Rajiv Radhakrishnan
Yale University
Publications 62
#1Mohini Ranganathan (Yale University)H-Index: 22
#2Joao P. De Aquino (Yale University)H-Index: 1
Last.Deepak Cyril D’Souza (Yale University)H-Index: 19
view all 7 authors...
Rationale The catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.
#1M. Di Forti ('KCL': King's College London)H-Index: 34
#2Emma Dempster (University of Exeter)H-Index: 26
Last.Robin M. Murrayand ('KCL': King's College London)H-Index: 143
view all 12 authors...
#1Catherine Orr (Swinburne University of Technology)H-Index: 12
#2Philip A. Spechler (UVM: University of Vermont)H-Index: 7
Last.Arun L.W. Bokde (Trinity College, Dublin)H-Index: 41
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Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human a...
#1Deepak Cyril D'Souza (Yale University)H-Index: 25
#2Jose Cortes-Briones (Yale University)H-Index: 9
Last.Aarti Gupta (Yale University)H-Index: 2
view all 17 authors...
Summary Background Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of cannabis that causes significant clinical and functional impairment. There are no approved pharmacological treatments for cannabis use disorder. One approach is to potentiate endocannabinoid signalling by inhibiting fatty acid amide hydrolase (FAAH), the enzyme that degrades the endocannabinoid anandamide. We aimed to test the efficacy and safety of the FAAH-inhi...