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Tatsuya Takemoto
University of Tokushima
42Publications
13H-index
1,025Citations
Publications 42
Newest
Published on May 10, 2019in Science 41.06
Daisuke Sugiura8
Estimated H-index: 8
(University of Tokushima),
Takumi Maruhashi6
Estimated H-index: 6
(University of Tokushima)
+ 4 AuthorsTaku Okazaki39
Estimated H-index: 39
(University of Tokushima)
Targeted blockade of PD-1 using checkpoint inhibitor immunotherapies can activate T cells to destroy tumors. PD-1 is believed to function mainly at the effector but not in the activation phase of T cell responses, yet how PD-1 function is restricted at the activation stage is currently unknown. Here we demonstrate that CD80 interacts with PD-L1 in cis on antigen presenting cells (APCs) to disrupt PD-L1/PD-1 binding. Subsequently, PD-L1 cannot engage PD-1 to inhibit T cell activation when APCs ex...
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Published on Jan 1, 2019in Animal Science Journal 1.40
Fuminori Tanihara9
Estimated H-index: 9
(University of Tokushima),
Maki Hirata1
Estimated H-index: 1
(University of Tokushima)
+ 6 AuthorsTakeshige Otoi30
Estimated H-index: 30
(University of Tokushima)
1 Citations Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Akihito Harada13
Estimated H-index: 13
(Kyushu University),
Kazumitsu Maehara14
Estimated H-index: 14
(Kyushu University)
+ 14 AuthorsJumpei Nogami5
Estimated H-index: 5
(Kyushu University)
Regulation of gene expression requires selective incorporation of histone H3 variant H3.3 into chromatin. Histone H3.3 has several subsidiary variants but their functions are unclear. Here we characterize the function of histone H3.3 sub-variant, H3mm7, which is expressed in skeletal muscle satellite cells. H3mm7 knockout mice demonstrate an essential role of H3mm7 in skeletal muscle regeneration. Chromatin analysis reveals that H3mm7 facilitates transcription by forming an open chromatin struct...
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Published on Oct 23, 2018in PLOS ONE 2.77
Fuminori Tanihara9
Estimated H-index: 9
(University of Tokushima),
Maki Hirata1
Estimated H-index: 1
(University of Tokushima)
+ 6 AuthorsTakeshige Otoi30
Estimated H-index: 30
(University of Tokushima)
TP53 (which encodes p53) is one of the most frequently mutated genes in cancers. In this study, we generated TP53-mutant pigs by gene editing via electroporation of the Cas9 protein (GEEP), a process that involves introducing the Cas9 protein and single-guide RNA (sgRNA) targeting exon 3 and intron 4 of TP53 into in vitro-fertilized zygotes. Zygotes modified by the sgRNAs were transferred to recipients, two of which gave birth to a total of 11 piglets. Of those 11 piglets, 9 survived. Molecular ...
1 Citations Source Cite
Published on Apr 1, 2018in Reproduction in Domestic Animals 1.42
Kazumasa Nishio2
Estimated H-index: 2
(University of Tokushima),
Fuminori Tanihara9
Estimated H-index: 9
(University of Tokushima)
+ 5 AuthorsTakeshige Otoi30
Estimated H-index: 30
(University of Tokushima)
Contents This study was conducted to determine suitable conditions for an experimental method in which the CRISPR/Cas9 system is introduced into in vitro-produced porcine zygotes by electroporation. In the first experiment, when putative zygotes derived from in vitro fertilization (IVF) were electroporated by either unipolar or bipolar pulses, keeping the voltage, pulse duration and pulse number fixed at 30 V/mm, 1 msec and five repeats, respectively, the rate of blastocyst formation from zygote...
2 Citations Source Cite
Published on Oct 31, 2017
Sayumi Fujimori1
Estimated H-index: 1
,
Izumi Ohigashi19
Estimated H-index: 19
+ 2 AuthorsShinji Takada45
Estimated H-index: 45
Published on Apr 1, 2017in Nature Communications 12.35
Muhammad Myn Uddin1
Estimated H-index: 1
,
Izumi Ohigashi19
Estimated H-index: 19
+ 9 AuthorsTatsuya Takemoto13
Estimated H-index: 13
Foxn1 is involved in thymic epithelial cell (TEC) and CD8+ T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.
7 Citations Source Cite
Published on Mar 1, 2017in Acta Veterinaria Hungarica 1.04
Katsutoshi Nishio1
Estimated H-index: 1
,
Mado Yamazaki1
Estimated H-index: 1
+ 6 AuthorsTakeshige Otoi30
Estimated H-index: 30
The present study was conducted to clarify whether the meiotic stage of porcine oocytes has the highest sensitivity to hyperthermia during in vitro maturation by evaluating meiotic competence and DNA damage. Oocytes were exposed to 41 °C for 12 h at various intervals during 48 h of maturation culture. When the oocytes were exposed to 41 °C from 12 to 24 h of the maturation culture, the proportion of oocytes reaching metaphase II (MII) decreased as compared to the control oocytes cultured at 38.5...
1 Citations Source Cite
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