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Eleftherios P. Diamandis
University of Toronto
1,146Publications
99H-index
41.2kCitations
Publications 1124
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#1Ashley Di MeoH-Index: 6
#2Marshall D. Brown (Fred Hutchinson Cancer Research Center)H-Index: 6
Last.George M. Yousef (U of T: University of Toronto)H-Index: 50
view all 6 authors...
Abstract Background Renal cell carcinoma (RCC) is often detected incidentally as a small renal mass (SRM; pT1a, ≤ 4 cm). It is clinically challenging to predict progression in patients with SRMs. This is largely due to the recent recognition of clinically progressive and non-progressive RCC-SRMs. It is critical to accurately stratify SRM patients according to risk to avoid unnecessary treatment. This is especially significant for elderly and infirm patients, where the risk of surgery outweighs m...
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#1Clare Fiala (MSH: Mount Sinai Hospital, Toronto)H-Index: 5
#2Eleftherios P. Diamandis (U of T: University of Toronto)H-Index: 99
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#1Panagiota Filippou (U of T: University of Toronto)H-Index: 16
#2Annie H. Ren (U of T: University of Toronto)
Last.James R. Conner (U of T: University of Toronto)
view all 7 authors...
Abstract Objectives Kallikrein-related peptidases (KLKs) are a subgroup of 15 secreted chymotrypsin- and trypsin-like serine proteases that have been reported to possess novel functions in innate immunity and inflammation. Since the potential role of KLKs in immunity has not been studied in detail at the protein level, we examined the expression pattern of 12 members of the KLK family in immune-related tissues. Design & Methods Protein expression in tissue extracts was evaluated using immunoassa...
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#1Milena Music (U of T: University of Toronto)H-Index: 1
#2Antoninus Soosaipillai (MSH: Mount Sinai Hospital, Toronto)H-Index: 35
Last.Eleftherios P. DiamandisH-Index: 99
view all 6 authors...
Background Autoantibodies are produced when tolerance to self-antigens is broken and they can be mediators of tissue injury and systemic inflammation. They are excellent biomarkers because they are minimally invasive to screen and are highly abundant in serum due to limited proteolysis and slow clearance. Conventionally used methods of identifying autoantibodies in patient sera include indirect immunofluorescence, enzyme-linked immunoabsorbent assays (ELISAs) and protein microarrays. Here we pre...
1 CitationsSource
#1Clare Fiala (MSH: Mount Sinai Hospital, Toronto)H-Index: 5
#2Eleftherios P. Diamandis (U of T: University of Toronto)H-Index: 99
Circulating cell-free DNA (cfDNA), released from normal and cancerous cells, is an exciting new biomarker. Circulating tumor DNA (ctDNA) usually contains genetic changes that could be useful for detecting cancer. Various laboratories have reported impressive clinical data, with cancer detection sensitivities ranging from 50 to 70%, calculated at 90–95% specificities [1–3]. ctDNA has additional important applications, including prognosis, monitoring therapy and estimating tumor volume [4]. These ...
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#1Milena Music (U of T: University of Toronto)H-Index: 1
#2Antoninus Soosaipillai (MSH: Mount Sinai Hospital, Toronto)H-Index: 35
Last.Eleftherios P. DiamandisH-Index: 99
view all 6 authors...
In the original version of the article [1], an error was noticed under the heading “Immunoprecipitation on protein G magnetic beads” in “Methods” section.
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#1Jaimie Dufresne (RyeU: Ryerson University)H-Index: 4
#2Pete Bowden (RyeU: Ryerson University)H-Index: 2
Last.John G. Marshall (RyeU: Ryerson University)H-Index: 20
view all 25 authors...
Background There is a need to demonstrate a proof of principle that proteomics has the capacity to analyze plasma from breast cancer versus other diseases and controls in a multisite clinical trial design. The peptides or proteins that show a high observation frequency, and/or precursor intensity, specific to breast cancer plasma might be discovered by comparison to other diseases and matched controls. The endogenous tryptic peptides of breast cancer plasma were compared to ovarian cancer, femal...
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