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Vedanta Mehta
University College London
25Publications
8H-index
248Citations
Publications 25
Newest
#1Kristen J. Bubb (Kolling Institute of Medical Research)H-Index: 11
#2Aisah A. Aubdool (QMUL: Queen Mary University of London)H-Index: 14
Last.Adrian J. Hobbs (QMUL: Queen Mary University of London)H-Index: 49
view all 11 authors...
Background: Angiogenesis and vascular remodeling are complementary, innate responses to ischemic cardiovascular events, including peripheral artery disease and myocardial infarction, which restore ...
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#1Marwa Mahmoud (UCL: University College London)H-Index: 11
#2Ian M. Evans (UCL: University College London)H-Index: 16
Last.Ian Zachary (UCL: University College London)H-Index: 45
view all 6 authors...
Neuropilin 1 (NRP1) is important for neuronal and cardiovascular development due to its role in conveying class 3 semaphorin and vascular endothelial growth factor signaling, respectively. NRP1 is ...
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#1Vedanta Mehta (UCL: University College London)H-Index: 8
#2Laura Fields (UCL: University College London)H-Index: 2
Last.Ian Zachary (UCL: University College London)H-Index: 45
view all 8 authors...
Objective— NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism for regulating angiogenesis, but the role of NRP1 proteolysis and the NRP1 species generated by cleavage in endothelial cells is not known. To characterize NRP1 proteolytic cleavage in endothelial cells, determine the mechanism, and investigate th...
2 CitationsSource
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#1Aisah A. Aubdool (QMUL: Queen Mary University of London)H-Index: 14
#2Kristen J. Bubb (QMUL: Queen Mary University of London)H-Index: 11
Last.Adrian J. Hobbs (QMUL: Queen Mary University of London)H-Index: 49
view all 9 authors...
Introduction: Angiogenesis and vascular remodelling are complementary, innate responses to ischaemic cardiovascular events that restore tissue blood supply and oxygenation; the endothelium plays a critical function in these intrinsic protective processes. We have recently established C-type natriuretic peptide (CNP) as a fundamental endothelial signalling species that coordinates vascular homeostasis. Herein, we define a central (patho)physiological role for CNP in angiogenesis and vascular remo...
#1A.M. Swanson (UCL: University College London)H-Index: 2
#2Vedanta Mehta (UCL: University College London)H-Index: 8
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 11 authors...
Fetal growth restriction (FGR) is a common and potentially severe pregnancy complication. Currently there is no treatment available. The guinea pig is an attractive model of human pregnancy as placentation is morphologically very similar between the species. Nutrient restriction of the dam creates growth-restricted fetuses while leaving an intact uteroplacental circulation, vital for evaluating novel therapies for FGR. Growth-restricted fetuses were generated by feeding Dunkin Hartley guinea pig...
5 CitationsSource
#1Vedanta Mehta (UCL: University College London)H-Index: 8
#2Keren Ofir (UCL: University College London)H-Index: 1
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 11 authors...
Our study aimed to target adenoviral gene therapy to the uteroplacental circulation of pregnant guinea pigs in order to develop a novel therapy for fetal growth restriction. Four methods of delivery of an adenovirus encoding β-galactosidase (Ad.LacZ) were evaluated: intravascular injection using phosphate-buffered saline (PBS) into (1) uterine artery (UtA) or (2) internal iliac artery or external administration in (3) PBS or (4) pluronic F-127 gel (Sigma Aldrich). Postmortem examination was perf...
10 CitationsSource
#1Caroline Pellet-Many (UCL: University College London)H-Index: 10
#2Vedanta Mehta (UCL: University College London)H-Index: 8
Last.Ian Zachary (UCL: University College London)H-Index: 45
view all 8 authors...
Aims Neuropilins 1 and 2 (NRP1 and NRP2) play crucial roles in endothelial cell migration contributing to angiogenesis and vascular development. Both NRPs are also expressed by cultured vascular smooth muscle cells (VSMCs) and are implicated in VSMC migration stimulated by PDGF-BB, but it is unknown whether NRPs are relevant for VSMC function in vivo . We investigated the role of NRPs in the rat carotid balloon injury model, in which endothelial denudation and arterial stretch induce neointimal ...
14 CitationsSource
#1Dj Carr (UCL: University College London)H-Index: 8
#2Vedanta Mehta (UCL: University College London)H-Index: 8
Last.Anna L. David (UCL: University College London)H-Index: 30
view all 4 authors...
In this chapter, we describe a safe and effective approach to achieve local VEGF gene transfer to the uterine arteries in pregnant sheep using direct injection of viral vectors into the uterine arteries. This approach resulted in improved fetal growth in growth-restricted pregnancies. Adenoviral vectors encoding VEGF-A165 or a reporter gene β-galactosidase were dissolved in 10 mL normal saline shortly before administration. A midline laparotomy was performed and the course of the uterine artery ...
1 CitationsSource
#1Vedanta MehtaH-Index: 8
#2K Abi-NaderH-Index: 5
Last.Anna L. DavidH-Index: 30
view all 11 authors...
The normal development of the uteroplacental circulation in pregnancy depends on angiogenic and vasodilatory factors such as vascular endothelial growth factor (VEGF). Reduced uterine artery blood flow (UABF) is a common cause of fetal growth restriction; abnormalities in angiogenic factors are implicated. Previously we showed that adenovirus (Ad)-mediated VEGF-A165 expression in the pregnant sheep uterine artery (UtA) increased nitric oxide synthase (NOS) expression, altered vascular reactivity...
22 CitationsSource
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