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Fátima Martel
University of Porto
EndocrinologyChemistryBiochemistryDiabetes mellitusBiology
167Publications
28H-index
2,780Citations
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Publications 172
Newest
#1Mafalda R. Couto (University of Montpellier)
#2Pedro Gonçalves (French Institute of Health and Medical Research)H-Index: 3
Last. Fátima Martel (University of Porto)H-Index: 28
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Abstract Inflammatory bowel disease (IBD) refers to a group of heterogeneous disorders associated with chronic inflammation of the gut, having a high rate of incidence in the world. In the present review, we will discuss the link between the short-chain fatty acids, especially butyrate (BT), produced by bacterial fermentation of dietary fiber, and IBD development. Current knowledge supports an anti-inflammatory role for BT and suggests that BT insufficiency may be involved in the pathogenesis of...
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#1Juliana Peixoto (University of Porto)
#2Gerardo Alvarez-Rivera (CSIC: Spanish National Research Council)H-Index: 9
Last. Elena Ibáñez (CSIC: Spanish National Research Council)H-Index: 56
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The antioxidant potential and phenolic profile of infusions prepared with cherry stems from different commercial brands were studied. The phenolic profile of each infusion was characterized by UHPLC-ESI-QTOF-MS and 44 phenolic compounds belonging to eight distinct classes (hydroxybenzoic acids, hydroxycinnamic acids, phenylpropanoic acids, flavan-3-ols, flavonols, flavanones, flavones and isoflavones) were tentatively identified. For the first time, salicylic acid was identified in cherry stem i...
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#1Fátima MartelH-Index: 28
#2Elisa KeatingH-Index: 17
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#1Nelson Andrade (University of Porto)H-Index: 2
#2Sara Andrade (University of Porto)H-Index: 5
Last. Fátima Martel (University of Porto)H-Index: 28
view all 8 authors...
Purpose Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenol chrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model.
4 CitationsSource
#1Joao NogueiraH-Index: 4
#1João NogueiraH-Index: 1
Last. Ana L. Daniel-da-SilvaH-Index: 22
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Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ĸ-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile,...
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#1Ana Catarina Barroso Macedo Barbosa (University of Porto)
#1Ana M. BarbosaH-Index: 1
Last. Fátima Martel (University of Porto)H-Index: 28
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Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark. The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in much higher rates of glucose uptake and glycolytic oxidation coupled with the production of lactic acid, even in the presence of oxygen. Consequently, cancer cells have higher glucose needs and thus display a higher sensitivity to glucose deprivation-induced death than normal cells. So, inhibitors of glucose uptake are po...
3 CitationsSource
#1Ana Tojal (University of Porto)
#2Catarina Neves (University of Porto)
Last. Elisa Keating (University of Porto)H-Index: 17
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Offspring of dams exposed to excess folic acid during the perigestational period have been shown by us to be predisposed to metabolic dysfunction revealed by hyperglycemia, glucose intolerance, increased insulin and decreased adiponectin in late adulthood. This work aims to characterize adipocyte phenotype and expression profile of genes in the regulation of lipid and glucose metabolism in visceral adipose tissue and in skeletal muscle. From mating until weaning, a recommended dose of folic acid...
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#1Cláudia Silva (University of Porto)H-Index: 34
#2Ana Correia-Branco (University of Porto)H-Index: 11
Last. Fátima Martel (University of Porto)H-Index: 28
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Abstract Cancer is a major cause of death in both developed and developing countries. Polyphenols, abundantly found in plants, possess many anticarcinogenic properties, including inhibition of cancer cell proliferation, tumor growth, angiogenesis, metastasis and inflammation, as well as pro-apoptotic effects. Our study aimed to investigate the effects of a complex of (+)-catechin with 2 lysines (Cat:Lys) on cancer and non-cancer cells. For this, the in vitro effects of Cat:Lys on the viability, ...
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#1Ana Correia-Branco (University of Porto)H-Index: 11
#2Elisa Keating (University of Porto)H-Index: 17
Last. Fátima Martel (University of Porto)H-Index: 28
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AbstractOur aim was to investigate the effect of some xenobiotics on placentation-related processes in an extravillous trophoblastic cell line (HTR-8/SVneo cells). Amphetamine, MDMA, theophylline, ...
3 CitationsSource
#1Nelson Andrade (University of Porto)H-Index: 2
#2Cláudia Marques (NOVA: Universidade Nova de Lisboa)H-Index: 11
Last. Fátima Martel (University of Porto)H-Index: 28
view all 10 authors...
Intake of fructose-containing sugars is epidemiological and experimentally linked to metabolic syndrome (MS). We recently verified that the dietary polyphenol chrysin was able to abolish some of the metabolic changes induced by fructose-feeding in the rat. Because the role of the intestine upon fructose-induced MS is poorly understood, we decided to investigate the influence of fructose, in vivo, on the intestinal environment and the ability of chrysin to interfere with the putative observed cha...
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