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Jacob B. Campbell
Arizona State University
HemolymphEndocrinologyHoney beeDrosophila melanogasterBiology
10Publications
4H-index
90Citations
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Publications 10
Newest
#1Jon F. Harrison (ASU: Arizona State University)H-Index: 42
#2Khaled Adjerid (VT: Virginia Tech)H-Index: 2
Last. John J. Socha (VT: Virginia Tech)H-Index: 21
view all 12 authors...
Gravity is one of the most ubiquitous environmental effects on living systems: Cellular and organismal responses to gravity are of central importance to understanding the physiological function of organisms, especially eukaryotes. Gravity has been demonstrated to have strong effects on the closed cardiovascular systems of terrestrial vertebrates, with rapidly responding neural reflexes ensuring proper blood flow despite changes in posture. Invertebrates possess open circulatory systems, which co...
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#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Paula F. Overby (ASU: Arizona State University)H-Index: 2
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
view all 5 authors...
As the genetic bases to variation in anoxia tolerance are poorly understood, we used the Drosophila Genetics Reference Panel (DGRP) to conduct a genome-wide association study (GWAS) of anoxia tolerance in adult and larval Drosophila melanogaster. Survival ranged from 0-100% in adults exposed to 6 h of anoxia and from 20-98% for larvae exposed to 1 h of anoxia. Anoxia tolerance had a broad-sense heritability of 0.552 in adults and 0.433 in larvae. Larval and adult phenotypes were weakly correlate...
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#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Simon Werkhoven (ASU: Arizona State University)H-Index: 1
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
view all 3 authors...
Animals vary tremendously in their capacities to survive anoxia, and the mechanisms responsible are poorly understood. Adult Drosophila melanogaster are rapidly paralyzed and survive up to 12 h of ...
2 CitationsSource
#1Mathias V. Ravn (AU: Aarhus University)H-Index: 1
#2Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
Last. Johannes Overgaard (AU: Aarhus University)H-Index: 40
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ABSTRACT When exposed to anoxia, insects rapidly go into a hypometabolic coma from which they can recover when exposed to normoxia again. However, prolonged anoxic bouts eventually lead to death in most insects, although some species are surprisingly tolerant. Anoxia challenges ATP, ion, pH and water homeostasis, but it is not clear how fast and to what degree each of these parameters is disrupted during anoxia, nor how quickly they recover. Further, it has not been investigated which disruption...
2 CitationsSource
#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Mads Kuhlmann Andersen (AU: Aarhus University)H-Index: 8
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
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ABSTRACT Oxygen limitation plays a key role in many pathologies; yet, we still lack a fundamental understanding of the mechanisms responsible for variation in anoxia tolerance. Most vertebrate studies suggest that anoxia tolerance involves the ability to maintain cellular ATP despite the loss of aerobic metabolism. However, insects such as adult Drosophila melanogaster are able to survive long periods of anoxia (LT 50 : ∼8 h) in a hypo-energetic state characterized by low [ATP]. In this study, w...
8 CitationsSource
#1James C. Sargent (ASU: Arizona State University)
#2Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
view all 3 authors...
Cell death occurring from anoxia is considered to be the cause of many human diseases such as heart attack and stroke. Though much is known about the cause of anoxia in such conditions, we still ha...
#1Ying Wang (ASU: Arizona State University)H-Index: 14
#2Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
view all 6 authors...
ABSTRACT Environmental changes during development have long-term effects on adult phenotypes in diverse organisms. Some of the effects play important roles in helping organisms adapt to different environments, such as insect polymorphism. Others, especially those resulting from an adverse developmental environment, have a negative effect on adult health and fitness. However, recent studies have shown that those phenotypes influenced by early environmental adversity have adaptive value under cert...
23 CitationsSource
#1Jon F. HarrisonH-Index: 42
#2Milad ManouchehH-Index: 1
Last. Jacob B. CampbellH-Index: 4
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In general, insects respond to hypoxia by increasing ventilation frequency, as seen in most other animals. Higher body temperatures usually also increase ventilation rates, likely due to increases in metabolic rates. In ectothermic air-breathing vertebrates, body temperatures and hypoxia tend to interact significantly, with an increasing responsiveness of ventilation to hypoxia at higher temperatures. Here, we tested whether the same is true in insects, using the Madagascar hissing cockroach, Gr...
2 CitationsSource
#1Jacob B. Campbell (ASU: Arizona State University)H-Index: 4
#2Rachna Nath (ASU: Arizona State University)H-Index: 2
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
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Abstract Honey bees and other pollinators are exposed to fungicides that act by inhibiting fungal mitochondria. Here we test whether a common fungicide (Pristine®) inhibits the function of mitochondria of honeybees, and whether consumption of ecologically-realistic concentrations can cause negative effects on the mitochondria of flight muscles, or the capability for flight, as judged by CO2 emission rates and thorax temperatures during flight. Direct exposure of mitochondria to Pristine® levels ...
16 CitationsSource
#1Viviane Callier (ASU: Arizona State University)H-Index: 11
#2Steven C. Hand (LSU: Louisiana State University)H-Index: 37
Last. Jon F. Harrison (ASU: Arizona State University)H-Index: 42
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ABSTRACT Holometabolous insects undergo dramatic morphological and physiological changes during ontogeny. In particular, the larvae of many holometabolous insects are specialized to feed in soil, water or dung, inside plant structures, or inside other organisms as parasites where they may commonly experience hypoxia or anoxia. In contrast, holometabolous adults usually are winged and live with access to air. Here, we show that larval Drosophila melanogaster experience severe hypoxia in their nor...
37 CitationsSource
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