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Helen Davies
Wellcome Trust Sanger Institute
101Publications
46H-index
29.6kCitations
Publications 101
Newest
#1Arie B. Brinkman (Radboud University Nijmegen)H-Index: 29
#2Serena Nik-Zainal (University of Cambridge)H-Index: 39
Last.Hendrik G. Stunnenberg (Radboud University Nijmegen)H-Index: 89
view all 29 authors...
Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. We comprehensively show that loss of methylation in PMDs occurs in a large fraction of the genome and represents the prime source of DNA ...
2 CitationsSource
#1Marcel Smid (EUR: Erasmus University Rotterdam)H-Index: 34
#2Saskia M. Wilting (EUR: Erasmus University Rotterdam)H-Index: 20
Last.John W. M. Martens (EUR: Erasmus University Rotterdam)H-Index: 54
view all 41 authors...
Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped reads or known splice junctions. We identified 95,843 circRNAs, of which 20,441 were found recurrently. Of the circRNAs that match exon boundaries of the same gene, 668 showed a poor or even negative (R <0.2) correlation with the expression leve...
5 CitationsSource
#1Serena Nik-ZainalH-Index: 2
#2Serena Nik-ZainalH-Index: 39
Last.Michael R. StrattonH-Index: 139
view all 88 authors...
In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. '. The Article has not been corrected.
Source
#1Serena Nik-Zainal (Cambridge University Hospitals NHS Foundation Trust)H-Index: 39
#2Helen DaviesH-Index: 46
Last.Michael R. StrattonH-Index: 139
view all 88 authors...
© 2019, Springer Nature Limited. In the Methods section of this Article, ‘greater than’ should have been ‘less than’ in the sentence ‘Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. ’. The Article has not been corrected.
4 CitationsSource
#1Serena Nik-Zainal (Cambridge University Hospitals NHS Foundation Trust)H-Index: 39
#2Helen Davies (Wellcome Trust Sanger Institute)H-Index: 46
Last.Michael R. Stratton (Wellcome Trust Sanger Institute)H-Index: 139
view all 88 authors...
In the Methods section of this Article, ‘greater than’ should have been ‘less than’ in the sentence ‘Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. ’. The Article has not been corrected.
1 CitationsSource
#1Niccolo Bolli (University of Milan)H-Index: 29
#2Francesco Maura (University of Milan)H-Index: 13
Last.Nikhil C. Munshi (Harvard University)H-Index: 117
view all 24 authors...
We analyzed whole genomes of unique paired samples from smoldering multiple myeloma (SMM) patients progressing to multiple myeloma (MM). We report that the genomic landscape, including mutational profile and structural rearrangements at the smoldering stage is very similar to MM. Paired sample analysis shows two different patterns of progression: a “static progression model”, where the subclonal architecture is retained as the disease progressed to MM suggesting that progression solely reflects ...
11 CitationsSource
#1Arjen B Brinkman (Radboud University Nijmegen)H-Index: 1
#2Serena Nik-Zainal (University of Cambridge)H-Index: 39
Last.Hendrik G. Stunnenberg (Radboud University Nijmegen)H-Index: 89
view all 29 authors...
Global loss of DNA methylation and CpG island (CGI) hypermethylation are regarded as key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which can extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. Using whole genome bisulfite sequencing (WGBS) of breast cancers, we comprehensively show that loss of methylation in PMD...
1 CitationsSource
#1Frederick Arce Vargas (UCL: University College London)H-Index: 6
#2Andrew J.S. Furness (UCL: University College London)H-Index: 12
Last.Sergio A. Quezada (UCL: University College London)H-Index: 22
view all 255 authors...
Summary With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo , increasing the CD8 + to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to ipilimumab was associated with the CD16a-V158F...
88 CitationsSource
#1Francesco Maura (University of Milan)H-Index: 13
#2Mia Petljak (Wellcome Trust Sanger Institute)H-Index: 9
Last.Niccolo Bolli (University of Milan)H-Index: 29
view all 25 authors...
Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines
11 CitationsSource
#1Christopher AbboshH-Index: 7
Last.Charles SwantonH-Index: 66
view all 104 authors...
Nature 545, 446–451 (2017); doi:10.1038/nature22364 For 6 of the 96 patients included in this Article (patients CRUK0014, CRUK0030, CRUK0048, CRUK0059, CRUK0096 and CRUK0097) incorrect tumour volumetric data and positron emission tomography (PET) tumour background ratio (TBR) data were analysed. This error occurred because of the incorrect assignment of patient identifiers during the anonymization mandated by the independent review board of pre-operative computed tomography (CT) scans belonging ...
4 CitationsSource
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