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Shuxia Li
University of Southern Denmark
HeritabilityDNA methylationGeneticsMedicineBiology
52Publications
11H-index
300Citations
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Publications 52
Newest
#1Dea Ravn (University of Southern Denmark)H-Index: 1
Last. Qihua Tan
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#1Shuxia Li (University of Southern Denmark)H-Index: 11
#2Jesper Lund (University of Southern Denmark)H-Index: 4
Last. Riccardo E. Marioni (Edin.: University of Edinburgh)H-Index: 46
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BACKGROUND: Large numbers of autosomal sites are found differentially methylated in the aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome content and X-inactivation (XCI) in females, this has not been explored for the X chromosome. METHODS: Using data from middle age to elderly individuals (age 55+ years) from two Danish cohorts of monozygotic twins and the Scottish Lothian Birth Cohort 1921, we conducted an X-chromosome-wide analysis of age-associated ...
1 CitationsSource
#1Jesper Lund (University of Southern Denmark)H-Index: 4
#2Shuxia Li (University of Southern Denmark)H-Index: 11
Last. Qihua Tan (University of Southern Denmark)H-Index: 34
view all 10 authors...
Overall or all-cause mortality is a key measure of health in a population. Multiple epigenome-wide association studies have been conducted on all-cause mortality with limited significant findings and low replication. In order to elucidate the co-regulated DNA methylation patterns associated with all-cause mortality, we conducted a weighted DNA methylation co-regulation network analysis on whole-blood samples of 1,425 older individuals from the Lothian Birth Cohorts of 1921 and 1936. Our network-...
Source
#1Jesper Lund (University of Southern Denmark)H-Index: 4
#2Shuxia Li (University of Southern Denmark)H-Index: 11
Last. Qihua Tan (University of Southern Denmark)H-Index: 34
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: The Y chromosome, a sex chromosome that only exists in males, has been ignored in traditional epigenetic association studies for multiple reasons. However, sex differences in aging-related phenotypes and mortality could suggest a critical role of the sex chromosomes in the aging process. We obtained blood-based DNA methylation data on the Y chromosome for 624 men from four cohorts and performed a chromosome-wide epigenetic association analysis to detect Y-linked CpGs differentially methylated ...
6 CitationsSource
#1Afsaneh Mohammadnejad (University of Southern Denmark)H-Index: 1
#2Shuxia Li (University of Southern Denmark)H-Index: 11
Last. Qihua Tan (University of Southern Denmark)H-Index: 34
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Abstract Electroacupuncture (EA) has been extensively considered as a tool for treating diseases and relieving various pains. However, understanding the molecular mechanisms underlying its effect is of high importance. In this study, we performed a weighted gene co-expression network analysis (WGCNA) on data collected from a microarray experiment to investigate the relationship underlying EA within three factors, time, frequency and tissue regions (periaqueductal grey (PAG) and spinal dorsal hor...
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#1Shuxia Li (University of Southern Denmark)H-Index: 11
#2Jesper Lund (University of Southern Denmark)H-Index: 4
Last. Qihua Tan (University of Southern Denmark)H-Index: 34
view all 11 authors...
BackgroundMultiple epigenetic association studies on human aging have been performed reporting large numbers of sites differentially methylated across ages on the autosomal chromosomes. The X-chromosome has been studied little, due to analytical difficulties in dealing with sex differences in X-chromosome content and X-inactivation in females. Based on large collections of genome-wide DNA methylation data on two Danish cohorts of identical twins (mean ages, 66 and 79 years) and the Lothian Birth...
Source
#1Qihua Tan (University of Southern Denmark)H-Index: 34
#2Hongmei Duan (UCPH: University of Copenhagen)H-Index: 3
Last. Shuxia Li (University of Southern Denmark)H-Index: 11
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Abstract Purpose Although moderate to high genetic contribution to blood pressure variation have been estimated in numerous studies, the genetic control over the longitudinal change in blood pressure has been less frequently investigated because of the requirement of longitudinal design. Methods Based on blood pressure data from a large-scale family-based longitudinal survey, we introduced hierarchical modeling of longitudinal family data in combination with fractional polynomials for fitting no...
1 CitationsSource
#1Haiping Duan (KI: Karolinska Institutet)H-Index: 7
#2Dongfeng Zhang (Qingdao University)H-Index: 20
Last. Chengxuan Qiu (KI: Karolinska Institutet)H-Index: 43
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OBJECTIVES: The heritability of age-related hearing loss has been studied mostly in developed countries. The authors aimed to estimate the heritability of better ear hearing level (BEHL), defined as hearing level of the better ear at a given frequency, and pure-tone averages at the middle (0.5, 1.0, and 2.0 kHz) and high (4.0, 8.0, and 12.5 kHz) frequencies among middle-aged and elderly Chinese twins, and to explore their genetic correlations. DESIGN: This population-based twin study included 22...
1 CitationsSource
#1Vibe Maria Jacobsen (University of Southern Denmark)H-Index: 1
#2Shuxia LiH-Index: 11
Last. Qihua Tan (University of Southern Denmark)H-Index: 34
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AbstractPolycystic ovarian syndrome (PCOS) is a complex disorder affecting up to 15–20% of reproductive women. PCOS has recently been investigated using genome-wide association studies revealing im...
3 CitationsSource
#1Jesper Lund (University of Southern Denmark)H-Index: 4
#2Shuxia Li (University of Southern Denmark)H-Index: 11
Last. Qihua Tan (University of Southern Denmark)H-Index: 34
view all 11 authors...
Background Multiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with risk of death. However, the inter-relatedness of the epigenetic basis of aging and mortality has not been well investigated.
7 CitationsSource
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