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Rajiv Radhakrishnan
Yale University
PsychiatryPsychologyClinical psychologyMedicineSchizophrenia
64Publications
14H-index
769Citations
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Publications 69
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#1Suhas Ganesh (Yale University)H-Index: 1
#2Jose Cortes-Briones (Yale University)H-Index: 10
Last. Deepak Cyril D'Souza (Yale University)H-Index: 35
view all 6 authors...
INTRODUCTION: There is increasing interest in the relationship between cannabinoids and psychosis. While individual human laboratory studies have been critical in demonstrating that cannabinoids (e.g., delta-9-tetrahydrocannabinol [THC]) can induce acute transient psychosis-like effects in healthy human volunteers, combining data from multiple studies offers a fine-grained view of these effects. METHODS: THC-induced psychosis-relevant effects were examined using a data-repository of 10 double-bl...
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#1Guy Hindley ('KCL': King's College London)
#2Katherine BeckH-Index: 11
Last. Oliver D. HowesH-Index: 52
view all 10 authors...
Summary Background Approximately 188 million people use cannabis yearly worldwide, and it has recently been legalised in 11 US states, Canada, and Uruguay for recreational use. The potential for increased cannabis use highlights the need to better understand its risks, including the acute induction of psychotic and other psychiatric symptoms. We aimed to investigate the effect of the cannabis constituent Δ9-tetrahydrocannabinol (THC) alone and in combination with cannabidiol (CBD) compared with ...
1 CitationsSource
#1Mohini Ranganathan (Yale University)H-Index: 24
#2Mohamed Rahman (St. Joseph Hospital)
Last. Thalachallour Mohanakumar (St. Joseph Hospital)H-Index: 2
view all 8 authors...
There is considerable interest in identifying peripheral biomarkers of schizophrenia. Exosomes are a class of extracellular vesicles that are secreted into intracellular space and cross the blood brain barrier with their contents intact. Exosomes and their cargo, including lipids, proteins and genetic materials can be assayed peripherally. Studies of circulating exosomes have led to a greater understanding of their role as markers and mediators of pathology in neurodegenerative disorders, but th...
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#1Rajiv Radhakrishnan (Yale University)H-Index: 14
#2David Matuskey (Yale University)H-Index: 16
Last. Deepak Cyril D'Souza (Yale University)H-Index: 35
view all 12 authors...
Abstract While 5-HT6 receptor is a potential therapeutic target for cognitive impairment in schizophrenia (SCZ), in vivo 5-HT6 receptor availability following antipsychotic treatment has not been examined to-date. We examined the availability of 5-HT6 and 5-HT2A receptors following treatment with olanzapine, risperidone, aripiprazole and quetiapine in male patients with SCZ vs unmedicated age-matched healthy male controls (HC) using positron emission tomography (PET) imaging with [11C]GSK215083....
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#1A. Bhat (UW: University of Washington)
#2B Ramakrishna Goud (St. John's Medical College)H-Index: 2
Last. Krishnamachari Srinivasan (St. John's Medical College)H-Index: 15
view all 6 authors...
Major Depressive Disorder (MDD) is associated with low rates of treatment and medication non-adherence, more so in low- and middle-income countries (LMICs). Mobile mental health (mHealth) interventions offer promise as a tool to address these problems. However, the feasibility and acceptability of mHealth interventions among rural women in LMICs is unknown. We examined barriers to accessing mental health treatment, reasons for non-adherence, and attitudes towards mHealth solutions among women wi...
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#1Mohini Ranganathan (Yale University)H-Index: 24
#2Joao P. De Aquino (Yale University)H-Index: 1
Last. Deepak Cyril D'Souza (Yale University)H-Index: 35
view all 7 authors...
Rationale The catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.
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#1Rajiv RadhakrishnanH-Index: 14
#2Sinan GuloksuzH-Index: 17
Last. Edwin J. C. G. van den OordH-Index: 123
view all 11 authors...
BACKGROUND: Evidence suggests that cannabis use, childhood adversity, and urbanicity, in interaction with proxy measures of genetic risk, may facilitate onset of psychosis in the sense of early affective dysregulation becoming 'complicated' by, first, attenuated psychosis and, eventually, full-blown psychotic symptoms. METHODS: Data were derived from three waves of the second Netherlands Mental Health Survey and Incidence Study (NEMESIS-2). The impact of environmental risk factors (cannabis use,...
5 CitationsSource
#1Ulrich Reininghaus (UM: Maastricht University)H-Index: 23
Last. Edwin J. C. G. van den OordH-Index: 123
view all 12 authors...
BACKGROUND: The jumping to conclusions (JTC) reasoning bias and decreased working memory performance (WMP) are associated with psychosis, but associations with affective disturbances (i.e. depression, anxiety, mania) remain inconclusive. Recent findings also suggest a transdiagnostic phenotype of co-occurring affective disturbances and psychotic experiences (PEs). This study investigated whether JTC bias and decreased WMP are associated with co-occurring affective disturbances and PEs. METHODS: ...
1 CitationsSource
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