Shaf Keshavjee
University Health Network
PathologyLungLung transplantationTransplantationMedicine
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Publications 802
#1Jay S. HanH-Index: 15
#2Azad MashariH-Index: 1
Last. Alex VeselyH-Index: 13
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#1Jordan J. Feld (UHN: University Health Network)H-Index: 48
#2Marcelo Cypel (UHN: University Health Network)H-Index: 33
Last. Mohamed A Zahoor (UHN: University Health Network)
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Summary Background An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). After transplantation from an infected donor, establishment of HCV infection in uninfected recipients is near-universal, with the requirement for post-transplant antiviral treatment. The aim of this study was to determine if antiviral drugs combined with an HCV entry blocker given before and for 7 days after transplant would be safe and reduce the likelihood of HCV infection in recipi...
#1Marc de Perrot (U of T: University of Toronto)H-Index: 51
#2Licun Wu (UHN: University Health Network)H-Index: 10
Last. B.C. John Cho (UHN: University Health Network)H-Index: 17
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Abstract Objective Cytotoxic CD8+ tumor infiltrating lymphocytes (TILs) can contribute to the benefit of hypofractionated radiation, but programmed cell death pathway (PD-1/PD-L1) may provide a mechanism of tumor immune escape. We therefore reviewed the impact of PD-1/PD-L1 and CD8+ TILs on survival after accelerated hypofractionated hemithoracic radiation followed by extrapleural pneumonectomy (EPP) for MPM. Methods 69 consecutive patients undergoing the protocol of Surgery for Mesothelioma Aft...
3 CitationsSource
#1Biniam Kidane (UM: University of Manitoba)H-Index: 8
#2Nithin Jacob (TGH: Toronto General Hospital)
Last. Thomas K. Waddell (TGH: Toronto General Hospital)H-Index: 53
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OBJECTIVES: Transfusion of blood products has been associated with increased risk of post-pneumonectomy respiratory failure. It is unclear whether intraoperative or postoperative transfusions confer a higher risk of respiratory failure. Our objective was to assess the role of transfusions in developing post-pneumonectomy respiratory failure. METHODS: We performed a retrospective cohort study using prospectively collected data on consecutive pneumonectomies between 2005 and 2015. Patient records ...
#1Ben Dunne (UHN: University Health Network)
#2Philippe Lemaître (UHN: University Health Network)
Last. Shaf Keshavjee (UHN: University Health Network)H-Index: 74
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#1A. Ali (TGH: Toronto General Hospital)H-Index: 1
#2Yui Watanabe (TGH: Toronto General Hospital)
Last. William E. Stansfield (UHN: University Health Network)H-Index: 6
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Abstract Background The use of a novel extracellular oxygen carrier (EOC) preservation additive known as HEMO2Life® has recently been shown to lead to superior preservation of different types of solid organs. The aims of our study were to investigate the effect of this EOC on extending lung preservation time and its mechanism of action. Methods Donor pigs were randomly allocated to 2 groups (n=6 / group): 1) 36h cold preservation 2) 36h cold preservation with 1g/L of EOC. The lungs were evaluate...
#1Aaron Wong (U of T: University of Toronto)
#2Ricardo Zamel (UHN: University Health Network)H-Index: 12
Last. Mingyao LiuH-Index: 72
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Introduction The ex vivo lung perfusion (EVLP) technique has been developed to assess the function of marginal donor lungs which has significantly increased donor lung utilisation. EVLP has also been explored as a platform for donor lung repair through injury specific treatments such as antibiotics or fibrinolytics. We hypothesised that actively expressed pathways shared between transplantation and EVLP may reveal common mechanisms of injury and potential therapeutic targets for lung repair prio...
#1B. Renaud-Picard (TGH: Toronto General Hospital)
Last. Tereza MartinuH-Index: 19
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Purpose The long-term survival after a lung transplantation remains limited by Chronic Lung Allograft Dysfunction (CLAD), which includes two main phenotypes: bronchiolitis obliterans syndrome (BOS), characterized by airway fibrosis and obliteration, and restrictive allograft syndrome (RAS), presenting with parenchymal fibrosis (PF) and restriction (2019 ISHLT consensus). It has been noted that there can be overlap between these phenotypes. We aimed to detail and quantify pathological features of...
#1K. Halloran (U of A: University of Alberta)H-Index: 6
#2Michael ParkesH-Index: 3
Last. Philip F. Halloran (U of A: University of Alberta)H-Index: 2
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Diagnosing lung transplant rejection currently depends on histologic assessment of transbronchial biopsies (TBB) with limited reproducibility and considerable risk of complications. Mucosal biopsies are safer but not histologically interpretable. Microarray-based diagnostic systems for TBBs and other transplants suggest such systems could assess mucosal biopsies as well. We studied 243 mucosal biopsies from the third bronchial bifurcation (3BMBs) collected from seven centers and classified them ...