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Yoshiyuki Chiba
Osaka University
Organic chemistryChemistryEicosapentaenoic acidDocosahexaenoic acidBiochemistry
17Publications
10H-index
393Citations
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Publications 17
Newest
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Mariko Morishita (Hoshi University)H-Index: 38
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 5 authors...
We investigated the effect of fatty acids such as stearic acid (SA, 18:0), oleic acid (OA, 18:1), eicosapentaenoic acid (EPA, 20:5), and docosahexaenoic acid (DHA, 22:6) on a dipalmitoylphosphatidylcholine (DPPC) bilayer by determining the phase transition temperature, fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH), and detergent insolubility. Treatment with unsaturated fatty acid broadened and shifted the phase transitions of the DPPC bilayer to a lower temperature. The phase tr...
31 CitationsSource
#1Yoshinori OnukiH-Index: 15
#2Mariko MorishitaH-Index: 38
Last. Tsuneji NagaiH-Index: 53
view all 7 authors...
The purpose of this study was to evaluate the effectiveness of polyunsaturated fatty acid, docosahexaenoic acid (DHA), as a potential absorption enhancer for insulin from the intestinal membrane, using a water-in-oil-in-water multiple emulsion in an in situ study. When the emulsion containing various fatty acids was administered to the rectum, the enhancement effects of insulin absorption by DHA were stronger than those of medium chain fatty acid such as capric acid and lauric acid, and the phar...
5 Citations
#1Mariko Morishita (Hoshi University)H-Index: 38
#2Jose Mario Barichello (Hoshi University)H-Index: 4
Last. Tsuneji Nagai (Hoshi University)H-Index: 53
view all 6 authors...
Abstract The present study investigated the release profiles of insulin from Pluronic F-127 (PF-127) gel containing unsaturated fatty acids such as oleic acid (18:1), eicosapentaenoic acid (20:5) or docosahexaenoic acid (22:6) and the hypoglycemic effect of insulin following the buccal administration of the gel formulations in normal rats. Insulin release from the gels decreased in the presence of unsaturated fatty acids. Remarkable and continuous hypoglycemia was induced by all PF-127 gels (ins...
115 CitationsSource
#1Masako Kajita (Hoshi University)H-Index: 4
#2Mariko Morishita (Hoshi University)H-Index: 38
Last. Tsuneji Nagai (Hoshi University)H-Index: 53
view all 6 authors...
Abstract The aim of this study was to evaluate the potential of an emulsion incorporating unsaturated fatty acids to improve the mucosal absorption of poorly absorbed drugs from rat intestinal loops in situ , using a water‐in‐oil‐in‐water (W/O/W) multiple emulsion. Vancomycin hydrochloride (VCM) was used as a model drug with low oral bioavailability. The entrapment efficiency of VCM in the emulsion was ∼60% and remained constant over storage for 1 month at 4°C. The emulsion incorporating C18 uns...
18 CitationsSource
#1Mariko Morishita (Hoshi University)H-Index: 38
#2Masako Kajita (Hoshi University)H-Index: 4
Last. Tsuneji Nagai (Hoshi University)H-Index: 53
view all 7 authors...
Abstract The dose-related pharmacological effects of insulin emulsion incorporating highly purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were investigated. Water-in-oil-in-water multiple emulsions (insulin dose, 0, 10, 25 and 50 IU/kg) incorporating 2% DHA or EPA were administered directly into the colonic and rectal loops in situ. Serum insulin levels rose and serum glucose levels decreased in an insulin dose-related fashion. The relationship of insulin dose and C max or A...
22 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Mariko Morishita (Hoshi University)H-Index: 38
Last. Tsuneji Nagai (Hoshi University)H-Index: 53
view all 7 authors...
Abstract The purpose of this study was to evaluate the effectiveness and the toxicity of polyunsaturated fatty acid, such as oleic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as a potential absorption enhancer for rectal delivery of insulin, using a water-in-oil-in-water (W/O/W) multiple emulsion. In a single administration study, rectal insulin absorption was enhanced markedly, and marked hypoglycemia was induced by the emulsion incorporating various fatty acids in an insu...
49 CitationsSource
#1Jose Mario Barichello (Hoshi University)H-Index: 4
#2Mariko Morishita (Hoshi University)H-Index: 38
Last. Tsuneji Nagai (Hoshi University)H-Index: 53
view all 6 authors...
Abstract The objective of this study was to prepare and to evaluate Pluronic F-127 (PF127) gel containing unsaturated fatty acids such as oleic acid (18:1), eicosapentaenoic acid (20:5) and docosahexaenoic acid (22:6) as a potential formulation for rectal delivery of insulin. The hypoglycemic effect of insulin was examined following rectal administration of the various formulations in normal rats. Rectal insulin absorption was markedly enhanced, and marked hypoglycemia was induced by all PF127 g...
44 CitationsSource
#1Atsuyuki SuzukiH-Index: 2
#2Mariko Morishita (Hoshi University)H-Index: 38
Last. Tsuneji Nagai (Hoshi University)H-Index: 53
view all 8 authors...
The aim of this study was to test the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on insulin absorption from rat intestinal loops in situ, using a water-in-oil-in-water (W/O/W) multiple emulsion. The enhancement effect of these long-chain polyunsaturated fatty acids was compared with that of free fatty acids having a C18 alkyl chain. The emulsion (insulin dose, 50 units/kg) was administered directly into the colonic and rectal loops. Both EPA and DHA strongly enhanced i...
47 CitationsSource
#1YutakakawashimaH-Index: 12
#2Masakazu SatoH-Index: 5
Last. Katsuo HatayamaH-Index: 13
view all 8 authors...
We have recently reported that 4-[2-(4-substituted phenylsulfonylamino)ethylthio]phenoxyacetic acids and related compounds showed potent thromboxane A2 (TXA2) receptor antagonist activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) was analyzed by using the Hansch-Fujita method for 36 compounds, including newly synthesized compounds. The positive coefficient for πR and FR in the results of the QSAR study suggested that a...
4 CitationsSource
#1Masakazu SatoH-Index: 13
#2YutakakawashimaH-Index: 12
Last. Chuzo Iwata (Osaka University)H-Index: 18
view all 8 authors...
Summary A series of sulotroban-related arylsulfonamide derivatives possessing a fluorinated phenoxyacetic acid moiety was synthesized and tested for TXA 2 antagonizing ability on U-46619-induced platelet aggregation of rabbit platelet-rich plasma. Introduction of one or more fluorine atoms to the phenoxyacetic acid moiety increased this activity. The most potent compound among these compounds was 10c , which was 40-fold more potent (IC 50 3.4 × 10 −7 M) than sulotroban. 10c exhibited high activi...
16 CitationsSource
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