Malgorzata Grosbart
Erasmus University Medical Center
Replication protein ADNA repairMolecular biologyGeneticsBiology
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Publications 2
#1Humberto Sanchez (Erasmus University Medical Center)H-Index: 7
#2Maarten W. Paul (Erasmus University Medical Center)H-Index: 1
Last. Wyman Clair (Erasmus University Medical Center)H-Index: 42
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textabstractThe tumor suppressor BRCA2 is a large multifunctional protein mutated in 50-60% of familial breast cancers. BRCA2 interacts with many partners and includes multiple regions with potentially disordered structure. In homology directed DNA repair BRCA2 delivers RAD51 to DNA resulting in removal of RPA and assembly of a RAD51 nucleoprotein filament. Dynamic rearrangements of BRCA2 likely drive this molecular hand-off initiating DNA strand exchange. We show human BRCA2 forms oligomers whi...
12 CitationsSource
#1Jun Hyun Kim (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 3
#2Malgorzata Grosbart (Erasmus University Medical Center)H-Index: 2
Last. John H.J. Petrini (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 54
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The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal levels. To delineate essential and non-essential Mre11 complex functions that are mediated by Nbs1, we used TALEN-based genome editing to derive Nbs1 mutant mice (Nbs1mid mice), which harbor mutations in the Mre11 interaction domain of Nbs1. Nbs1mid alleles th...
16 CitationsSource