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Ιωάννης Π. Τρουγκάκος
130Publications
32H-index
4,689Citations
Publications 130
Newest
#1Pinelopi I. Artemaki (UoA: National and Kapodistrian University of Athens)
#2Aimilia D. Sklirou (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last.Andreas Scorilas (UoA: National and Kapodistrian University of Athens)H-Index: 51
view all 8 authors...
Abstract Objectives Clusterin (CLU) is a multifunctional intra-/extra-cellular molecular chaperone with indications of serving as a promising prognostic biomarker for colorectal cancer (CRC). Several studies have examined the potential prognostic value of the CLU protein in CRC; however, our research follows an alternative approach, focusing on the CLU mRNA expression. Design and methods Total RNA from 172 cancerous tissue specimens and 39 paired non-cancerous ones was isolated and 2 μg of this ...
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#1Tina Bagratuni (UoA: National and Kapodistrian University of Athens)H-Index: 5
#2Aimilia D. Sklirou (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last.M.A. Dimopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 106
view all 11 authors...
Despite recent biomedical improvements in treating Multiple Myeloma (MM), the disease still remains incurable. Toll like receptors (TLRs) provide a link between innate and adaptive immune responses and hence potentially correlate inflammation to cancer. Although the regulatory role of TLRs in MM has been under investigation the underlying mechanisms remain unclear. In this study we assayed the function of TLR4 in MM cell lines and in MM patients’ samples. We found that lipopolysaccharide-mediate...
1 CitationsSource
#1Zoi Evangelakou (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Maria Manola (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 4 authors...
Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions. This process is affected by both genetic and environmental (e.g., diet) factors, as well as by their constant interaction. Consistently, deregulation of nutrient sensing and signaling pathways is considered a hallmark of aging. Nutrigenomics is an emerging scientific discipline that studies changes induced by diet on the genome and thus it considers th...
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Prothymosin α (proTα) and its C-terminal decapeptide proTα(100–109) were shown to pleiotropically enhance innate and adaptive immune responses. Their activities have been broadly studied in vitro, focusing primarily on the restoration of the deficient immunoreactivity of cancer patients’ leukocytes. Previously, we showed that proTα and proTα(100–109) act as danger-associated molecular patterns (DAMPs), ligate Toll-like receptor-4, signal through TRIF- and MyD88-dependent pathways, promote the ma...
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#1Eleni N. Tsakiri (UoA: National and Kapodistrian University of Athens)H-Index: 7
#2Sentiljana Gumeni (UoA: National and Kapodistrian University of Athens)H-Index: 6
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 10 authors...
ABSTRACTThe ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics...
7 CitationsSource
#2A LainaH-Index: 3
Last.M.A. DimopoulosH-Index: 106
view all 15 authors...
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#1Aikaterini Skorda (UoA: National and Kapodistrian University of Athens)
#2Aimilia D. Sklirou (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 12 authors...
Multiple myeloma (MM) is a haematological malignancy being characterized by clonal plasma cell proliferation in the bone marrow. Targeting the proteasome with specific inhibitors (PIs) has been proven a promising therapeutic strategy and PIs have been approved for the treatment of MM and mantle‐cell lymphoma; yet, while outcome has improved, most patients inevitably relapse. As relapse refers to MM cells that survive therapy, we sought to identify the molecular responses induced in MM cells afte...
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#1Teodora Alexa-Stratulat (Grigore T. Popa University of Medicine and Pharmacy)H-Index: 2
#2Milica Pešić (University of Belgrade)H-Index: 15
Last.Chiara Riganti (UNITO: University of Turin)H-Index: 35
view all 5 authors...
Abstract Identification of multidrug (MDR) efflux transporters that belong to the ATP-Binding Cassette (ABC) superfamily, represented an important breakthrough for understanding cancer multidrug resistance (MDR) its possible overcoming. However, recent data indicate that drug resistant cells have a complex intracellular physiology that involves constant changes in energetic and oxidative-reductive metabolic pathways, as well as in the molecular circuitries connecting mitochondria, endoplasmic re...
2 CitationsSource
#1Ana Bela Sarmento-Ribeiro (UC: University of Coimbra)H-Index: 14
#2Andreas Scorilas (UoA: National and Kapodistrian University of Athens)H-Index: 51
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 5 authors...
Abstract For many decades classical anti-tumor therapies included chemotherapy, radiation and surgery; however, in the last two decades, following the identification of the genomic drivers and main hallmarks of cancer, the introduction of therapies that target specific tumor-promoting oncogenic or non-oncogenic pathways, has revolutionized cancer therapeutics. Despite the significant progress in cancer therapy, clinical oncologists are often facing the primary impediment of anticancer drug resis...
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