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Avshalom Caspi
Duke University
PsychiatryDevelopmental psychologyPsychologyCohortSocial psychology
469Publications
150H-index
80.5kCitations
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Publications 486
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#1Karen Sugden (Duke University)H-Index: 26
#2Eilis Hannon (University of Exeter)H-Index: 20
Last. Richie Poulton (University of Otago)H-Index: 90
view all 16 authors...
Summary DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide “snapshot” of >450,000 observations (probe measurements) per assay. However, the reliability of each of these measurements is not equal, and little consideration is paid to consequences for research. We correlated repeat measurements of the same DNA samples using the Illumina HumanMethylation450K a...
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#1Daniel W. Belsky (Columbia University)H-Index: 31
#2Avshalom Caspi (Duke University)H-Index: 150
Last. Renate Houts (Duke University)H-Index: 49
view all 22 authors...
Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints in trials of therapies designed to prevent disease by slowing biological aging. We report a blood-DNA-methylation measure that is sensitive to variation in pace of biological aging among individuals born the same year. We first modeled change-over-time in 18 biomarkers tracking ...
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#1Line Jee Hartmann Rasmussen (Duke University)H-Index: 5
#2Terrie E. MoffittH-Index: 161
Last. Avshalom CaspiH-Index: 150
view all 3 authors...
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#1Avshalom CaspiH-Index: 150
#1Avshalom CaspiH-Index: 8
Last. Sandhya Ramrakha (University of Otago)H-Index: 18
view all 17 authors...
Importance: Mental health professionals typically encounter patients at 1 point in patients' lives. This cross-sectional window understandably fosters focus on the current presenting diagnosis. Research programs, treatment protocols, specialist clinics, and specialist journals are oriented to presenting diagnoses, on the assumption that diagnosis informs about causes and prognosis. This study tests an alternative hypothesis: people with mental disorders experience many different kinds of disorde...
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#1Leah S. Richmond-Rakerd (UNC: University of North Carolina at Chapel Hill)H-Index: 8
#2Terrie E. MoffittH-Index: 161
Last. Joey A. Prinz (Duke University)
view all 15 authors...
BACKGROUND: A recent genome-wide association study identified molecular-genetic associations with age-at-first-birth. However, the meaning of these genetic discoveries is unclear. Drawing on evidence linking early pregnancy with disinhibitory behavior, we tested the hypothesis that genetic discoveries for age-at-first-birth predict disinhibition. METHODS: We included participants with genotype data from the two-decade-long Environmental Risk (E-Risk) Study (N = 1,999) and the four-decade-long Du...
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#1Peter T. Tanksley (UC: University of Cincinnati)H-Index: 1
#2John Barnes (UC: University of Cincinnati)H-Index: 30
Last. Terrie E. Moffitt (Duke University)H-Index: 161
view all 8 authors...
Examine the extent to which cognitive/psychological characteristics predict later polyvictimization. We employ a twin-based design that allows us to test the social neurocriminology hypothesis that environmental factors influence brain-based characteristics and influence behaviors like victimization. Using data from the Environmental Risk Longitudinal Twin Study (N = 1986), we capitalize on the natural experiment embedded in a discordant-twin design that allows for the adjustment of family envir...
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#1Christina O. Carlisi (UCL: University College London)H-Index: 11
#2Terrie E. MoffittH-Index: 161
Last. Ahmad R. Hariri (Duke University)H-Index: 74
view all 11 authors...
Summary Background Studies with behavioural and neuropsychological tests have supported the developmental taxonomy theory of antisocial behaviour, which specifies abnormal brain development as a fundamental aspect of life-course-persistent antisocial behaviour, but no study has characterised features of brain structure associated with life-course-persistent versus adolescence-limited trajectories, as defined by prospective data. We aimed to determine whether life-course-persistent antisocial beh...
1 CitationsSource
#1Daniel W. Belsky (Columbia University)H-Index: 31
#2Avshalom Caspi (Duke University)H-Index: 150
Last. William E. Kraus (Duke University)H-Index: 79
view all 17 authors...
Biological aging is the gradual and progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the rate of biological aging are needed to serve as surrogate endpoints in trials of therapies designed to prevent disease by slowing biological aging to extend healthspan. We report a blood DNA-methylation measure that is sensitive to variation in the pace of biological aging among individuals born in the same year. We first ...
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Health and social scientists have documented the hospital revolving-door problem, the concentration of crime, and long-term welfare dependence. Have these distinct fields identified the same citizens? Using administrative databases linked to 1.7 million New Zealanders, we quantified and monetized inequality in distributions of health and social problems and tested whether they aggregate within individuals. Marked inequality was observed: Gini coefficients equalled 0.96 for criminal convictions, ...
1 CitationsSource
#1Perline A. Demange (VU: VU University Amsterdam)H-Index: 1
#2Margherita Malanchini (QMUL: Queen Mary University of London)H-Index: 5
Last. Michel G. Nivard (VU: VU University Amsterdam)H-Index: 24
view all 27 authors...
Educational attainment (EA) is influenced by cognitive abilities and by other characteristics and traits. However little is known about the genetic architecture of these "non-cognitive" contributions to EA. Here, we use Genomic Structural Equation Modelling and results of prior genome-wide association studies (GWASs) of EA (N = 1,131,881) and cognitive test performance (N = 257,841) to estimate SNP associations with variation in EA that is independent of cognitive ability. We identified 157 geno...
2 CitationsSource
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