Annika Braun
University Hospital Heidelberg
Publications 24
#1Wolfgang StremmelH-Index: 75
#2Robert EhehaltH-Index: 31
Last.Annika BraunH-Index: 10
view all 7 authors...
The colonic mucus serves a first barrier towards invasion of commensal bacteria in stools to prevent inflammation. One essential component of intestinal mucus is phosphatidylcholine (PC) which represe
20 CitationsSource
#1Wolfgang StremmelH-Index: 75
#2Robert EhehaltH-Index: 31
view all 42 authors...
#1Wolfgang StremmelH-Index: 75
#2Robert EhehaltH-Index: 31
view all 42 authors...
#1Annika BraunH-Index: 10
#2Wolfgang StremmelH-Index: 75
Last.Robert EhehaltH-Index: 31
view all 3 authors...
#1Annika Braun (University Hospital Heidelberg)H-Index: 10
#2Ulrike Schönfeld (University Hospital Heidelberg)H-Index: 1
Last.Robert Ehehalt (University Hospital Heidelberg)H-Index: 31
view all 13 authors...
Purpose There is increasing evidence that a defect of the gastrointestinal mucosal barrier is important for the development of inflammatory bowel diseases (IBD). The hydrophobicity of the colonic mucosal surface is a measure of its resistance to luminal antigens, e.g. of bacterial origin. Therefore, the purpose of this study was to determine this parameter in patients suffering from IBD.
8 CitationsSource
Importance of the field: As the pathogenesis of ulcerative colitis (UC) is unknown, a causative therapy is lacking. Therefore, some UC patients suffer from disease activity despite symptomatic anti-inflammatory treatment strategies. We claim that reduction of phosphatidylcholine (PC) in colonic mucus impairs the mucosal barrier and, thus, causes attacks of the commensal bacterial flora to induce colitis. Thus, mucus PC substitution could provide a causal therapy for UC.Areas covered in this revi...
14 CitationsSource
Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recently shown that mucus from UC patients has a decreased phosphatidylcholine (PC) content, while clinical trials revealed that therapeutic addition of PC to the colonic mucus alleviated the inflammatory activity. The mechanisms behind this are still unclear. We hypothesized that PC has at least two possible functions in the intestine: First, it establi...
34 CitationsSource
#1Robert Ehehalt (University Hospital Heidelberg)H-Index: 31
#2Annika Braun (University Hospital Heidelberg)H-Index: 10
Last.Wolfgang Stremmel (University Hospital Heidelberg)H-Index: 75
view all 5 authors...
Phosphatidylcholine (PC) is an important constituent of the gastrointestinal tract. PC molecules are not only important in intestinal cell membranes but also receiving increasing attention as protective agents in the gastrointestinal barrier. They are largely responsible for establishing the hydrophobic surface of the colon. Decreased phospholipids in colonic mucus could be linked to the pathogenesis of ulcerative colitis, a chronic inflammatory bowel disease. Clinical studies revealed that ther...
49 CitationsSource
#1Hannah SchneiderH-Index: 2
#2Irina TreedeH-Index: 3
Last.Robert EhehaltH-Index: 31
view all 6 authors...
#1Wolfgang Stremmel (University Hospital Heidelberg)H-Index: 75
#2Anja Hanemann (University Hospital Heidelberg)H-Index: 4
Last.Annika Braun (University Hospital Heidelberg)H-Index: 10
view all 5 authors...
Colonic mucus protects against attacks from bacteria in stool. One component of mucus is phosphatidylcholine (PC) which is thought to be arranged as continuous lamellar layer in the apical mucus and to be responsible for establishing a protective hydrophobic surface. This ‘intestinal surfactant’ plays a key role in mucosal defense. Thus, a defective PC layer contributes to the development of inflammation. Analysis of rectoscopically acquired mucus aliquots revealed a 70% decrease in PC content i...
28 CitationsSource