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Juha Hartikainen
University of Eastern Finland
CardiologyAtrial fibrillationAnesthesiaDiabetes mellitusMedicine
189Publications
37H-index
6,275Citations
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Publications 252
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#1Johanna E. Lähteenvuo (University of Eastern Finland)H-Index: 5
#1Lähteenvuo Johanna (University of Eastern Finland)
Last. Nihay Laham-Karam (University of Eastern Finland)H-Index: 4
view all 15 authors...
Abstract VEGF-B gene therapy is a promising proangiogenic treatment for ischemic heart disease, but unexpectedly, we found that high doses of VEGF-B promote ventricular arrhythmias (VA).VEGF-B knockout, αMHC-VEGF-B transgenic mice, and pigs transduced intramyocardially with adenoviral (Ad)VEGF- B186 were studied.Immunostaining showed a 2-fold increase in the number of nerves (76 vs.39 in controls, nerves/field,p
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#1Andrew Ladwiniec (Glenfield Hospital)H-Index: 1
#2Simon WalshH-Index: 17
Last. Ian B. A. MenownH-Index: 12
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AIMS: We investigated the association between the use and findings of IVUS with clinical outcomes in the PCI arm of a randomised trial of LMS PCI. METHODS AND RESULTS: The NOBLE trial randomised patients with LMS disease to treatment by PCI or CABG. Of 603 patients treated by PCI, 435(72%) underwent post-PCI IVUS assessment of which 224 were analysed in a core-laboratory. At 5 years, the composite of MACCE were 18.9% if post-PCI IVUS was performed vs. 25.0% if not (p=0.45, after adjustment). Ove...
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#1Maunu Nissinen (University of Eastern Finland)H-Index: 1
#2Joonas Lehto (TYKS: Turku University Hospital)H-Index: 2
Last. Juha Hartikainen (University of Eastern Finland)H-Index: 37
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BACKGROUND: Preoperative permanent atrial fibrillation (AF) is associated with impaired outcome after surgical aortic valve replacement (SAVR). The impact of preoperative paroxysmal AF, however, has remained elusive. PURPOSE: We assessed the impact of preoperative paroxysmal AF on outcome in patients undergoing SAVR with bioprosthesis. METHODS: A total of 666 patients undergoing isolated AVR with a bioprosthesis were included. Survival data was obtained from the national registry Statistics Finl...
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#1Maarit Jaana Korhonen (Monash University)H-Index: 22
#2Jaana Pentti (UH: University of Helsinki)H-Index: 57
Last. Jussi Vahtera (UTU: University of Turku)H-Index: 86
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Background Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions. We evaluated whether lifestyle factors change in ...
2 CitationsSource
#1Joonas Lehto (TYKS: Turku University Hospital)H-Index: 2
#2Jarmo Gunn (TYKS: Turku University Hospital)H-Index: 11
Last. Tuomas Kiviniemi (Brigham and Women's Hospital)H-Index: 16
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Abstract Objectives Postpericardiotomy syndrome (PPS) is a relatively common complication after cardiac surgery. However, long-term follow-up data on the adverse events and mortality of PPS patients requiring invasive interventions are scarce. Methods We sought to assess the occurrence of mortality, new-onset atrial fibrillation (AF), cerebrovascular events, and major bleeds in PPS patients requiring medical attention in a combination database of 671 patients undergoing isolated surgical aortic ...
3 CitationsSource
#1Indulis KumsarsH-Index: 15
#2Niels Ramsing Holm (Aarhus University Hospital)H-Index: 24
Last. Jørgen Fr Lassen (Aarhus University Hospital)H-Index: 56
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Background It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation. Methods The study was a randomised, superiority trial. Enrolment required a SB≥2.75 mm, ≥50% diameter stenosis in both vessels...
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#1Niels Ramsing Holm (Aarhus University Hospital)H-Index: 24
#2Timo H. Mäkikallio (OUH: Oulu University Hospital)H-Index: 53
Last. Ves AnttilaH-Index: 1
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Summary Background Percutaneous coronary intervention (PCI) is increasingly used in revascularisation of patients with left main coronary artery disease in place of the standard treatment, coronary artery bypass grafting (CABG). The NOBLE trial aimed to evaluate whether PCI was non-inferior to CABG in the treatment of left main coronary artery disease and reported outcomes after a median follow-up of 3·1 years. We now report updated 5-year outcomes of the trial. Methods The prospective, randomis...
14 CitationsSource
#1Jari Heiskanen (University of Eastern Finland)H-Index: 1
#2Juha Hartikainen (University of Eastern Finland)H-Index: 37
Last. Anna-Maija Tolppanen (University of Eastern Finland)H-Index: 24
view all 7 authors...
Aims We studied the purchases of medical therapy recommended for coronary artery disease patients before and after elective revascularisation (percutaneous coronary intervention (PCI) or coronary bypass grafting (CABG)).
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#2Alfonso MartínH-Index: 8
Last. José CarbajosaH-Index: 1
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Introduction: Vernakalant is a relatively atrial-selective antiarrhythmic agent for conversion of recent-onset atrial fibrillation (AF). SPECTRUM was a post-authorisation safety study of vernakalan...
#1E.-S Valiaho (University of Eastern Finland)
#2Pekka Kuoppa (University of Eastern Finland)H-Index: 3
Last. Juha Hartikainen (University of Eastern Finland)H-Index: 37
view all 11 authors...
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