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Sean M. Moore
University of Notre Dame
27Publications
13H-index
363Citations
Publications 29
Newest
Background Cholera causes an estimated 100,000 deaths annually worldwide, with the majority of burden reported in sub-Saharan Africa. In May 2018, the World Health Assembly committed to reducing worldwide cholera deaths by 90% by 2030. Oral cholera vaccine (OCV) plays a key role in reducing the near-term risk of cholera, although global supplies are limited. Characterizing the potential impact and cost-effectiveness of mass OCV deployment strategies is critical for setting expectations and devel...
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A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide sufficient forecast skill to be useful. We developed an open collaborative forecasting challenge to assess probabilistic forecasts for seasonal epidemics of dengue, a major global publi...
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#1Xiang Li (Imperial College London)
#2Christinah Mukandavire (Imperial College London)
Last.Tini Garske (Imperial College London)H-Index: 16
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Background The last two decades have seen substantial expansion of childhood vaccination programmes in low and middle income countries (LMICs). Here we quantify the health impact of these programmes by estimating the deaths and disability-adjusted life years (DALYs) averted by vaccination with ten antigens in 98 LMICs between 2000 and 2030. Methods Independent research groups provided model-based disease burden estimates under a range of vaccination coverage scenarios for ten pathogens: hepatiti...
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#1Sean M. Moore (ND: University of Notre Dame)H-Index: 13
#2Rachel J. Oidtman (ND: University of Notre Dame)H-Index: 2
Last.Alex Perkins (ND: University of Notre Dame)H-Index: 2
view all 7 authors...
Since the first Zika virus (ZIKV) infection was confirmed in Brazil in May 2015, several hundred thousand cases have been reported across the Americas. This figure gives an incomplete picture of the epidemic, however, given that asymptomatic infections, imperfect surveillance, and variability in reporting rates imply that the incidence of infection was likely much higher. The infection attack rate (IAR)--defined as the proportion of the population that was infected over the course of the epidemi...
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#1Andrew S. Azman (Johns Hopkins University)H-Index: 19
#2Sean M. Moore (ND: University of Notre Dame)H-Index: 13
Last.Justin Lessler (Johns Hopkins University)H-Index: 38
view all 3 authors...
1 CitationsSource
#1Elizabeth C. Lee (Johns Hopkins University)
#2Andrew S. Azman (Johns Hopkins University)H-Index: 19
Last.Justin Lessler (Johns Hopkins University)H-Index: 38
view all 6 authors...
Background: In May 2018, the World Health Assembly committed to reducing worldwide cholera deaths by 90% by 2030. Oral cholera vaccine (OCV) plays a key role in reducing the near-term risk of cholera, although global supplies are limited. Characterizing the potential impact and cost-effectiveness of mass OCV deployment strategies is critical for setting expectations and developing cholera control plans that maximize chances of success. Methods and Findings: We compared the projected impacts of v...
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#1Sean M. Moore (ND: University of Notre Dame)H-Index: 13
Last.T. Alex Perkins (ND: University of Notre Dame)H-Index: 19
view all 12 authors...
Mathematical models of transmission dynamics are routinely fitted to epidemiological time series, which must inevitably be aggregated at some spatial scale. Weekly case reports of chikungunya have been made available nationally for numerous countries in the Western Hemisphere since late 2013, and numerous models have made use of this data set for forecasting and inferential purposes. Motivated by an abundance of literature suggesting that the transmission of this mosquito-borne pathogen is local...
5 CitationsSource
#1Sara Y. Del Valle (LANL: Los Alamos National Laboratory)H-Index: 15
#2Benjamin H. McMahon (LANL: Los Alamos National Laboratory)H-Index: 19
Last.Harshini Mukundan (LANL: Los Alamos National Laboratory)H-Index: 14
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Background: Emerging pathogens such as Zika, chikungunya, Ebola, and dengue viruses are serious threats to national and global health security. Accurate forecasts of emerging epidemics and their severity are critical to minimizing subsequent mortality, morbidity, and economic loss. The recent introduction of chikungunya and Zika virus to the Americas underscores the need for better methods for disease surveillance and forecasting. Methods: To explore the suitability of current approaches to fore...
8 CitationsSource
#1Neil H. Carter (BSU: Boise State University)H-Index: 13
#2Paola BouleyH-Index: 2
Last.Stuart L. Pimm (Duke University)H-Index: 76
view all 6 authors...
3 CitationsSource
#1K. James Soda (ND: University of Notre Dame)H-Index: 2
#2Sean M. Moore (ND: University of Notre Dame)H-Index: 13
Last.Quirine A. ten Bosch (ND: University of Notre Dame)H-Index: 7
view all 11 authors...
Dengue virus (DENV) is a pathogen spread by Aedes mosquitoes that has a considerable impact on global health. Agent-based models can be used to represent explicitly represent factors that are difficult to measure empirically, by focusing on specific aspects of DENV transmission dynamics that influence spread in a particular location. We present a new agent-based model for DENV dynamics, DTK-Dengue, that can be readily applied to new locations and to a diverse set of goals. It extends the vector-...
2 CitationsSource
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