Match!
Carol A. Kruse
University of California, Los Angeles
105Publications
24H-index
2,044Citations
Publications 104
Newest
#1Jianxun SongH-Index: 20
#2Adam W. MaillouxH-Index: 7
Last.Zhenzhen LiuH-Index: 7
view all 33 authors...
#1Kei Hiraoka (UCLA: University of California, Los Angeles)H-Index: 11
#2Akihito Inagaki (UM: University of Miami)H-Index: 7
Last.Noriyuki KasaharaH-Index: 38
view all 15 authors...
12 CitationsSource
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. Jadus (University of California, Berkeley)H-Index: 24
view all 7 authors...
ABSTRACTObjective: Temozolomide (TMZ) improves Glioblastoma Multiforme (GBM) patient survival. The invasive behavior of the glioma cells is the cause of GBM relapse. The glioma BK ion channel (gBK) may provide glioma cells with a mechanism to invade surrounding tissue. gBK contains epitopes that cytolytic T lymphocytes (CTLs) can recognize and kill glioma cells. Fascin-1 is an actin crosslinking molecule that supports microvilli; these membrane protrusions provide a physical defense against CTLs...
1 CitationsSource
#1Carol A. Kruse (UCLA: University of California, Los Angeles)H-Index: 24
#2Carlos A. Pardo (Johns Hopkins University)H-Index: 47
Last.Gary W. Mathern (UCLA: University of California, Los Angeles)H-Index: 61
view all 54 authors...
1 CitationsSource
#1Richard G. EversonH-Index: 11
#2Joseph P. AntoniosH-Index: 7
Last.Robert M. PrinsH-Index: 33
view all 12 authors...
Immunotherapy is an ideal treatment modality to specifically target the diffusely infiltrative tumor cells of malignant gliomas while sparing the normal brain parenchyma. However, progress in the development of these therapies for glioblastoma has been slow due to the lack of immunogenic antigen targets that are expressed uniformly and selectively by gliomas.We utilized human glioblastoma cell cultures to induce expression of New York-esophageal squamous cell carcinoma (NY-ESO-1) following in vi...
21 CitationsSource
#1Geoffrey C. Owens (UCLA: University of California, Los Angeles)H-Index: 5
#2Kate L. Erickson (UCLA: University of California, Los Angeles)H-Index: 4
Last.Carol A. Kruse (UCLA: University of California, Los Angeles)H-Index: 24
view all 10 authors...
Background Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum. Perivascular cuffing and clusters of T cells in the affected cortical hemisphere are indicative of an active cellular immune response.
10 CitationsSource
#1Michelle J. Hickey (UCLA: University of California, Los Angeles)H-Index: 9
#2Horacio Soto (UCLA: University of California, Los Angeles)H-Index: 19
Last.Carol A. Kruse (UCLA: University of California, Los Angeles)H-Index: 24
view all 10 authors...
In a Phase 1 dose escalation study we evaluated the safety, feasibility, toxicity, and survival of patients treated with allogeneic cytotoxic T lymphocytes and recombinant IL-2 (alloCTL, rIL-2) infusion administered to the resection cavity of patients with recurrent glioma (WHO grade III or IV). AlloCTL are generated when gamma-irradiated lymphoblasts from the brain tumor patient stimulate the proliferation of peripheral blood mononuclear cells (PBMC) isolated from an HLA-disparate healthy donor...
Source
#1Yuki Kato (UCLA: University of California, Los Angeles)H-Index: 2
#2Michelle J. Hickey (UCLA: University of California, Los Angeles)H-Index: 9
Last.Noriyuki KasaharaH-Index: 38
view all 9 authors...
Source
#1Kate L. Erickson (UCLA: University of California, Los Angeles)H-Index: 4
#2Michelle J. Hickey (UCLA: University of California, Los Angeles)H-Index: 9
Last.Carol A. Kruse (UCLA: University of California, Los Angeles)H-Index: 24
view all 9 authors...
We report a novel adaptation of the Radial Monolayer Cell Migration assay, first reported to measure the radial migration of adherent tumor cells on extracellular matrix proteins, for measuring the motility of fluorescently-labeled, non-adherent human or murine effector immune cells. This technique employs a stainless steel manifold and 10-well Teflon slide to focally deposit non-adherent T cells into wells prepared with either confluent tumor cell monolayers or extracellular matrix proteins. Li...
Source
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. JadusH-Index: 24
view all 9 authors...
Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting lymphocyte cytotoxicity. Microvilli and filopodia are supported by actin filaments cross-linked by fascin. Fascin-1 was genetically silenced within human U251 glioma cells; these knock-down glioma cells lost their microvilli/filopodia. The doubling time of these fascin-1 knock-down cells was doubled that of shRNA control U251 cells. Fascin-1 knoc...
7 Citations
12345678910