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Avshalom Caspi
King's College London
474Publications
146H-index
76.2kCitations
Publications 474
Newest
Published on Feb 15, 2019in Translational Psychiatry5.18
Karen Sugden24
Estimated H-index: 24
(Duke University),
Eilis Hannon17
Estimated H-index: 17
(University of Exeter)
+ 13 AuthorsRichie Poulton86
Estimated H-index: 86
(University of Otago)
Large-scale epigenome-wide association meta-analyses have identified multiple ‘signatures’’ of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health research. To validate the score, we use data from two birth cohort studies: The Dunedin Longitudinal Study, followed to age-38 years, and the Environmental Risk Study, followed to age-18 years. Longit...
Published on Mar 1, 2019in Biological Psychiatry11.50
Jenny van Dongen1
Estimated H-index: 1
(PHRI: Public Health Research Institute),
Nuno R. Zilhão6
Estimated H-index: 6
(PHRI: Public Health Research Institute)
+ 59 AuthorsLude Franke76
Estimated H-index: 76
(UG: University of Groningen)
Background: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult attention-deficit/hyperactivity disorder symptoms, based on peripheral blood DNA methylation (Infinium HumanMethylation450K array) in three population-based adult cohorts. Methods: An epigenome-wide association study was performed in the Netherlands Twin Register (N = 2258, me...
Published on 2019in bioRxiv
Adrienne L. Romer5
Estimated H-index: 5
(Duke University),
Maxwell L. Elliott2
Estimated H-index: 2
(Duke University)
+ 7 AuthorsTracy R. Melzer13
Estimated H-index: 13
(University of Otago)
Objective: Neuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the structural brain correlates of mental disorders mirrors already well-documented phenotypic comorbidity of psychiatric symptoms and diagnoses, which can be indexed by a general psychopathology or p factor. We hypothesized that if general psychopathology drives the convergence of structura...
Published on 2019in Schizophrenia Bulletin7.29
Antonella Trotta11
Estimated H-index: 11
('KCL': King's College London),
Louise Arseneault54
Estimated H-index: 54
('KCL': King's College London)
+ 4 AuthorsHelen L. Fisher35
Estimated H-index: 35
('KCL': King's College London)
Published on Jul 26, 2019in bioRxiv
Maxwell L. Elliott2
Estimated H-index: 2
(Duke University),
Daniel W. Belsky29
Estimated H-index: 29
+ 7 AuthorsAhmad R. Hariri71
Estimated H-index: 71
An individual's brain-age is the difference between chronological age and age predicted from machine-learning models of brain-imaging data. Brain-age has been proposed as a biomarker of age-related deterioration of the brain. Having an older brain-age has been linked to Alzheimer's, dementia and mortality. However, these findings are largely based on cross-sectional associations which can confuse age differences with cohort differences. To illuminate the validity of brain-age a biomarker of acce...
Published on 2019in Cerebral Cortex5.44
Maxwell L. Elliott2
Estimated H-index: 2
(Duke University),
Daniel W. Belsky29
Estimated H-index: 29
(Duke University)
+ 7 AuthorsDavid R. Ireland7
Estimated H-index: 7
(University of Otago)
Published on Mar 28, 2019in Developmental Psychology3.34
Jasmin Wertz8
Estimated H-index: 8
(Duke University),
Jay Belsky104
Estimated H-index: 104
(UC Davis: University of California, Davis)
+ 5 AuthorsAvshalom Caspi146
Estimated H-index: 146
Jasmin Wertz8
Estimated H-index: 8
(Duke University),
Avshalom Caspi146
Estimated H-index: 146
(Duke University)
+ 7 AuthorsTerrie E. Moffitt158
Estimated H-index: 158
(Duke University)
Abstract Objective Borderline personality disorder in adolescence remains a controversial construct. Here we addressed concerns about the prognostic significance of adolescent borderline pathology by testing whether borderline symptoms at age 12 years predict functioning during the transition to adulthood, at age 18 years, in areas critical to life-course development. Method We studied members of the Environmental Risk (E-Risk) Longitudinal Twin Study, which tracks the development of a birth coh...
Published on Jun 29, 2019in bioRxiv
Tracy C. d’Arbeloff1
Estimated H-index: 1
(Duke University),
Maxwell L. Elliott2
Estimated H-index: 2
(Duke University)
+ 9 AuthorsAvshalom Caspi146
Estimated H-index: 146
White matter hyperintensities (WMHs) proliferate as the brain ages and are associated with increased risk for cognitive decline as well as Alzheimer9s disease and related dementias. As such, WMHs have been targeted as a surrogate biomarker in intervention trials with older adults. However, it is unclear at what stage of aging WMHs begin to relate to cognition and if they may be a viable target for early prevention. In a population-representative birth cohort of 843 45-year-olds we measured WMHs ...
Published on Jun 24, 2019in bioRxiv
Maxwell L. Elliott2
Estimated H-index: 2
(Duke University),
Annchen R. Knodt10
Estimated H-index: 10
(Duke University)
+ 7 AuthorsAhmad R. Hariri71
Estimated H-index: 71
(Duke University)
Identifying brain biomarkers of disease risk and treatment response is a growing priority in neuroscience. The ability to identify meaningful biomarkers is fundamentally limited by measurement reliability; measures that do not yield reliable values are unsuitable as biomarkers to predict clinical outcomes. Measuring brain activity using task-fMRI is a major focus of biomarker development; however, the reliability of task-fMRI has not been systematically evaluated. We present converging evidence ...
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