Ainara Estanga
Mayo Clinic
Publications 29
#1Mikel TaintaH-Index: 4
#2Maria de ArribaH-Index: 1
Last.Pablo Martinez-LageH-Index: 22
view all 13 authors...
#1Yaakov Stern (Columbia University)H-Index: 127
#2Gaël Chételat (French Institute of Health and Medical Research)H-Index: 55
Last.Eero Vuoksimaa (UH: University of Helsinki)H-Index: 18
view all 26 authors...
2 CitationsSource
#1Yaakov Stern (Columbia University)H-Index: 127
#2Eider M. Arenaza-Urquijo (Mayo Clinic)H-Index: 19
Last.Anita C. van LoenhoudH-Index: 2
view all 34 authors...
Abstract Several concepts, which in the aggregate get might be used to account for "resilience" against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been an attempt to arrive at consensus on the definition of these concepts. Furthermore, there has been confusion regarding the measurement of these construct...
44 CitationsSource
#1Alle Meije Wink (VU: VU University Amsterdam)H-Index: 22
#2Betty M. Tijms (VU: VU University Amsterdam)H-Index: 17
Last.Ernesto Sanz-Arigita (University of Bordeaux)H-Index: 1
view all 15 authors...
Introduction: Amyloid plaque deposition in the brain is an early pathological change in Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying an apolipoprotein (APOE)-e4 allele is a genetic risk for AD, associated with increased amyloid deposition. We studied whether APOE-e4 carriership is associated with EC disruptions in cognit...
1 CitationsSource
#1Mirian Ecay-TorresH-Index: 4
#2Ainara EstangaH-Index: 11
Last.Pablo Martinez-LageH-Index: 22
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Objective To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. Method Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE ...
2 CitationsSource
#1Isabelle Bos (UM: Maastricht University)H-Index: 4
#2Stephanie J.B. Vos (UM: Maastricht University)H-Index: 13
Last.Pieter Jelle Visser (UM: Maastricht University)H-Index: 49
view all 25 authors...
We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer’s disease Neuroimaging Initiative. All individuals were aged above 40, had Aβ status and neuropsychological data available. Linear mixed models were used to assess the associations of Aβ...
3 CitationsSource
#1Victor Montal (Autonomous University of Barcelona)H-Index: 7
#2Eduard Vilaplana (Autonomous University of Barcelona)H-Index: 9
Last.Juan Fortea (Autonomous University of Barcelona)H-Index: 28
view all 30 authors...
Abstract Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N=220; stage 1, N=25; and stag...
14 CitationsSource
#1Karmele López-de-Ipiña (UPV/EHU: University of the Basque Country)H-Index: 11
#2U. Martinez-de-Lizarduy (UPV/EHU: University of the Basque Country)H-Index: 2
Last.Marcos Faundez-ZanuyH-Index: 28
view all 8 authors...
The so-called Mild Cognitive Impairment (MCI) or cognitive loss appears in a previous stage before Alzheimer’s Disease (AD), but it does not seem sufficiently severe to interfere in independent abilities of daily life, so it usually does not receive an appropriate diagnosis. Its detection is a challenging issue to be addressed by medical specialists. This work presents a novel proposal based on automatic analysis of speech and disfluencies aimed at supporting MCI diagnosis. The approach includes...
2 CitationsSource