Emily H. Battle
University of Virginia
HepatitisCirrhosisGeneral surgeryMedicineGastroenterology
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Publications 4
OBJECTIVES: Troglitazone is a thiazolidinedione and peroxisome proliferator–activated receptor gamma (PPARγ) ligand used to treat diabetes mellitus type II. Because hyperinsulinemia may be a factor in nonalcoholic steatohepatitis (NASH), we postulated that troglitazone could have beneficial effects in this disorder. Our study was initiated before reports of idiosyncratic hepatitis induced by this agent and was completed before its recent withdrawal from the market. METHODS: We studied 10 female ...
352 CitationsSource
#1Mark T. Worthington (UVA: University of Virginia)H-Index: 10
#2Lauren Browne (UVA: University of Virginia)H-Index: 1
Last. Roger Qi Luo (UVA: University of Virginia)H-Index: 4
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Recently, mutation of the DMT1 gene has been discovered to cause ineffective intestinal iron uptake and abnormal body iron metabolism in the anemic Belgrade rat and mk mouse. DMT1 transports first-series transition metals, but only iron turns on an inward proton current. The process of iron transport was studied by transfection of human DMT1 into the COS-7 cell line. Native and epitope-tagged human DMT1 led to increased iron uptake. The human gene with the Belgrade rat mutation was found to have...
25 CitationsSource
#1Stephen H. Caldwell (UVA: University of Virginia)H-Index: 52
#2David H. Oelsner (UVA: University of Virginia)H-Index: 3
Last. Carolyn Driscoll (UVA: University of Virginia)H-Index: 11
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We characterized 70 consecutive patients with cryptogenic cirrhosis to assess major risks for liver disease. Each patient was reevaluated for past alcohol exposure, scored by the International Autoimmune Hepatitis (IAH) score and assessed for viral hepatitis risks and risks for nonalcoholic steatohepatitis (NASH). The results were compared with 50 consecutive NASH patients, 39 nonalcoholic patients age 50 and over with cirrhosis from hepatitis C, and 33 consecutive patients with cirrhosis caused...
871 CitationsSource
#1Mark T. WorthingtonH-Index: 10
#2Emily H. BattleH-Index: 3
Last. Roger Qi LuoH-Index: 4
view all 3 authors...