were enriched for microtubule-related functions. Results were supported by increased expression of microtubule end-binding protei...
5 CitationsSource